JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 76: 2125-2130, 1996;
0022-3077/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fleidervish, I. A.
Right arrow Articles by Gutnick, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fleidervish, I. A.
Right arrow Articles by Gutnick, M. J.

Journal of Neurophysiology, Vol 76, Issue 3 2125-2130, Copyright © 1996 by APS

ARTICLES

Kinetics of slow inactivation of persistent sodium current in layer V neurons of mouse neocortical slices

I. A. Fleidervish and M. J. Gutnick
Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel.

1. In whole cell recordings from layer V neurons in slices of mouse somatosensory neocortex, tetrodotoxin (TTX)-sensitive persistent Na+ current (INaP) was studied by blocking K+ currents with intracellular Cs+ and Ca2+ currents with extracellular Cd2+. During slow voltage ramps, INaP began to activate at around -60 mV, and attained a peak at around -25 mV. The peak amplitude of INaP varied widely from cell to cell (range 60-3,160 pA; median 308 pA, n = 77). At potentials more positive than -35 mV, INaP in all cells was superimposed on a large, TTX-resistant outward current. 2. In hybrid clamp experiments, INaP was significantly reduced by a preceding high-frequency train of spikes. 3. INaP underwent pronounced slow inactivation, which was revealed by systematically varying the ramp speed between 233 and 2.33 mV/s, or varying the duration of a depolarizing prepulse between 0.1 and 10 s. 4. Onset of slow inactivation at +20 mV was monoexponential with tau = 2.06 s (n = 17 cells). Recovery from slow inactivation was voltage dependent. It followed a monoexponential time course with tau = 2.31 s (n = 6) at -70 mV and tau = 1.10 s (n = 4) at -90 mV. These values are not significantly different than values previously reported for slow inactivation of fast-inactivating INa. 5. Slow inactivation of neocortical INaP will influence all neuronal functions in which this current plays a role, including spike threshold determination, synaptic integration, and active propagation in dendrites. The kinetics of slow inactivation suggest that it may be a factor not only during extremely intense spiking, but also during periods of "spontaneous" activity.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
L. Castelli, G. Biella, M. Toselli, and J. Magistretti
Resurgent Na+ current in pyramidal neurones of rat perirhinal cortex: axonal location of channels and contribution to depolarizing drive during repetitive firing
J. Physiol., August 1, 2007; 582(3): 1179 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. van Drongelen, H. Koch, F. P. Elsen, H. C. Lee, A. Mrejeru, E. Doren, C. J. Marcuccilli, M. Hereld, R. L. Stevens, and J.-M. Ramirez
Role of Persistent Sodium Current in Bursting Activity of Mouse Neocortical Networks In Vitro
J Neurophysiol, November 1, 2006; 96(5): 2564 - 2577.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. J. Kuo, R. H. Lee, L. Zhang, and C. J. Heckman
Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones
J. Physiol., August 1, 2006; 574(3): 819 - 834.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. Aracri, E. Colombo, M. Mantegazza, P. Scalmani, G. Curia, G. Avanzini, and S. Franceschetti
Layer-Specific Properties of the Persistent Sodium Current in Sensorimotor Cortex
J Neurophysiol, June 1, 2006; 95(6): 3460 - 3468.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Magistretti, L. Castelli, L. Forti, and E. D'Angelo
Kinetic and functional analysis of transient, persistent and resurgent sodium currents in rat cerebellar granule cells in situ: an electrophysiological and modelling study
J. Physiol., May 15, 2006; 573(1): 83 - 106.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Enomoto, J. M. Han, C.-F. Hsiao, N. Wu, and S. H. Chandler
Participation of sodium currents in burst generation and control of membrane excitability in mesencephalic trigeminal neurons.
J. Neurosci., March 29, 2006; 26(13): 3412 - 3422.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Astman, M. J. Gutnick, and I. A. Fleidervish
Persistent sodium current in layer 5 neocortical neurons is primarily generated in the proximal axon.
J. Neurosci., March 29, 2006; 26(13): 3465 - 3473.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Golomb, A. Shedmi, R. Curtu, and G. B. Ermentrout
Persistent Synchronized Bursting Activity in Cortical Tissues With Low Magnesium Concentration: A Modeling Study
J Neurophysiol, February 1, 2006; 95(2): 1049 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Keren, N. Peled, and A. Korngreen
Constraining Compartmental Models Using Multiple Voltage Recordings and Genetic Algorithms
J Neurophysiol, December 1, 2005; 94(6): 3730 - 3742.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Ptak, G. G. Zummo, G. F. Alheid, T. Tkatch, D. J. Surmeier, and D. R. McCrimmon
Sodium Currents in Medullary Neurons Isolated from the Pre-Botzinger Complex Region
J. Neurosci., May 25, 2005; 25(21): 5159 - 5170.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. A. Prescott and Y. De Koninck
Integration Time in a Subset of Spinal Lamina I Neurons Is Lengthened by Sodium and Calcium Currents Acting Synergistically to Prolong Subthreshold Depolarization
J. Neurosci., May 11, 2005; 25(19): 4743 - 4754.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Wu, A. Enomoto, S. Tanaka, C.-F. Hsiao, D. Q. Nykamp, E. Izhikevich, and S. H. Chandler
