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Section of Oral Biology, The Ohio State University, Columbus, Ohio 43210
Halsell, Christopher B. and Susan P. Travers. Anterior and posterior oral cavity responsive neurons are differentially distributed among parabrachial subnuclei in rat. J. Neurophysiol. 78: 920-938, 1997. The responses of single parabrachial nucleus (PBN) neurons were recorded extracellularly to characterize their sensitivity to stimulation of individual gustatory receptor subpopulations (G neurons, n = 75) or mechanical stimulation of defined oral regions (M neurons, n = 54) then localized to morphologically defined PBN subdivisions. Convergence from separate oral regions onto single neurons occurred frequently for both G and M neurons, but converging influences were more potent when they arose from nearby locations confined to the anterior (AO) or posterior oral cavity (PO). A greater number of G neurons responded optimally to stimulation of AO than to PO receptor subpopulations, and these AO-best G neurons had higher spontaneous and evoked response rates but were less likely to receive convergent input than PO-best G neurons. In contrast, proportions, response rates, and convergence patterns of AO- and PO-best M neurons were more comparable. The differential sensitivity of taste receptor subpopulations was reflected in PBN responses. AO stimulation with NaCl elicited larger responses than PO stimulation; the converse was true for QHCl stimulation. Within the AO, NaCl elicited a larger response when applied to the anterior tongue than to the nasoincisor duct. Hierarchical cluster analysis of chemosensitive response profiles suggested two groups of PBN G neurons. One group was composed of neurons optimally responsive to NaCl (N cluster); the other to HCl (H cluster). Most N- and H-cluster neurons were AO-best. Although they were more heterogenous, all but one of the remaining G neurons were unique in responding best or second-best to quinine and so were designated as quinine sensitive (Q+). Twice as many Q+ neurons were PO- compared with AO-best. M neurons were scattered across PBN subdivisions, but G neurons were concentrated in two pairs of subdivisions. The central medial and ventral lateral subdivisions contained both G and M neurons but were dominated by AO-best N-cluster G neurons. The distribution of G neurons in these subdivisions appeared similar to distributions in most previous studies of PBN gustatory neurons. In contrast to earlier studies, however, the external medial and external lateral-inner subdivisions also contained G neurons, intermingled with a comparable population of M neurons. Unlike cells in the central medial and ventral lateral subnuclei, nearly every neuron in the external subnuclei was PO best, and only one was an N-cluster cell. In conclusion, the present study supports a functional distinction between sensory input from the AO and PO at the pontine level, which may represent an organizing principle throughout the gustatory neuraxis. Furthermore, two morphologically distinct pontine regions containing orosensory neurons are described.
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C. T. King, M. Garcea, D. S. Stolzenberg, and A. C. Spector Experimentally cross-wired lingual taste nerves can restore normal unconditioned gaping behavior in response to quinine stimulation Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R738 - R747. [Abstract] [Full Text] [PDF]
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J. M. Morganti, A. K. Odegard, and M. S. King The Number and Location of Fos-like Immunoreactive Neurons in the Central Gustatory System Following Electrical Stimulation of the Parabrachial Nucleus in Conscious Rats Chem Senses, July 1, 2007; 32(6): 543 - 555. [Abstract] [Full Text] [PDF]
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L. C. Geran and S. P. Travers Single Neurons in the Nucleus of the Solitary Tract Respond Selectively to Bitter Taste Stimuli J Neurophysiol, November 1, 2006; 96(5): 2513 - 2527. [Abstract] [Full Text] [PDF]
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 A. C. Spector and S. P. Travers The representation of taste quality in the Mammalian nervous system. Behav Cogn Neurosci Rev, September 1, 2005; 4(3): 143 - 191. [Abstract] [PDF]
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J. V. Verhagen, B. K. Giza, and T. R. Scott Responses to Taste Stimulation in the Ventroposteromedial Nucleus of the Thalamus in Rats J Neurophysiol, January 1, 2003; 89(1): 265 - 275. [Abstract] [Full Text] [PDF]
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S. P. Travers Quinine and citric acid elicit distinctive Fos-like immunoreactivity in the rat nucleus of the solitary tract Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1798 - R1810. [Abstract] [Full Text] [PDF]
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J.-P. Baird, J. B. Travers, and S. P. Travers Parametric analysis of gastric distension responses in the parabrachial nucleus Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1568 - R1580. [Abstract] [Full Text] [PDF]
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J.-P. Baird, S. P. Travers, and J. B. Travers Integration of gastric distension and gustatory responses in the parabrachial nucleus Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1581 - R1593. [Abstract] [Full Text] [PDF]
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B. Cerf-Ducastel, P.-F. Van de Moortele, P. MacLeod, D. Le Bihan, and A. Faurion Interaction of Gustatory and Lingual Somatosensory Perceptions at the Cortical Level in the Human: a Functional Magnetic Resonance Imaging Study Chem Senses, May 1, 2001; 26(4): 371 - 383. [Abstract] [Full Text] [PDF]
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Z. Chen, S. P. Travers, and J. B. Travers Muscimol infusions in the brain stem reticular formation reversibly block ingestion in the awake rat Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1085 - R1094. [Abstract] [Full Text] [PDF]
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 A. Blomqvist, E.-T. Zhang, and A. D. Craig Cytoarchitectonic and immunohistochemical characterization of a specific pain and temperature relay, the posterior portion of the ventral medial nucleus, in the human thalamus Brain, March 1, 2000; 123(3): 601 - 619. [Abstract] [Full Text] [PDF]
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J. B. Travers, K. Urbanek, and H. J. Grill Fos-like immunoreactivity in the brain stem following oral quinine stimulation in decerebrate rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1999; 277(2): R384 - R394. [Abstract] [Full Text] [PDF]
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 S. J. St. John and A. C. Spector Behavioral Discrimination between Quinine and KCl Is Dependent on Input from the Seventh Cranial Nerve: Implications for the Functional Roles of the Gustatory Nerves in Rats J. Neurosci., June 1, 1998; 18(11): 4353 - 4362. [Abstract] [Full Text] [PDF]
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