JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 75: 1843-1857, 1996;
0022-3077/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meredith, M. A.
Right arrow Articles by Stein, B. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meredith, M. A.
Right arrow Articles by Stein, B. E.

Journal of Neurophysiology, Vol 75, Issue 5 1843-1857, Copyright © 1996 by APS

ARTICLES

Spatial determinants of multisensory integration in cat superior colliculus neurons

M. A. Meredith and B. E. Stein
Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0709, USA.

1. Although a representation of multisensory space is contained in the superior colliculus, little is known about the spatial requirements of multisensory stimuli that influence the activity of neurons here. Critical to this problem is an assessment of the registry of the different receptive fields within individual multisensory neurons. The present study was initiated to determine how closely the receptive fields of individual multisensory neurons are aligned, the physiological role of that alignment, and the possible functional consequences of inducing receptive-field misalignment. 2. Individual multisensory neurons in the superior colliculus of anesthetized, paralyzed cats were studied with the use of standard extracellular recording techniques. The receptive fields of multisensory neurons were large, as reported previously, but exhibited a surprisingly high degree of spatial coincidence. The average proportion of receptive-field overlap was 86% for the population of visual-auditory neurons sampled. 3. Because of this high degree of intersensory receptive-field correspondence, combined-modality stimuli that were coincident in space tended to fall within the excitatory regions of the receptive fields involved. The result was a significantly enhanced neuronal response in 88% of the multisensory neurons studied. If stimuli were spatially disparate, so that one fell outside its receptive field, either a decreased response occurred (56%), or no intersensory effect was apparent (44%). 4. The normal alignment of the different receptive fields of a multisensory neuron could be disrupted by passively displacing the eyes, pinnae, or limbs/body. In no case was a shift in location or size observed in a neuron's other receptive field(s) to compensate for this displacement. The physiological result of receptive-field misalignment was predictable and based on the location of the stimuli relative to the new positions of their respective receptive fields. Now, for example, one component of a spatially coincident pair of stimuli might fall outside its receptive field and inhibit the other's effects. 5. These data underscore the dependence of multisensory integrative responses on the relationship of the different stimuli to their corresponding receptive fields rather than to the spatial relationship of the stimuli to one another. Apparently, the alignment of different receptive fields for individual multisensory neurons ensures that responses to combinations of stimuli derived from the same event are integrated to increase the salience of that event. Therefore the maintenance of receptive-field alignment is critical for the appropriate integration of converging sensory signals and, ultimately, elicitation of adaptive behaviors.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
B. N. Carriere, D. W. Royal, and M. T. Wallace
Spatial Heterogeneity of Cortical Receptive Fields and Its Impact on Multisensory Interactions
J Neurophysiol, May 1, 2008; 99(5): 2357 - 2368.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. C. Alvarado, T. R. Stanford, J. W. Vaughan, and B. E. Stein
Cortex Mediates Multisensory But Not Unisensory Integration in Superior Colliculus
J. Neurosci., November 21, 2007; 27(47): 12775 - 12786.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. N. Carriere, D. W. Royal, T. J. Perrault, S. P. Morrison, J. W. Vaughan, B. E. Stein, and M. T. Wallace
Visual Deprivation Alters the Development of Cortical Multisensory Integration
J Neurophysiol, November 1, 2007; 98(5): 2858 - 2867.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
H.-J. Lee, E. Truy, G. Mamou, D. Sappey-Marinier, and A.-L. Giraud
Visual speech circuits in profound acquired deafness: a possible role for latent multimodal connectivity
Brain, November 1, 2007; 130(11): 2929 - 2941.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Hein, O. Doehrmann, N. G. Muller, J. Kaiser, L. Muckli, and M. J. Naumer
Object Familiarity and Semantic Congruency Modulate Responses in Cortical Audiovisual Integration Areas
J. Neurosci., July 25, 2007; 27(30): 7881 - 7887.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Avillac, S. Ben Hamed, and J.-R. Duhamel
Multisensory Integration in the Ventral Intraparietal Area of the Macaque Monkey
J. Neurosci., February 21, 2007; 27(8): 1922 - 1932.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. R. Fetsch, S. Wang, Y. Gu, G. C. DeAngelis, and D. E. Angelaki
Spatial Reference Frames of Visual, Vestibular, and Multimodal Heading Signals in the Dorsal Subdivision of the Medial Superior Temporal Area
J. Neurosci., January 17, 2007; 27(3): 700 - 712.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. T. Wallace and B. E. Stein
Early Experience Determines How the Senses Will Interact
J Neurophysiol, January 1, 2007; 97(1): 921 - 926.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. Jiang, H. Jiang, and B. E. Stein
Neonatal Cortical Ablation Disrupts Multisensory Development in Superior Colliculus