Persistent Sodium Currents in Mesencephalic V Neurons Participate in Burst Generation and Control of Membrane Excitability
J Neurophysiol, May 1, 2005; 93(5): 2710 - 2722.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. Z. Wetmore and S. N. Baker
Post-spike distance-to-threshold trajectories of neurones in monkey motor cortex
J. Physiol., March 15, 2004; 555(3): 831 - 850.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Axmacher and R. Miles
Intrinsic cellular currents and the temporal precision of EPSP-action potential coupling in CA1 pyramidal cells
J. Physiol., March 15, 2004; 555(3): 713 - 725.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. I. Kononenko, L.-R. Shao, and F. E. Dudek
Riluzole-Sensitive Slowly Inactivating Sodium Current in Rat Suprachiasmatic Nucleus Neurons
J Neurophysiol, February 1, 2004; 91(2): 710 - 718.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. E. Garabedian, S. R. Jones, M. M. Merzenich, A. Dale, and C. I. Moore
Band-Pass Response Properties of Rat SI Neurons
J Neurophysiol, September 1, 2003; 90(3): 1379 - 1391.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. A. Del Negro, N. Koshiya, R. J. Butera Jr., and J. C. Smith
Persistent Sodium Current, Membrane Properties and Bursting Behavior of Pre-Botzinger Complex Inspiratory Neurons In Vitro
J Neurophysiol, November 1, 2002; 88(5): 2242 - 2250.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. H. Lee and C. J. Heckman
Essential Role of a Fast Persistent Inward Current in Action Potential Initiation and Control of Rhythmic Firing
J Neurophysiol, January 1, 2001; 85(1): 472 - 475.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
I. Timofeev, F. Grenier, M. Bazhenov, T.J. Sejnowski, and M. Steriade
Origin of Slow Cortical Oscillations in Deafferented Cortical Slabs
Cereb Cortex, December 1, 2000; 10(12): 1185 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. A. Gorelova and C. R. Yang
Dopamine D1/D5 Receptor Activation Modulates a Persistent Sodium Current in Rat Prefrontal Cortical Neurons In Vitro
J Neurophysiol, July 1, 2000; 84(1): 75 - 87.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. D. Bevan and C. J. Wilson
Mechanisms Underlying Spontaneous Oscillation and Rhythmic Firing in Rat Subthalamic Neurons
J. Neurosci., September 1, 1999; 19(17): 7617 - 7628.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. J. Butera Jr., J. Rinzel, and J. C. Smith
Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. I. Bursting Pacemaker Neurons
J Neurophysiol, July 1, 1999; 82(1): 382 - 397.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release
Physiol Rev, July 1, 1999; 79(3): 1019 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
J. MAGISTRETTI and A. ALONSO
Slow Voltage-Dependent Inactivation of a Sustained Sodium Current in Stellate Cells of Rat Entorhinal Cortex Layer II
Ann. N.Y. Acad. Sci., April 30, 1999; 868(1): 84 - 87.
[Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Taverna, G. Sancini, M. Mantegazza, S. Franceschetti, and G. Avanzini
Inhibition of Transient and Persistent Na+ Current Fractions by the New Anticonvulsant Topiramate
J. Pharmacol. Exp. Ther., March 1, 1999; 288(3): 960 - 968.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
T. R. Cummins, J. R. Howe, and S. G. Waxman
Slow Closed-State Inactivation: A Novel Mechanism Underlying Ramp Currents in Cells Expressing the hNE/PN1 Sodium Channel
J. Neurosci., December 1, 1998; 18(23): 9607 - 9619.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. R. Kay, M. Sugimori, and R. Llinas
Kinetic and Stochastic Properties of a Persistent Sodium Current in Mature Guinea Pig Cerebellar Purkinje Cells
J Neurophysiol, September 1, 1998; 80(3): 1167 - 1179.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Astman, M. J. Gutnick, and I. A. Fleidervish
Activation of Protein Kinase C Increases Neuronal Excitability by Regulating Persistent Na+ Current in Mouse Neocortical Slices
J Neurophysiol, September 1, 1998; 80(3): 1547 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Mittmann and C. Alzheimer
Muscarinic Inhibition of Persistent Na+ Current in Rat Neocortical Pyramidal Neurons
J Neurophysiol, March 1, 1998; 79(3): 1579 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. R. Parri and V. Crunelli
Sodium Current in Rat and Cat Thalamocortical Neurons: Role of a Non-Inactivating Component in Tonic and Burst Firing
J. Neurosci., February 1, 1998; 18(3): 854 - 867.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Sawczuk, R. K. Powers, and M. D. Binder
Contribution of Outward Currents to Spike-Frequency Adaptation in Hypoglossal Motoneurons of the Rat
J Neurophysiol, November 1, 1997; 78(5): 2246 - 2253.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C.M.A. Pennartz, M. A. Bierlaagh, and A.M.S. Geurtsen
Cellular Mechanisms Underlying Spontaneous Firing in Rat Suprachiasmatic Nucleus: Involvement of a Slowly Inactivating Component of Sodium Current
J Neurophysiol, October 1, 1997; 78(4): 1811 - 1825.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Golomb and Y. Amitai
Propagating Neuronal Discharges in Neocortical Slices: Computational and Experimental Study
J Neurophysiol, September 1, 1997; 78(3): 1199 - 1211.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online