JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 78: 43-50, 1997;
0022-3077/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Twitchell, W.
Right arrow Articles by Mackie, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Twitchell, W.
Right arrow Articles by Mackie, K.

The Journal of Neurophysiology Vol. 78 No. 1 July 1997, pp. 43-50
Copyright ©1997 The American Physiological Society

Cannabinoids Inhibit N- and P/Q-Type Calcium Channels in Cultured Rat Hippocampal Neurons

W. Twitchell1, S. Brown1, and K. Mackie1, 2

1 Department of Anesthesiology and 2 Department of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, Washington 98195

Twitchell, W., S. Brown, and K. Mackie. Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J. Neurophysiol. 78: 43-50, 1997. Cannabinoids and their analogues have been found to inhibit N- and P/Q-type Ca2+ currents in cell lines and sympathetic neurons transfected with cannabinoid CB1 receptor. However, the effects of cannabinoids on Ca2+ currents in the CNS are largely unexplored. In this study we investigated whether these compounds inhibit Ca2+ channels in cultured rat hippocampal neurons. With the use of antibodies directed against the amino-terminus of the CB1 receptor, we found that in 5-day cultures pyramidally shaped neurons expressed somatic CB1 receptors, whereas in 4-wk cultures the receptor was predomintely located on neurites. In early cultures, the cannabimimetic WIN 55,212-2 reversibly inhibited whole cell Ba2+ current in a concentration-dependent (K1/2 = 21 nM) and pertussis-toxin-sensitive fashion. Inhibition was reduced by the CB1 antagonist SR141716. The current was unaffected by the nonpsychoactive enantiomer WIN 55,212-3. Maximal inhibition by the nonclassical cannabinoid agonist CP 55,940 and by an endogenous cannabinoid, anandamide, were similar to that seen with maximal concentrations of WIN 55,212-2. The Ba2+ current modulated by cannabinoids was carried by N-type (omega -conotoxin-GVIA-sensitive) and P/Q-type (omega -conotoxin-MVIIC-sensitive) channels. These results demonstrate cannabinoid-receptor-mediated inhibition of distinct Ca2+ channels in central neurons. Because the channels that underlie these currents are chiefly located presynaptically, and are required for evoked neurotransmitter release, our results suggest a major role for cannabinoids (endogenous and exogenous) in the modulation of synaptic transmission at CNS synapses.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Fu, J. Kim, F. Oveisi, G. Astarita, and D. Piomelli
Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R45 - R50.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
S. C. Azad, J. Kurz, G. Marsicano, B. Lutz, W. Zieglgansberger, and G. Rammes
Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala
Learn. Mem., March 5, 2008; 15(3): 143 - 152.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. B. Ali
Presynaptic Inhibition of GABAA Receptor-Mediated Unitary IPSPs by Cannabinoid Receptors at Synapses Between CCK-Positive Interneurons in Rat Hippocampus
J Neurophysiol, August 1, 2007; 98(2): 861 - 869.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Huang, C. Acuna-Goycolea, Y. Li, H. M. Cheng, K. Obrietan, and A. N. van den Pol
Cannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal
J. Neurosci., May 2, 2007; 27(18): 4870 - 4881.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. Sanchez-Pastor, X. Trujillo, M. Huerta, and F. Andrade
Effects of Cannabinoids on Synaptic Transmission in the Frog Neuromuscular Junction
J. Pharmacol. Exp. Ther., May 1, 2007; 321(2): 439 - 445.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Fu, G. Astarita, S. Gaetani, J. Kim, B. F. Cravatt, K. Mackie, and D. Piomelli
Food Intake Regulates Oleoylethanolamide Formation and Degradation in the Proximal Small Intestine
J. Biol. Chem., January 12, 2007; 282(2): 1518 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Akerman, P. R. Holland, and P. J. Goadsby
Cannabinoid (CB1) Receptor Activation Inhibits Trigeminovascular Neurons
J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 64 - 71.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. E. Hofmann, B. Nahir, and C. J. Frazier
Endocannabinoid-Mediated Depolarization-Induced Suppression of Inhibition in Hilar Mossy Cells of the Rat Dentate Gyrus
J Neurophysiol, November 1, 2006; 96(5): 2501 - 2512.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
N. Sang and C. Chen
Lipid Signaling and Synaptic Plasticity
Neuroscientist, October 1, 2006; 12(5): 425 - 434.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. H. Kim, S. J. Won, X. O. Mao, C. Ledent, K. Jin, and D. A. Greenberg
Role for Neuronal Nitric-Oxide Synthase in Cannabinoid-Induced Neurogenesis
J. Pharmacol. Exp. Ther., October 1, 2006; 319(1): 150 - 154.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
L. J. Sim-Selley, N. S. Schechter, W. K. Rorrer, G. D. Dalton, J. Hernandez, B. R. Martin, and D. E. Selley
Prolonged Recovery Rate of CB1 Receptor Adaptation after Cessation of Long-Term Cannabinoid Administration
Mol. Pharmacol., September 1, 2006; 70(3): 986 - 996.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G. Cobellis, G. Cacciola, D. Scarpa, R. Meccariello, R. Chianese, M. F. Franzoni, K. Mackie, R. Pierantoni, and S. Fasano
Endocannabinoid System in Frog and Rodent Testis: Type-1 Cannabinoid Receptor and Fatty Acid Amide Hydrolase Activity in Male Germ Cells
Biol Reprod, July 1, 2006; 75(1): 82 - 89.
[Abstract] [Full Text] [PDF]

