JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 74: 1137-1148, 1995;
0022-3077/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (67)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cardozo, D. L.
Right arrow Articles by Bean, B. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cardozo, D. L.
Right arrow Articles by Bean, B. P.

Journal of Neurophysiology, Vol 74, Issue 3 1137-1148, Copyright © 1995 by APS

ARTICLES

Voltage-dependent calcium channels in rat midbrain dopamine neurons: modulation by dopamine and GABAB receptors

D. L. Cardozo and B. P. Bean
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

1. Voltage-dependent calcium channels were studied with whole cell voltage-clamp recordings from neurons enzymatically dispersed from the ventral mesencephalon of rat brains (postnatal days 3-10) and identified as dopamine neurons by 5,7-dihydroxytryptamine autofluorescence. 2. Dopamine neurons had large high-threshold calcium currents activated by depolarizations positive to -50 mV. Different components of calcium channel current were not readily distinguishable by voltage dependence or kinetics, but pharmacological experiments showed the existence of different channel types. The overall current had significant components blocked by nimodipine (28%), by omega-conotoxin GVIA (22%), and by omega-agatoxin-IVA (omega-Aga-IVA) (37%), and there was a significant amount of current (16%) remaining in saturating concentrations of all three blockers. 3. High-threshold calcium current was reversibly reduced by the gamma-aminobutyric acid-B (GABAB) receptor agonist baclofen and by dopamine and the D2 receptor agonist quinpirole. Inhibition by GABAB or dopamine agonists developed and reversed within seconds. 4. Quinpirole reduced both omega-conotoxin-sensitive and omega-Aga-IVA-sensitive components of calcium current. 5. With physiological ionic conditions, inward calcium currents were outweighed by outward currents, in part through calcium-activated potassium channels activated by omega-conotoxin-sensitive and omega-Aga-IVA-sensitive calcium entry.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
Y. Hayashida, C. V. Rodriguez, G. Ogata, G. J. Partida, H. Oi, T. W. Stradleigh, S. C. Lee, A. F. Colado, and A. T. Ishida
Inhibition of Adult Rat Retinal Ganglion Cells by D1-Type Dopamine Receptor Activation
J. Neurosci., November 25, 2009; 29(47): 15001 - 15016.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. C. Foehring, X. F. Zhang, J.C.F. Lee, and J. C. Callaway
Endogenous Calcium Buffering Capacity of Substantia Nigral Dopamine Neurons
J Neurophysiol, October 1, 2009; 102(4): 2326 - 2333.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. D. Kline, G. Hendricks, G. Hermann, R. C. Rogers, and D. L. Kunze
Dopamine Inhibits N-Type Channels in Visceral Afferents to Reduce Synaptic Transmitter Release Under Normoxic and Chronic Intermittent Hypoxic Conditions
J Neurophysiol, May 1, 2009; 101(5): 2270 - 2278.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. N. Schultz, S. A. von Esenwein, M. Hu, A. L. Bennett, R. T. Kennedy, S. Musatov, C. D. Toran-Allerand, M. G. Kaplitt, L. J. Young, and J. B. Becker
Viral Vector-Mediated Overexpression of Estrogen Receptor-{alpha} in Striatum Enhances the Estradiol-Induced Motor Activity in Female Rats and Estradiol-Modulated GABA Release
J. Neurosci., February 11, 2009; 29(6): 1897 - 1903.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. C. Canavier, S. A. Oprisan, J. C. Callaway, H. Ji, and P. D. Shepard
Computational Model Predicts a Role for ERG Current in Repolarizing Plateau Potentials in Dopamine Neurons: Implications for Modulation of Neuronal Activity
J Neurophysiol, November 1, 2007; 98(5): 3006 - 3022.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Liu, J. Dore, and X. Chen
Calcium Influx through L-type Channels Generates Protein Kinase M to Induce Burst Firing of Dopamine Cells in the Rat Ventral Tegmental Area
J. Biol. Chem., March 23, 2007; 282(12): 8594 - 8603.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Puopolo, E. Raviola, and B. P. Bean
Roles of Subthreshold Calcium Current and Sodium Current in Spontaneous Firing of Mouse Midbrain Dopamine Neurons
J. Neurosci., January 17, 2007; 27(3): 645 - 656.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. C. Canavier and R. S. Landry
An Increase in AMPA and a Decrease in SK Conductance Increase Burst Firing by Different Mechanisms in a Model of a Dopamine Neuron In Vivo
J Neurophysiol, November 1, 2006; 96(5): 2549 - 2563.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Hahn, P. H. M. Kullmann, J. P. Horn, and E. S. Levitan
D2 autoreceptors chronically enhance dopamine neuron pacemaker activity.
J. Neurosci., May 10, 2006; 26(19): 5240 - 5247.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y.-W. Cheng, M.-C. Ku, C.-M. Ho, C.-Y. Chai, and C.-K. Su
GABAB-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats
J Appl Physiol, November 1, 2005; 99(5): 1658 - 1667.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Cui, T. Okamoto, and H. Morikawa