J Neurophysiol, March 1, 2006; 95(3): 1380 - 1396.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. H. Bell, M. A. Meredith, A. J. Van Opstal, and D. P. Munoz
Crossmodal Integration in the Primate Superior Colliculus Underlying the Preparation and Initiation of Saccadic Eye Movements
J Neurophysiol, June 1, 2005; 93(6): 3659 - 3673.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. J. Perrault Jr., J. W. Vaughan, B. E. Stein, and M. T. Wallace
Superior Colliculus Neurons Use Distinct Operational Modes in the Integration of Multisensory Stimuli
J Neurophysiol, May 1, 2005; 93(5): 2575 - 2586.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
N. E. Barraclough, D. Xiao, C. I. Baker, M. W. Oram, and D. I. Perrett
Integration of Visual and Auditory Information by Superior Temporal Sulcus Neurons Responsive to the Sight of Actions
J. Cogn. Neurosci., March 1, 2005; 17(3): 377 - 391.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. M. Small, J. Voss, Y. E. Mak, K. B. Simmons, T. Parrish, and D. Gitelman
Experience-Dependent Neural Integration of Taste and Smell in the Human Brain
J Neurophysiol, September 1, 2004; 92(3): 1892 - 1903.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
L. R. Dehner, L. P. Keniston, H. R. Clemo, and M. A. Meredith
Cross-modal Circuitry Between Auditory and Somatosensory Areas of the Cat Anterior Ectosylvian Sulcal Cortex: A 'New' Inhibitory Form of Multisensory Convergence
Cereb Cortex, April 1, 2004; 14(4): 387 - 403.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. J. Perrault Jr., J. W. Vaughan, B. E. Stein, and M. T. Wallace
Neuron-Specific Response Characteristics Predict the Magnitude of Multisensory Integration
J Neurophysiol, December 1, 2003; 90(6): 4022 - 4026.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. Jiang and B. E. Stein
Cortex Controls Multisensory Depression in Superior Colliculus
J Neurophysiol, October 1, 2003; 90(4): 2123 - 2135.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. J. Anastasio and P. E. Patton
A Two-Stage Unsupervised Learning Algorithm Reproduces Multisensory Enhancement in a Neural Network Model of the Corticotectal System
J. Neurosci., July 30, 2003; 23(17): 6713 - 6727.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. P. Doubell, I. Skaliora, J. Baron, and A. J. King
Functional Connectivity between the Superficial and Deeper Layers of the Superior Colliculus: An Anatomical Substrate for Sensorimotor Integration
J. Neurosci., July 23, 2003; 23(16): 6596 - 6607.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
P. E. Patton and T. J. Anastasio
Modeling Cross-Modal Enhancement and Modality-Specific Suppression in Multisensory Neurons
Neural Comput., April 1, 2003; 15(4): 783 - 810.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
P. R. Manger, I. Masiello, and G. M. Innocenti
Areal Organization of the Posterior Parietal Cortex of the Ferret (Mustela putorius)
Cereb Cortex, December 1, 2002; 12(12): 1280 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
W. Jiang, H. Jiang, and B. E. Stein
Two Corticotectal Areas Facilitate Multisensory Orientation Behavior
J. Cogn. Neurosci., November 1, 2002; 14(8): 1240 - 1255.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. C. Populin and T. C. T. Yin
Bimodal Interactions in the Superior Colliculus of the Behaving Cat
J. Neurosci., April 1, 2002; 22(7): 2826 - 2834.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
G. A. Calvert
Crossmodal Processing in the Human Brain: Insights from Functional Neuroimaging Studies
Cereb Cortex, December 1, 2001; 11(12): 1110 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. T. Wallace and B. E. Stein
Sensory and Multisensory Responses in the Newborn Monkey Superior Colliculus
J. Neurosci., November 15, 2001; 21(22): 8886 - 8894.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Zangenehpour and A. Chaudhuri
Neural Activity Profiles of the Neocortex and Superior Colliculus after Bimodal Sensory Stimulation
Cereb Cortex, October 1, 2001; 11(10): 924 - 935.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. Jiang, M. T. Wallace, H. Jiang, J. W. Vaughan, and B. E. Stein
Two Cortical Areas Mediate Multisensory Integration in Superior Colliculus Neurons
J Neurophysiol, February 1, 2001; 85(2): 506 - 522.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. T. Wallace and B. E. Stein
Onset of Cross-Modal Synthesis in the Neonatal Superior Colliculus is Gated by the Development of Cortical Influences
J Neurophysiol, June 1, 2000; 83(6): 3578 - 3582.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
T. J. Anastasio, P. E. Patton, and K. Belkacem-Boussaid
Using Bayes' Rule to Model Multisensory Enhancement in the Superior Colliculus
Neural Comput., May 1, 2000; 12(5): 1165 - 1187.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
D. C. Kadunce, J. W. Vaughan, M. T. Wallace, G. Benedek, and B. E. Stein
Mechanisms of Within- and Cross-Modality Suppression in the Superior Colliculus
J Neurophysiol, December 1, 1997; 78(6): 2834 - 2847.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. T. Wallace and B. E. Stein
Development of Multisensory Neurons and Multisensory Integration in Cat Superior Colliculus
J. Neurosci., April 1, 1997; 17(7): 2429 - 2444.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. D. Corneil and D. P. Munoz
The Influence of Auditory and Visual Distractors on Human Orienting Gaze Shifts
J. Neurosci., December 15, 1996; 16(24): 8193 - 8207.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online