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J Neurophysiol 76: 808-815, 1996;
0022-3077/96 $5.00
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Journal of Neurophysiology, Vol 76, Issue 2 808-815, Copyright © 1996 by APS

ARTICLES

Metabotropic glutamate receptors potentiate responses to NMDA and AMPA from layer V cells in rat visual cortex

X. F. Wang and N. W. Daw
Department of Ophthalmology and Visual Science, Yale University Medical School, New Haven, Connecticut 06520-8061, USA.

1. With the use of whole cell recordings of layer V cells from slices of rat visual cortex, we demonstrate a potentiation of the response to N-methyl-D-aspartate (NMDA) by the metabotropic glutamate agonist (1S,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid. This potentiation occurs within a few seconds and lasts a few minutes. 2. The potentiation is seen with tetrodotoxin in the perfusion solution, but is abolished by guanosine 5'-O-(2-thiodiphosphate) in the pipette solution, showing that it is a postsynaptic phenomenon. The potentiation is also abolished by alpha-methyl-4-carboxyphenylglycine in the bath solution, confirming that it is due to metabotropic glutamate receptors. 3. In 29 of 31 cases tested, the response to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid was also potentiated, and the potentiation remained in the presence of the NMDA antagonist D-2-amino-5-phosphonovalerate.


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