Home page
 J PsychopharmacolHome page
M. J. Khodayar, B. Shafaghi, N. Naderi, and M.-R. Zarrindast
Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: possible interactions
J Psychopharmacol, January 1, 2006; 20(1): 67 - 74.
[Abstract] [PDF]

Home page
 J. Neurophysiol.Home page
L. M. Johanek and D. A. Simone
Cannabinoid Agonist, CP 55,940, Prevents Capsaicin-Induced Sensitization of Spinal Cord Dorsal Horn Neurons
J Neurophysiol, February 1, 2005; 93(2): 989 - 997.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
F. RODRIGUEZ de FONSECA, I. DEL ARCO, F. J. BERMUDEZ-SILVA, A. BILBAO, A. CIPPITELLI, and M. NAVARRO
THE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY
Alcohol Alcohol., January 1, 2005; 40(1): 2 - 14.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. M. Newton, C. J. Orr, M. J. Wallace, C. Kim, H.-S. Shin, and R. O. Messing
Deletion of N-Type Calcium Channels Alters Ethanol Reward and Reduces Ethanol Consumption in Mice
J. Neurosci., November 3, 2004; 24(44): 9862 - 9869.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. J. A. Helliwell, L. W. Chamley, K. Blake-Palmer, M. D. Mitchell, J. Wu, C. S. Kearn, and M. Glass
Characterization of the Endocannabinoid System in Early Human Pregnancy
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5168 - 5174.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
B. Szabo, M. Than, D. Thorn, and I. Wallmichrath
Analysis of the Effects of Cannabinoids on Synaptic Transmission between Basket and Purkinje Cells in the Cerebellar Cortex of the Rat
J. Pharmacol. Exp. Ther., September 1, 2004; 310(3): 915 - 925.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Hirasawa, Y. Schwab, S. Natah, C. J. Hillard, K. Mackie, K. A. Sharkey, and Q. J. Pittman
Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain
J. Physiol., September 1, 2004; 559(2): 611 - 624.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Kushmerick, G. D. Price, H. Taschenberger, N. Puente, R. Renden, J. I. Wadiche, R. M. Duvoisin, P. Grandes, and H. von Gersdorff
Retroinhibition of Presynaptic Ca2+ Currents by Endocannabinoids Released via Postsynaptic mGluR Activation at a Calyx Synapse
J. Neurosci., June 30, 2004; 24(26): 5955 - 5965.
[Abstract] [Full Text] [PDF]

