| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 74, Issue 5 1920-1928, Copyright © 1995 by APS
ARTICLES |
H. Qian and J. E. Dowling
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
1. gamma-Aminobutyric acid (GABA) responses from solitory hybrid bass retinal bipolar cells were studied with the use of conventional and perforated whole cell patch-clamp recording. 2. GABA elicited a chloride current in bipolar cells that had both transient and sustained components. The transient component was sensitive to bicuculline and resembled GABAA-mediated currents, whereas the more sustained component was resistant to bicuculline and resembled the responses mediated by GABAC receptors. 3. The bicuculline-resistant GABA responses recorded from the bipolar cells could not be modulated by either diazepam or pentobarbital sodium, and they were unaffected by phaclofen and 2-hydroxysaclofen, GABAB receptor antagonists. On the other hand, the bicuculline-resistant GABA responses could be blocked substantially by imidazole-4-acetic acid (I4AA), a competitive antagonist of GABAC receptors. 4. Noise analysis of the GABA-elicited currents suggested a different single channel conductance for GABAA (10.1 pS) and GABAC receptors (3.6 pS). 5. Zinc, a putative modulator of synaptic transmission, strongly inhibited the GABAC responses on bipolar cells, whereas the GABAA responses were not significantly affected by zinc. 6. The proportion of the GABAC to GABAA responses varied widely between bipolar cells. Local application of GABA onto dendrites or axon terminals showed that both types of GABA receptors are present on both regions of the cell. 7. The distinct properties of these two GABA receptor types suggest that they play different roles in retinal function.
This article has been cited by other articles:
|
|
 |
|
  M. J. Palmer Functional segregation of synaptic GABAA and GABAC receptors in goldfish bipolar cell terminals J. Physiol., November 15, 2006; 577(1): 45 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Ramsey, H. Ripps, and H. Qian An Electrophysiological Study of Retinal Function in the Diabetic Female Rat Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 5116 - 5124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Eggers and P. D. Lukasiewicz Receptor and transmitter release properties set the time course of retinal inhibition. J. Neurosci., September 13, 2006; 26(37): 9413 - 9425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Qian, Y. Pan, Y. Zhu, and P. Khalili Picrotoxin Accelerates Relaxation of GABAC Receptors Mol. Pharmacol., February 1, 2005; 67(2): 470 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chang, D. F. Covey, and D. S. Weiss Correlation of the Apparent Affinities and Efficacies of gamma -Aminobutyric AcidC Receptor Agonists Mol. Pharmacol., April 13, 2001; 58(6): 1375 - 1380. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. H. Grahn, P. G. Paterson, K. T. Gottschall-Pass, and Z. Zhang Zinc and the Eye J. Am. Coll. Nutr., April 1, 2001; 20(2): 106 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-L. Du and X.-L. Yang Subcellular Localization and Complements of GABAA and GABAC Receptors on Bullfrog Retinal Bipolar Cells J Neurophysiol, August 1, 2000; 84(2): 666 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Shields, M. N. Tran, R. O. L. Wong, and P. D. Lukasiewicz Distinct Ionotropic GABA Receptors Mediate Presynaptic and Postsynaptic Inhibition in Retinal Bipolar Cells J. Neurosci., April 1, 2000; 20(7): 2673 - 2682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Akasu, Y. Munakata, M. Tsurusaki, and H. Hasuo Role of GABAA and GABAC Receptors in the Biphasic GABA Responses in Neurons of the Rat Major Pelvic Ganglia J Neurophysiol, September 1, 1999; 82(3): 1489 - 1496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release Physiol Rev, July 1, 1999; 79(3): 1019 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hartveit Reciprocal Synaptic Interactions Between Rod Bipolar Cells and Amacrine Cells in the Rat Retina J Neurophysiol, June 1, 1999; 81(6): 2923 - 2936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. B. Liu, G.-L. Ye, X.-S. Liu, J. F. Pasternak, and B. L. Trommer GABAA Currents in Immature Dentate Gyrus Granule Cells J Neurophysiol, November 1, 1998; 80(5): 2255 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gao and S. M. Wu Characterization of Spontaneous Inhibitory Synaptic Currents in Salamander Retinal Ganglion Cells J Neurophysiol, October 1, 1998; 80(4): 1752 - 1764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Akopian, R. Gabriel, and P. Witkovsky Calcium Released From Intracellular Stores Inhibits GABAA-Mediated Currents in Ganglion Cells of the Turtle Retina J Neurophysiol, September 1, 1998; 80(3): 1105 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Lukasiewicz and C. R. Shields Different Combinations of GABAA and GABAC Receptors Confer Distinct Temporal Properties to Retinal Synaptic Responses J Neurophysiol, June 1, 1998; 79(6): 3157 - 3167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Dong and F. S. Werblin Temporal Contrast Enhancement via GABAC Feedback at Bipolar Terminals in the Tiger Salamander Retina J Neurophysiol, April 1, 1998; 79(4): 2171 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Martinez-Torres, A. E. Vazquez, M. M. Panicker, and R. Miledi Cloning and functional expression of alternative spliced variants of the rho 1 gamma -aminobutyrate receptor PNAS, March 31, 1998; 95(7): 4019 - 4022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Euler and H. Wassle Different Contributions of GABAA and GABAC Receptors to Rod and Cone Bipolar Cells in a Rat Retinal Slice Preparation J Neurophysiol, March 1, 1998; 79(3): 1384 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Qian, L. Li, R. L. Chappell, and H. Ripps GABA Receptors of Bipolar Cells From the Skate Retina: Actions of Zinc on GABA-Mediated Membrane Currents J Neurophysiol, November 1, 1997; 78(5): 2402 - 2412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Hackam, T.-L. Wang, W. B. Guggino, and G. R. Cutting The N-terminal Domain of Human GABA Receptor rho 1 Subunits Contains Signals for Homooligomeric and Heterooligomeric Interaction J. Biol. Chem., May 23, 1997; 272(21): 13750 - 13757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Enz, J. H. Brandstatter, H. Wassle, and J. Bormann Immunocytochemical Localization of the GABAC Receptor rho Subunits in the Mammalian Retina J. Neurosci., July 15, 1996; 16(14): 4479 - 4490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Martinez-Torres, A. Demuro, and R. Miledi GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization PNAS, March 28, 2000; 97(7): 3562 - 3566. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
