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RAPID COMMUNICATION
Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974; and Department of Physics, University of California, La Jolla, California 92093
Fee, Michale S., Partha P. Mitra, and David Kleinfeld. Central versus peripheral determinants of patterned spike activity in rat vibrissa cortex during whisking. J. Neurophysiol. 78: 1144-1149, 1997. We report on the relationship between single-unit activity in primary somatosensory vibrissa cortex of rat and the rhythmic movement of vibrissae. Animals were trained to whisk freely in air in search of food. Electromyographic (EMG) recordings from the mystatial pads served as a reference for the position of the vibrissae. A fast, oscillatory component in single-unit spike trains is correlated with vibrissa position within the whisk cycle. The phase of the correlation for different units is broadly distributed. A second, slowly varying component of spike activity correlates with the amplitude of the whisk cycle. For some units, the phase and amplitude correlations were of sufficient strength to allow the position of the whiskers to be accurately predicted from a single spike train. To determine whether the observed patterned spike activity was driven by motion of the vibrissae, as opposed to central pathways, we reversibly blocked the contralateral facial motor nerve during the behavioral task so that the rat whisked only on the ipsilateral side. The ipsilateral EMG served as a reliable reference signal. The fast, oscillatory component of the spike-EMG correlation disappears when the facial motor nerve is blocked. This implies that the position of vibrissae within a cycle is encoded through direct sensory activation. The slowly varying component of the spike-EMG correlation is unaffected by the block. This implies that the amplitude of whisking is likely to be mediated by corollary discharge. Our results suggest that motor cortex does not relay a reference signal to sensory cortex for positional information of the vibrissae during whisking.
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P. Melzer, R. N. S. Sachdev, N. Jenkinson, and F. F. Ebner Stimulus Frequency Processing in Awake Rat Barrel Cortex. J. Neurosci., November 22, 2006; 26(47): 12198 - 12205. [Abstract] [Full Text] [PDF]
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R. B. Towal and M. J. Hartmann Right-left asymmetries in the whisking behavior of rats anticipate head movements. J. Neurosci., August 23, 2006; 26(34): 8838 - 8846. [Abstract] [Full Text] [PDF]
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P. M. Knutsen, M. Pietr, and E. Ahissar Haptic Object Localization in the Vibrissal System: Behavior and Performance. J. Neurosci., August 15, 2006; 26(33): 8451 - 8464. [Abstract] [Full Text] [PDF]
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M. J. Higley and D. Contreras Balanced Excitation and Inhibition Determine Spike Timing during Frequency Adaptation J. Neurosci., January 11, 2006; 26(2): 448 - 457. [Abstract] [Full Text] [PDF]
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 M. A. L Nicolelis Computing with thalamocortical ensembles during different behavioural states J. Physiol., July 1, 2005; 566(1): 37 - 47. [Abstract] [Full Text] [PDF]
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M. C. Wiest, N. Bentley, and M. A. L. Nicolelis Heterogeneous Integration of Bilateral Whisker Signals by Neurons in Primary Somatosensory Cortex of Awake Rats J Neurophysiol, May 1, 2005; 93(5): 2966 - 2973. [Abstract] [Full Text] [PDF]
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P. M. Knutsen, D. Derdikman, and E. Ahissar Tracking Whisker and Head Movements in Unrestrained Behaving Rodents J Neurophysiol, April 1, 2005; 93(4): 2294 - 2301. [Abstract] [Full Text] [PDF]
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K. F. Ahrens and D. Kleinfeld Current Flow in Vibrissa Motor Cortex Can Phase-Lock With Exploratory Rhythmic Whisking in Rat J Neurophysiol, September 1, 2004; 92(3): 1700 - 1707. [Abstract] [Full Text] [PDF]
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 K. Ganguly and D. Kleinfeld Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat PNAS, August 17, 2004; 101(33): 12348 - 12353. [Abstract] [Full Text] [PDF]
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C. I. Moore Frequency-Dependent Processing in the Vibrissa Sensory System J Neurophysiol, June 1, 2004; 91(6): 2390 - 2399. [Abstract] [Full Text] [PDF]