Spontaneous Opening of T-Type Ca2+ Channels Contributes to the Irregular Firing of Dopamine Neurons in Neonatal Rats
J. Neurosci., December 8, 2004; 24(49): 11079 - 11087.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. Bettler, K. Kaupmann, J. Mosbacher, and M. Gassmann
Molecular Structure and Physiological Functions of GABAB Receptors
Physiol Rev, July 1, 2004; 84(3): 835 - 867.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. Durante, C. G. Cardenas, J. A. Whittaker, S. T. Kitai, and R. S. Scroggs
Low-Threshold L-type Calcium Channels in Rat Dopamine Neurons
J Neurophysiol, March 1, 2004; 91(3): 1450 - 1454.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Hahn, T. E. Tse, and E. S. Levitan
Long-Term K+ Channel-Mediated Dampening of Dopamine Neuron Excitability by the Antipsychotic Drug Haloperidol
J. Neurosci., November 26, 2003; 23(34): 10859 - 10866.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
Y. M. Choi, S. H. Kim, D. Y. Uhm, and M. K. Park
Glutamate-mediated [Ca2+]c dynamics in spontaneously firing dopamine neurons of the rat substantia nigra pars compacta
J. Cell Sci., July 1, 2003; 116(13): 2665 - 2675.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. D. Traub, E. H. Buhl, T. Gloveli, and M. A. Whittington
Fast Rhythmic Bursting Can Be Induced in Layer 2/3 Cortical Neurons by Enhancing Persistent Na+ Conductance or by Blocking BK Channels
J Neurophysiol, February 1, 2003; 89(2): 909 - 921.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Schmitz, C. Schmauss, and D. Sulzer
Altered Dopamine Release and Uptake Kinetics in Mice Lacking D2 Receptors
J. Neurosci., September 15, 2002; 22(18): 8002 - 8009.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Wolfart and J. Roeper
Selective Coupling of T-Type Calcium Channels to SK Potassium Channels Prevents Intrinsic Bursting in Dopaminergic Midbrain Neurons
J. Neurosci., May 1, 2002; 22(9): 3404 - 3413.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. O. Komendantov and C. C. Canavier
Electrical Coupling Between Model Midbrain Dopamine Neurons: Effects on Firing Pattern and Synchrony
J Neurophysiol, March 1, 2002; 87(3): 1526 - 1541.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Neuhoff, A. Neu, B. Liss, and J. Roeper
Ih Channels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain
J. Neurosci., February 15, 2002; 22(4): 1290 - 1302.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. Congar, A. Bergevin, and L.-E. Trudeau
D2 Receptors Inhibit the Secretory Process Downstream From Calcium Influx in Dopaminergic Neurons: Implication of K+ Channels
J Neurophysiol, February 1, 2002; 87(2): 1046 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Schmitz, C. J. Lee, C. Schmauss, F. Gonon, and D. Sulzer
Amphetamine Distorts Stimulation-Dependent Dopamine Overflow: Effects on D2 Autoreceptors, Transporters, and Synaptic Vesicle Stores
J. Neurosci., August 15, 2001; 21(16): 5916 - 5924.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W.-J. Song, Y. Baba, T. Otsuka, and F. Murakami
Characterization of Ca2+ Channels in Rat Subthalamic Nucleus Neurons
J Neurophysiol, November 1, 2000; 84(5): 2630 - 2637.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Jones, J. L. Kornblum, and J. A. Kauer
Amphetamine Blocks Long-Term Synaptic Depression in the Ventral Tegmental Area
J. Neurosci., August 1, 2000; 20(15): 5575 - 5580.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. J. Thomas, R. C. Malenka, and A. Bonci
Modulation of Long-Term Depression by Dopamine in the Mesolimbic System
J. Neurosci., August 1, 2000; 20(15): 5581 - 5586.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Lotharius, L. L. Dugan, and K. L. O'Malley
Distinct Mechanisms Underlie Neurotoxin-Mediated Cell Death in Cultured Dopaminergic Neurons
J. Neurosci., February 15, 1999; 19(4): 1284 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Bonci, P. Grillner, N. B. Mercuri, and G. Bernardi
L-Type Calcium Channels Mediate a Slow Excitatory Synaptic Transmission in Rat Midbrain Dopaminergic Neurons
J. Neurosci., September 1, 1998; 18(17): 6693 - 6703.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Feigenspan, S. Gustincich, B. P. Bean, and E. Raviola
Spontaneous Activity of Solitary Dopaminergic Cells of the Retina
J. Neurosci., September 1, 1998; 18(17): 6776 - 6789.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Formenti, M. Martina, A. Plebani, and M. Mancia
Multiple modulatory effects of dopamine on calcium channel kinetics in adult rat sensory neurons
J. Physiol., June 1, 1998; 509(2): 395 - 409.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y.-W. Li, P. G. Guyenet, and D. A. Bayliss
Voltage-Dependent Calcium Currents in Bulbospinal Neurons of Neonatal Rat Rostral Ventrolateral Medulla: Modulation by alpha 2-Adrenergic Receptors
J Neurophysiol, February 1, 1998; 79(2): 583 - 594.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. M. Raman and B. P. Bean
Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons
J. Neurosci., June 15, 1997; 17(12): 4517 - 4526.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online