Home page
 JAOA: Journal of the American Osteopathic AssociationHome page
J. M. McPartland
Travell Trigger Points--Molecular and Osteopathic Perspectives
J Am Osteopath Assoc, June 1, 2004; 104(6): 244 - 249.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Daniel, A. Rancillac, and F. Crepel
Mechanisms underlying cannabinoid inhibition of presynaptic Ca2+ influx at parallel fibre synapses of the rat cerebellum
J. Physiol., May 15, 2004; 557(1): 159 - 174.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. A. Khasabova, C. Harding-Rose, D. A. Simone, and V. S. Seybold
Differential Effects of CB1 and Opioid Agonists on Two Populations of Adult Rat Dorsal Root Ganglion Neurons
J. Neurosci., February 18, 2004; 24(7): 1744 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y.-C. Liang, C.-C. Huang, K.-S. Hsu, and T. Takahashi
Cannabinoid-induced presynaptic inhibition at the primary afferent trigeminal synapse of juvenile rat brainstem slices
J. Physiol., February 15, 2004; 555(1): 85 - 96.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. I. Davis, J. Ronesi, and D. M. Lovinger
A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells
J. Biol. Chem., December 5, 2003; 278(49): 48973 - 48980.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. H. Brager, P. W. Luther, F. Erdelyi, G. Szabo, and B. E. Alger
Regulation of Exocytosis from Single Visualized GABAergic Boutons in Hippocampal Slices
J. Neurosci., November 19, 2003; 23(33): 10475 - 10486.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. B. El-Remessy, I. E. Khalil, S. Matragoon, G. Abou-Mohamed, N.-J. Tsai, P. Roon, R. B. Caldwell, R. W. Caldwell, K. Green, and G. I. Liou
Neuroprotective Effect of(-){Delta}9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-D-Aspartate-Induced Retinal Neurotoxicity: Involvement of Peroxynitrite
Am. J. Pathol., November 1, 2003; 163(5): 1997 - 2008.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
G. Pryce, Z. Ahmed, D. J. R. Hankey, S. J. Jackson, J. L. Croxford, J. M. Pocock, C. Ledent, A. Petzold, A. J. Thompson, G. Giovannoni, et al.
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
Brain, October 1, 2003; 126(10): 2191 - 2202.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. D. Brenowitz and W. G. Regehr
Calcium Dependence of Retrograde Inhibition by Endocannabinoids at Synapses onto Purkinje Cells
J. Neurosci., July 16, 2003; 23(15): 6373 - 6384.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
T. F. FREUND, I. KATONA, and D. PIOMELLI
Role of Endogenous Cannabinoids in Synaptic Signaling
Physiol Rev, July 1, 2003; 83(3): 1017 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
H. L. Agler, J. Evans, H. M. Colecraft, and D. T. Yue
Custom Distinctions in the Interaction of G-protein {beta} Subunits with N-type (CaV2.2) Versus P/Q-type (CaV2.1) Calcium Channels
J. Gen. Physiol., May 27, 2003; 121(6): 495 - 510.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Straiker and J. M. Sullivan
Cannabinoid Receptor Activation Differentially Modulates Ion Channels in Photoreceptors of the Tiger Salamander
J Neurophysiol, May 1, 2003; 89(5): 2647 - 2654.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Tripathy, K. Kleppinger-Sparace, R. A. Dixon, and K. D. Chapman
N-Acylethanolamine Signaling in Tobacco Is Mediated by a Membrane-Associated, High-Affinity Binding Protein
Plant Physiology, April 1, 2003; 131(4): 1781 - 1791.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
S. C. Azad, M. Eder, G. Marsicano, B. Lutz, W. Zieglgansberger, and G. Rammes
Activation of the Cannabinoid Receptor Type 1 Decreases Glutamatergic and GABAergic Synaptic Transmission in the Lateral Amygdala of the Mouse
Learn. Mem., March 1, 2003; 10(2): 116 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Parmentier-Batteur, K. Jin, L. Xie, X. O. Mao, and D. A. Greenberg
DNA Microarray Analysis of Cannabinoid Signaling in Mouse Brain in Vivo
Mol. Pharmacol., October 1, 2002; 62(4): 828 - 835.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Gubellini, B. Picconi, M. Bari, N. Battista, P. Calabresi, D. Centonze, G. Bernardi, A. Finazzi-Agro, and M. Maccarrone
Experimental Parkinsonism Alters Endocannabinoid Degradation: Implications for Striatal Glutamatergic Transmission
J. Neurosci., August 15, 2002; 22(16): 6900 - 6907.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Trettel and E. S. Levine
Cannabinoids Depress Inhibitory Synaptic Inputs Received by Layer 2/3 Pyramidal Neurons of the Neocortex
J Neurophysiol, July 1, 2002; 88(1): 534 - 539.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Ohno-Shosaku, H. Tsubokawa, I. Mizushima, N. Yoneda, A. Zimmer, and M. Kano
Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses
J. Neurosci., May 15, 2002; 22(10): 3864 - 3872.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. I. Wilson and R. A. Nicoll
Endocannabinoid Signaling in the Brain
Science, April 26, 2002; 296(5568): 678 - 682.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Yoshida, K. Hashimoto, A. Zimmer, T. Maejima, K. Araishi, and M. Kano
The Cannabinoid CB1 Receptor Mediates Retrograde Signals for Depolarization-Induced Suppression of Inhibition in Cerebellar Purkinje Cells
