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RAPID COMMUNICATION
Departments of Neurology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203
Merlin, Lisa R. and Robert K. S. Wong. Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro. J. Neurophysiol. 78: 539-544, 1997. In guinea pig hippocampal slices, picrotoxin elicited spontaneous epileptiform bursts 300-550 ms in duration. Additional application of (R,S)-3,5-dihydroxyphenylglycine or (S)-3-hydroxyphenylglycine, agonists specific for group I metabotropic glutamate receptors(mGluRs), or (1S,3R)-1-aminocyclopentane-1,3-dicarboxylicacid, a broad-spectrum mGluR agonist, converted picrotoxin-induced interictal bursts into prolonged discharges measured on the order of seconds. The prolonged discharges induced by selective group I mGluR agonist continued to be produced for hours after agonist removal. The antagonists (S)-4-carboxyphenylglycine and (+)-
-methyl-4-carboxyphenylglycine had no effect on the duration of picrotoxin-induced interictal bursts. However, after agonist exposure, the persistent prolonged discharges occurring in the absence of agonist were reversibly suppressed by the antagonists, suggesting that the activity is maintained via endogenous activation of group I mGluRs by synaptically released glutamate. Our results suggest that, under some conditions, activation of group I mGluRs produces long-lasting enhancement of synaptic responses, mediated at least in part by autopotentiation of the group I mGluR response itself, which may result in the production of seizure discharges and contribute to epileptogenesis.
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 S.-C. Chuang, W. Zhao, R. Bauchwitz, Q. Yan, R. Bianchi, and R. K. S. Wong Prolonged Epileptiform Discharges Induced by Altered Group I Metabotropic Glutamate Receptor-Mediated Synaptic Responses in Hippocampal Slices of a Fragile X Mouse Model J. Neurosci., August 31, 2005; 25(35): 8048 - 8055. [Abstract] [Full Text] [PDF]
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M. Wu, T. Hajszan, C. Xu, C. Leranth, and M. Alreja Group I Metabotropic Glutamate Receptor Activation Produces a Direct Excitation of Identified Septohippocampal Cholinergic Neurons J Neurophysiol, August 1, 2004; 92(2): 1216 - 1225. [Abstract] [Full Text] [PDF]
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M. J. Rico and L. R. Merlin Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts J Neurophysiol, May 1, 2004; 91(5): 2385 - 2388. [Abstract] [Full Text] [PDF]
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W. Zhao, R. Bianchi, M. Wang, and R. K. S. Wong Extracellular Signal-Regulated Kinase 1/2 Is Required for the Induction of Group I Metabotropic Glutamate Receptor-Mediated Epileptiform Discharges J. Neurosci., January 7, 2004; 24(1): 76 - 84. [Abstract] [Full Text] [PDF]
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R. Stoop, F. Conquet, B. Zuber, L. L. Voronin, and E. Pralong Activation of Metabotropic Glutamate 5 and NMDA Receptors Underlies the Induction of Persistent Bursting and Associated Long-Lasting Changes in CA3 Recurrent Connections J. Neurosci., July 2, 2003; 23(13): 5634 - 5644. [Abstract] [Full Text] [PDF]
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A. C. Lee, R. K. S. Wong, S.-C. Chuang, H.-S. Shin, and R. Bianchi Role of Synaptic Metabotropic Glutamate Receptors in Epileptiform Discharges in Hippocampal Slices J Neurophysiol, October 1, 2002; 88(4): 1625 - 1633. [Abstract] [Full Text] [PDF]
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A. M. Watabe, H. J. Carlisle, and T. J. O'Dell Postsynaptic Induction and Presynaptic Expression of Group 1 mGluR-Dependent LTD in the Hippocampal CA1 Region J Neurophysiol, March 1, 2002; 87(3): 1395 - 1403. [Abstract] [Full Text] [PDF]
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L. R. Merlin Differential Roles for mGluR1 and mGluR5 in the Persistent Prolongation of Epileptiform Bursts J Neurophysiol, January 1, 2002; 87(1): 621 - 625. [Abstract] [Full Text] [PDF]
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E. D. Martin, A. Araque, and W. Buno Synaptic Regulation of the Slow Ca2+-Activated K+ Current in Hippocampal CA1 Pyramidal Neurons: Implication in Epileptogenesis J Neurophysiol, December 1, 2001; 86(6): 2878 - 2886. [Abstract] [Full Text] [PDF]
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S.-C. Chuang, R. Bianchi, D. Kim, H.-S. Shin, and R. K. S. Wong Group I Metabotropic Glutamate Receptors Elicit Epileptiform Discharges in the Hippocampus through PLC{beta}1 Signaling J. Neurosci., August 15, 2001; 21(16): 6387 - 6394. [Abstract] [Full Text] [PDF]
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R. Kohling, M. Vreugdenhil, E. Bracci, and J. G. R. Jefferys Ictal Epileptiform Activity Is Facilitated by Hippocampal GABAA Receptor-Mediated Oscillations J. Neurosci., September 15, 2000; 20(18): 6820 - 6829. [Abstract] [Full Text] [PDF]
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S.-C. Chuang, R. Bianchi, and R. K. S. Wong Group I mGluR Activation Turns on a Voltage-Gated Inward Current in Hippocampal Pyramidal Cells J Neurophysiol, May 1, 2000; 83(5): 2844 - 2853. [Abstract] [Full Text] [PDF]
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N. B. Keele, F. Zinebi, V. Neugebauer, and P. Shinnick-Gallagher Epileptogenesis Up-Regulates Metabotropic Glutamate Receptor Activation of Sodium-Calcium Exchange Current in the Amygdala J Neurophysiol, April 1, 2000; 83(4): 2458 - 2462. [Abstract] [Full Text] [PDF]
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S. M. Galoyan and L. R. Merlin Long-Lasting Potentiation of Epileptiform Bursts by Group I mGluRs Is NMDA Receptor Independent J Neurophysiol, April 1, 2000; 83(4): 2463 - 2467. [Abstract] [Full Text] [PDF]
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C. Borck and J. G. R. Jefferys Seizure-Like Events in Disinhibited Ventral Slices of Adult Rat Hippocampus J Neurophysiol, November 1, 1999; 82(5): 2130 - 2142. [Abstract] [Full Text] [PDF]
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L. R. Merlin Group I mGluR-Mediated Silent Induction of Long-Lasting Epileptiform Discharges J Neurophysiol, August 1, 1999; 82(2): 1078 - 1081. [Abstract] [Full Text] [PDF]
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N. B. Keele, V. Neugebauer, and P. Shinnick-Gallagher Differential Effects of Metabotropic Glutamate Receptor Antagonists on Bursting Activity in the Amygdala J Neurophysiol, May 1, 1999; 81(5): 2056 - 2065. [Abstract] [Full Text] [PDF]
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L. R. Merlin, P. J. Bergold, and R. K. S. Wong Requirement of Protein Synthesis for Group I mGluR-Mediated Induction of Epileptiform Discharges J Neurophysiol, August 1, 1998; 80(2): 989 - 993. [Abstract] [Full Text] [PDF]
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