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J Neurophysiol 78: 561-566, 1997;
0022-3077/97 $5.00
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The Journal of Neurophysiology Vol. 78 No. 1 July 1997, pp. 561-566
Copyright ©1997 The American Physiological Society

RAPID COMMUNICATION


Adrenoceptor-Mediated Elevation of Ambient GABA Levels Activates Presynaptic GABAB Receptors in Rat Sensorimotor Cortex

Ben D. Bennett, John R. Huguenard, and David A. Prince

Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305

Bennett, Ben D., John R. Huguenard, and David A. Prince. Adrenoceptor-mediated elevation of ambient GABA levels activates presynaptic GABAB receptors in rat sensorimotor cortex. J. Neurophysiol. 78: 561-566, 1997. At inhibitory synapses in the mature neocortex and hippocampus in vitro, spontaneous action-potential-dependent and -independent release of gamma -aminobutyric acid (GABA) activates postsynaptic GABAA receptors but not pre- or postsynaptic GABAB receptors. Elevation of synaptic GABA levels with pharmacological agents or electrical stimulation can cause activation of GABAB receptors, but the physiological conditions under which such activation occurs need further elucidation. In rodent sensorimotor cortex, epinephrine produced a depression in the amplitude of evoked monosynaptic inhibitory postsynaptic currents (IPSCs) and a concomitant, adrenoceptor-mediated increase in the frequency of spontaneous IPSCs. Blockade of GABAB receptors prevented the depression of evoked IPSC amplitude by epinephrine but did not affect the increase in spontaneous IPSC frequency. These data show that adrenoceptor-mediated increases in spontaneous IPSCs can cause activation of presynaptic GABAB receptors and indirectly modulate impulse-related GABA release, presumably through elevation of synaptic GABA levels.




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