J. Neurosci., March 1, 2002; 22(5): 1690 - 1697.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C.-C. Huang, Y.-L. Chen, S.-W. Lo, and K.-S. Hsu
Activation of cAMP-Dependent Protein Kinase Suppresses the Presynaptic Cannabinoid Inhibition of Glutamatergic Transmission at Corticostriatal Synapses
Mol. Pharmacol., March 1, 2002; 61(3): 578 - 585.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Diana, C. Levenes, K. Mackie, and A. Marty
Short-Term Retrograde Inhibition of GABAergic Synaptic Currents in Rat Purkinje Cells Is Mediated by Endogenous Cannabinoids
J. Neurosci., January 1, 2002; 22(1): 200 - 208.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Kelly and V. Chapman
Selective Cannabinoid CB1 Receptor Activation Inhibits Spinal Nociceptive Transmission In Vivo
J Neurophysiol, December 1, 2001; 86(6): 3061 - 3064.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Nie and D. L. Lewis
Structural Domains of the CB1 Cannabinoid Receptor That Contribute to Constitutive Activity and G-Protein Sequestration
J. Neurosci., November 15, 2001; 21(22): 8758 - 8764.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
L. Ferraro, M. C. Tomasini, G. L. Gessa, B. W. Bebe, S. Tanganelli, and T. Antonelli
The Cannabinoid Receptor Agonist WIN 55,212-2 Regulates Glutamate Transmission in Rat Cerebral Cortex: an In Vivo and In Vitro Study
Cereb Cortex, August 1, 2001; 11(8): 728 - 733.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Morisset and L. Urban
Cannabinoid-Induced Presynaptic Inhibition of Glutamatergic EPSCs in Substantia Gelatinosa Neurons of the Rat Spinal Cord
J Neurophysiol, July 1, 2001; 86(1): 40 - 48.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. J. Rodriguez, K. Mackie, and V. M. Pickel
Ultrastructural Localization of the CB1 Cannabinoid Receptor in {micro}-Opioid Receptor Patches of the Rat Caudate Putamen Nucleus
J. Neurosci., February 1, 2001; 21(3): 823 - 833.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. Gerdeman and D. M. Lovinger
CB1 Cannabinoid Receptor Inhibits Synaptic Release of Glutamate in Rat Dorsolateral Striatum
J Neurophysiol, January 1, 2001; 85(1): 468 - 471.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Robbe, G. Alonso, F. Duchamp, J. Bockaert, and O. J. Manzoni
Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens
J. Neurosci., January 1, 2001; 21(1): 109 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. E. Hampson and S. A. Deadwyler
Cannabinoids Reveal the Necessity of Hippocampal Neural Encoding for Short-Term Memory in Rats
J. Neurosci., December 1, 2000; 20(23): 8932 - 8942.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. E. Hampson, J. Mu, and S. A. Deadwyler
Cannabinoid and Kappa Opioid Receptors Reduce Potassium K Current via Activation of Gs Proteins in Cultured Hippocampal Neurons
J Neurophysiol, November 1, 2000; 84(5): 2356 - 2364.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Y. Ho, A. Stadnicka, P. L. Prather, A. R. Buckley, L. L. Current, Z. J. Bosnjak, and W.-M. Kwok
Cannabinoid CB1 Receptor-Mediated Inhibition of Prolactin Release and Signaling Mechanisms in GH4C1 Cells
Endocrinology, May 1, 2000; 141(5): 1675 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
J. M. Sullivan
Cellular and Molecular Mechanisms Underlying Learning and Memory Impairments Produced by Cannabinoids
Learn. Mem., May 1, 2000; 7(3): 132 - 139.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
A. F. Hoffman and C. R. Lupica
Mechanisms of Cannabinoid Inhibition of GABAA Synaptic Transmission in the Hippocampus
J. Neurosci., April 1, 2000; 20(7): 2470 - 2479.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. A. Takahashi and D. J. Linden
Cannabinoid Receptor Modulation of Synapses Received by Cerebellar Purkinje Cells
J Neurophysiol, March 1, 2000; 83(3): 1167 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. W. Vaughan, M. Connor, E. E. Bagley, and M. J. Christie
Actions of Cannabinoids on Membrane Properties and Synaptic Transmission in Rat Periaqueductal Gray Neurons In Vitro
Mol. Pharmacol., February 1, 2000; 57(2): 288 - 295.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
P. Schweitzer
Cannabinoids Decrease the K+ M-Current in Hippocampal CA1 Neurons
J. Neurosci., January 1, 2000; 20(1): 51 - 58.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Vasquez and D. L. Lewis
The CB1 Cannabinoid Receptor Can Sequester G-Proteins, Making Them Unavailable to Couple to Other Receptors
J. Neurosci., November 1, 1999; 19(21): 9271 - 9280.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. G. Netzeband, S. M. Conroy, K. L. Parsons, and D. L. Gruol
Cannabinoids Enhance NMDA-Elicited Ca2+ Signals in Cerebellar Granule Neurons in Culture
J. Neurosci., October 15, 1999; 19(20): 8765 - 8777.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. M. Sullivan
Mechanisms of Cannabinoid-Receptor-Mediated Inhibition of Synaptic Transmission in Cultured Hippocampal Pyramidal Neurons
J Neurophysiol, September 1, 1999; 82(3): 1286 - 1294.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J. P. Roche, S. Bounds, S. Brown, and K. Mackie
A Mutation in t