JN AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 74: 1806-1809, 1995;
0022-3077/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huang, W.
Right arrow Articles by Chesler, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huang, W.
Right arrow Articles by Chesler, M.

Journal of Neurophysiology, Vol 74, Issue 4 1806-1809, Copyright © 1995 by APS

ARTICLES

Addition of carbonic anhydrase augments extracellular pH buffering in rat cerebral cortex

W. Huang, S. E. Smith and M. Chesler
Department of Physiology, New York University Medical Center, New York 10016, USA.

1. The ability of the extracellular space to buffer rapid alkaline shifts was studied in rat cortex in vitro and in vivo. Alkaline shifts were generated by iontophoresis of OH- or were evoked by pressure ejection of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). 2. In cortical slices, alkaline shifts induced by OH- were enhanced by the carbonic anhydrase (CA) inhibitor benzolamide (83 +/- 16%, mean +/- SE), and were decreased by superfusion of 10 mg/l CA (-59 +/- 4%). CA had no effect at 1 mg/l, and no additional effect at 100 mg/l. 3. In slices, and in vivo, alkaline shifts induced by AMPA were similarly enhanced by benzolamide and decreased by superfusion of CA. 4. These data indicate that extracellular CA activity is less than that required for maximum buffering. This suggests that equilibrium between CO2 and bicarbonate may not be attained during rapid extracellular pH shifts.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Makani and M. Chesler
Endogenous Alkaline Transients Boost Postsynaptic NMDA Receptor Responses in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., July 11, 2007; 27(28): 7438 - 7446.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Fedirko, M. Avshalumov, M. E. Rice, and M. Chesler
Regulation of Postsynaptic Ca2+ Influx in Hippocampal CA1 Pyramidal Neurons via Extracellular Carbonic Anhydrase
J. Neurosci., January 31, 2007; 27(5): 1167 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C.-K. Tong, K. Chen, and M. Chesler
Kinetics of Activity-Evoked pH Transients and Extracellular pH Buffering in Rat Hippocampal Slices
J Neurophysiol, June 1, 2006; 95(6): 3686 - 3697.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. CHESLER
Regulation and Modulation of pH in the Brain
Physiol Rev, October 1, 2003; 83(4): 1183 - 1221.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C.-K. Tong, L. P. Brion, C. Suarez, and M. Chesler
Interstitial Carbonic Anhydrase (CA) Activity in Brain Is Attributable to Membrane-Bound CA Type IV
J. Neurosci., November 15, 2000; 20(22): 8247 - 8253.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. K. Tong and M. Chesler
Modulation of Spreading Depression by Changes in Extracellular pH
J Neurophysiol, November 1, 2000; 84(5): 2449 - 2457.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C.-H. Leem and R. D Vaughan-Jones
Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte
J. Physiol., June 1, 1998; 509(2): 471 - 485.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online