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Q.-T. Nguyen, R. Wessel, and D. Kleinfeld Developmental regulation of active and passive membrane properties in rat vibrissa motoneurones J. Physiol., April 1, 2004; 556(1): 203 - 219. [Abstract] [Full Text] [PDF]
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J. A. Hartings, S. Temereanca, and D. J. Simons Processing of Periodic Whisker Deflections By Neurons in the Ventroposterior Medial and Thalamic Reticular Nuclei J Neurophysiol, November 1, 2003; 90(5): 3087 - 3094. [Abstract] [Full Text] [PDF]
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R. W. Berg and D. Kleinfeld Vibrissa Movement Elicited by Rhythmic Electrical Microstimulation to Motor Cortex in the Aroused Rat Mimics Exploratory Whisking J Neurophysiol, November 1, 2003; 90(5): 2950 - 2963. [Abstract] [Full Text] [PDF]
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E. Arabzadeh, R. S. Petersen, and M. E. Diamond Encoding of Whisker Vibration by Rat Barrel Cortex Neurons: Implications for Texture Discrimination J. Neurosci., October 8, 2003; 23(27): 9146 - 9154. [Abstract] [Full Text] [PDF]
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C. E. Garabedian, S. R. Jones, M. M. Merzenich, A. Dale, and C. I. Moore Band-Pass Response Properties of Rat SI Neurons J Neurophysiol, September 1, 2003; 90(3): 1379 - 1391. [Abstract] [Full Text] [PDF]
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R. W. Berg and D. Kleinfeld Rhythmic Whisking by Rat: Retraction as Well as Protraction of the Vibrissae Is Under Active Muscular Control J Neurophysiol, January 1, 2003; 89(1): 104 - 117. [Abstract] [Full Text] [PDF]
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E. Ahissar and D. Kleinfeld Closed-loop Neuronal Computations: Focus on Vibrissa Somatosensation in Rat Cereb Cortex, January 1, 2003; 13(1): 53 - 62. [Abstract] [Full Text] [PDF]
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K. F. Ahrens, H. Levine, H. Suhl, and D. Kleinfeld Spectral mixing of rhythmic neuronal signals in sensory cortex PNAS, November 12, 2002; 99(23): 15176 - 15181. [Abstract] [Full Text] [PDF]
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C. C. H. Petersen Short-Term Dynamics of Synaptic Transmission Within the Excitatory Neuronal Network of Rat Layer 4 Barrel Cortex J Neurophysiol, June 1, 2002; 87(6): 2904 - 2914. [Abstract] [Full Text] [PDF]
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S. M. O'Connor, R. W. Berg, and D. Kleinfeld Coherent Electrical Activity Between Vibrissa Sensory Areas of Cerebellum and Neocortex Is Enhanced During Free Whisking J Neurophysiol, April 1, 2002; 87(4): 2137 - 2148. [Abstract] [Full Text] [PDF]
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R. N. S. Sachdev, T. Sato, and F. F. Ebner Divergent Movement of Adjacent Whiskers J Neurophysiol, March 1, 2002; 87(3): 1440 - 1448. [Abstract] [Full Text] [PDF]
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R. Sosnik, S. Haidarliu, and E. Ahissar Temporal Frequency of Whisker Movement. I. Representations in Brain Stem and Thalamus J Neurophysiol, July 1, 2001; 86(1): 339 - 353. [Abstract] [Full Text] [PDF]
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M. Zochowski, L. B. Cohen, G. Fuhrmann, and D. Kleinfeld Distributed and Partially Separate Pools of Neurons Are Correlated with Two Different Components of the Gill-Withdrawal Reflex in Aplysia J. Neurosci., November 15, 2000; 20(22): 8485 - 8492. [Abstract] [Full Text] [PDF]
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R. N. S. Sachdev, H. Sellien, and F. F. Ebner Direct Inhibition Evoked by Whisker Stimulation in Somatic Sensory (SI) Barrel Field Cortex of the Awake Rat J Neurophysiol, September 1, 2000; 84(3): 1497 - 1504. [Abstract] [Full Text] [PDF]
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D. Kleinfeld, P. P. Mitra, F. Helmchen, and W. Denk Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex PNAS, December 22, 1998; 95(26): 15741 - 15746. [Abstract] [Full Text] [PDF]
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J. A. Hartings and D. J. Simons Thalamic Relay of Afferent Responses to 1- to 12-Hz Whisker Stimulation in the Rat J Neurophysiol, August 1, 1998; 80(2): 1016 - 1019. [Abstract] [Full Text] [PDF]
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