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The University of Iowa, College of Medicine, Department of Pharmacology, Bowen Science Building, Iowa City, Iowa 52242
Su, X., J. N. Sengupta, and G. F. Gebhart. Effects of opioids on mechanosensitive pelvic nerve afferent fibers innervating the urinary bladder of the rat. J. Neurophysiol. 77: 1566-1580, 1997. A total of 443 pelvic nerve afferent fibers in the L6 dorsal root of the rat were identified by electrical stimulation of the pelvic nerve; 319 (72%) were myelinated A
fibers with a mean conduction velocity (CV) of 11.8 m/s and 124 (28%) were unmyelinated C fibers with mean CV of 1.9 m/s. Two hundred fifty-two fibers (57%) responded to noxious urinary bladder distension (UBD; 80 mmHg); 108 were C fibers (mean CV: 1.9 m/s) and 144 were A fibers (mean CV: 8.2 m/s). Forty-nine UBD-sensitive fibers were further characterized; all gave monotonic increases in firing to increasing distending pressures. Thirty-six fibers (73%) had a low-threshold (LT) for response (mean: 6 mmHg) and 13 fibers (27%) had high-thresholds (HT) for response (mean: 32 mmHg). Responses of 15 fibers to graded UBD (11 LT and 4 HT) were tested before and after instillation of 0.5 ml of 30% xylenes (n = 11) or 5% mustard oil (n = 4) into the bladder. The mean resting activity of 13 fibers significantly increased, and 7 fibers exhibited sensitization of responses to graded UBD 30 min after xylenes or mustard oil instillation. All 4 HT fibers were sensitized; 3 of the 11 LT fibers were sensitized (i.e., gave increased responses to UBD). The effects of opioid receptor agonists were tested on responses to noxious UBD (80 mmHg). Cumulative intraaterial doses of µ-opioid receptor agonists (morphine, 8 mg/kg, and fentanyl, 300 µg/kg) and of -opioid receptor agonists (DPDPE, 300 µg/kg, and SNC-80, 300 µg/kg) did not affect responses to noxious UBD. In contrast, cumulative 16 mg/kg intraarterial doses of the 
-opioid receptor agonists U50,488H, U69,593 and U62,066 dose-dependently attenuated responses to noxious UBD. There were no differences in the dose-response relationships of these drugs on afferent fibers from untreated and xylenes- or mustard oil-treated urinary bladder. These results reveal that there is a greater proportion of UBD-sensitive fibers in the L6 dorsal root (57%) than in the S1 dorsal root of the rat (38%; a previous study). The attenuation of responses to UBD by , but not µ or opioid receptor agonists suggests a potential use for peripherally acting opioid receptor agonists in the control of urinary bladder pain.
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M. S. Gold, L. Zhang, D. L. Wrigley, and R. J. Traub Prostaglandin E2 Modulates TTX-R INa in Rat Colonic Sensory Neurons J Neurophysiol, September 1, 2002; 88(3): 1512 - 1522. [Abstract] [Full Text] [PDF]
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X. Su, S. K. Joshi, S. Kardos, and G. F. Gebhart Sodium Channel Blocking Actions of the kappa -Opioid Receptor Agonist U50,488 Contribute to Its Visceral Antinociceptive Effects J Neurophysiol, March 1, 2002; 87(3): 1271 - 1279. [Abstract] [Full Text] [PDF]
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T. Mitsui, H. Kakizaki, S. Matsuura, K. Ameda, M. Yoshioka, and T. Koyanagi Afferent Fibers of the Hypogastric Nerves Are Involved in the Facilitating Effects of Chemical Bladder Irritation in Rats J Neurophysiol, November 1, 2001; 86(5): 2276 - 2284. [Abstract] [Full Text] [PDF]
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Y. Ji and R. J. Traub Spinal NMDA Receptors Contribute to Neuronal Processing of Acute Noxious and Nonnoxious Colorectal Stimulation in the Rat J Neurophysiol, October 1, 2001; 86(4): 1783 - 1791. [Abstract] [Full Text] [PDF]
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 X Su, M B Burton, and G F Gebhart Effects of octreotide on responses to colorectal distension in the rat Gut, May 1, 2001; 48(5): 676 - 682. [Abstract] [Full Text] [PDF]
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V. K. Shea, R. Cai, B. Crepps, J. L. Mason, and E. R. Perl Sensory Fibers of the Pelvic Nerve Innervating the Rat's Urinary Bladder J Neurophysiol, October 1, 2000; 84(4): 1924 - 1933. [Abstract] [Full Text] [PDF]
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X. Su, R. E. Wachtel, and G. F. Gebhart Mechanosensitive Potassium Channels in Rat Colon Sensory Neurons J Neurophysiol, August 1, 2000; 84(2): 836 - 843. [Abstract] [Full Text] [PDF]
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N. Ozaki, J. N. Sengupta, and G. F. Gebhart Differential Effects of {micro}-, delta -, and kappa -Opioid Receptor Agonists on Mechanosensitive Gastric Vagal Afferent Fibers in the Rat J Neurophysiol, April 1, 2000; 83(4): 2209 - 2216. [Abstract] [Full Text] [PDF]
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X. Su, V. Julia, and G. F. Gebhart Effects of Intracolonic Opioid Receptor Agonists on Polymodal Pelvic Nerve Afferent Fibers in the Rat J Neurophysiol, February 1, 2000; 83(2): 963 - 970. [Abstract] [Full Text] [PDF]
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N. Ozaki, J. N. Sengupta, and G. F. Gebhart Mechanosensitive Properties of Gastric Vagal Afferent Fibers in the Rat J Neurophysiol, November 1, 1999; 82(5): 2210 - 2220. [Abstract] [Full Text] [PDF]
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X. Su, R. E. Wachtel, and G. F. Gebhart Inhibition of Calcium Currents in Rat Colon Sensory Neurons by K- But Not µ- or delta -Opioids J Neurophysiol, December 1, 1998; 80(6): 3112 - 3119. [Abstract] [Full Text] [PDF]
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X. Su and G. F. Gebhart Mechanosensitive Pelvic Nerve Afferent Fibers Innervating the Colon of the Rat are Polymodal in Character J Neurophysiol, November 1, 1998; 80(5): 2632 - 2644. [Abstract] [Full Text] [PDF]
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M. B. Burton and G. F. Gebhart Effects of Kappa-Opioid Receptor Agonists on Responses to Colorectal Distension in Rats with and without Acute Colonic Inflammation J. Pharmacol. Exp. Ther., May 1, 1998; 285(2): 707 - 715. [Abstract] [Full Text]
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C. Roza, J. M. A. Laird, and F. Cervero Spinal Mechanisms Underlying Persistent Pain and Referred Hyperalgesia in Rats With an Experimental Ureteric Stone J Neurophysiol, April 1, 1998; 79(4): 1603 - 1612. [Abstract] [Full Text] [PDF]
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X. Su, J. N. Sengupta, and G. F. Gebhart Effects of Kappa Opioid Receptor-Selective Agonists on Responses of Pelvic Nerve Afferents to Noxious Colorectal Distension J Neurophysiol, August 1, 1997; 78(2): 1003 - 1012. [Abstract] [Full Text] [PDF]
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