Journal of Neurophysiology, Vol 74, Issue 4 1800-1805, Copyright © 1995 by APS

ARTICLES

Neurons in the globus pallidus do not show correlated activity in the normal monkey, but phase-locked oscillations appear in the MPTP model of parkinsonism

A. Nini, A. Feingold, H. Slovin and H. Bergman
Department of Physiology, Hebrew University, Hadassah Medical School, Jerusalem, Israel.

1. To test the mode of functional connectivity in the basal ganglia circuitry, we studied the activity of simultaneously recorded neurons in the globus pallidus (GP) of a behaving rhesus monkey. The cross-correlograms of pairs of neurons in the GP were compared with those of neurons in the thalamus and frontal cortex and to the cross-correlograms of pallidal pairs after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. 2. In contrast with cortical and thalamic neuronal activity, almost all pairs (n = 76/81 pairs; 93.8%, 1,629/1,651 histograms; 98.7%) of GP neurons in the normal monkey were not driven by a common input. 3. The monkey was systemically treated with MPTP until the appearance of parkinsonian signs and an intermittent 7- to 11-Hz action/postural tremor. After the MPTP treatment, many pallidal neurons (49/140; 35%) became oscillatory, and 19% (n = 31/162) of pallidal pairs had oscillatory cross-correlograms. 4. These results support the model of parallel processing in the basal ganglia of normal monkeys and suggest a breakdown of the independent activity in the parkinsonian state.

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				D. N. Ruskin, D. A. Bergstrom, and J. R. Walters Multisecond Oscillations in Firing Rate in the Globus Pallidus: Synergistic Modulation by D1 and D2 Dopamine Receptors J. Pharmacol. Exp. Ther., September 1, 1999; 290(3): 1493 - 1501. [Abstract] [Full Text]

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				D. N. Ruskin, D. A. Bergstrom, Y. Kaneoke, B. N. Patel, M. J. Twery, and J. R. Walters Multisecond Oscillations in Firing Rate in the Basal Ganglia: Robust Modulation by Dopamine Receptor Activation and Anesthesia J Neurophysiol, May 1, 1999; 81(5): 2046 - 2055. [Abstract] [Full Text] [PDF]

				J. M. Hurtado, C. M. Gray, L. B. Tamas, and K. A. Sigvardt Dynamics of tremor-related oscillations in the human globus pallidus: A single case study PNAS, February 16, 1999; 96(4): 1674 - 1679. [Abstract] [Full Text] [PDF]

				C. Beurrier, P. Congar, B. Bioulac, and C. Hammond Subthalamic Nucleus Neurons Switch from Single-Spike Activity to Burst-Firing Mode J. Neurosci., January 15, 1999; 19(2): 599 - 609. [Abstract] [Full Text] [PDF]

				M. D. Bevan, P. A. C. Booth, S. A. Eaton, and J. P. Bolam Selective Innervation of Neostriatal Interneurons by a Subclass of Neuron in the Globus Pallidus of the Rat J. Neurosci., November 15, 1998; 18(22): 9438 - 9452. [Abstract] [Full Text] [PDF]