JN Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 78: 1222-1236, 1997;
0022-3077/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Batra, R.
Right arrow Articles by Fitzpatrick, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Batra, R.
Right arrow Articles by Fitzpatrick, D. C.

The Journal of Neurophysiology Vol. 78 No. 3 September 1997, pp. 1222-1236
Copyright ©1997 The American Physiological Society

Sensitivity to Interaural Temporal Disparities of Low- and High-Frequency Neurons in the Superior Olivary Complex. I. Heterogeneity of Responses

Ranjan Batra, Shigeyuki Kuwada, and Douglas C. Fitzpatrick

Department of Anatomy, University of Connecticut Health Center, Farmington, Connecticut 06030-3405

Batra, Ranjan, Shigeyuki Kuwada, and Douglas C. Fitzpatrick. Sensitivity to interaural temporal disparities of low- and high-frequency neurons in the superior olivary complex. I. Heterogeneity of responses. J. Neurophysiol. 78: 1222-1236, 1997. Interaural temporal disparities (ITDs) are a cue for localization of sounds along the azimuth. Listeners can detect ITDs in the fine structure of low-frequency sounds and also in the envelopes of high-frequency sounds. Sensitivity to ITDs originates in the main nuclei of the superior olivary complex (SOC), the medial and lateral superior olives (MSO and LSO, respectively). This sensitivity is believed to arise from bilateral excitation converging on neurons of the MSO and ipsilateral excitation converging with contralateral inhibition on neurons of the LSO. Here we investigate whether the sensitivity of neurons in the SOC to ITDs can be adequately explained by one of these two mechanisms. Single and multiple units (n = 124) were studied extracellularly in the SOC of unanesthetized rabbits. We found units that were sensitive to ITDs in the fine structure of low-frequency (<2 kHz) tones and also units that were sensitive to ITDs in the envelopes of sinusoidally amplitude-modulated high-frequency tones. For both categories there were "peak-type" units that discharged maximally at a particular ITD across frequencies or modulation frequencies. These units were consistent with an MSO-type mechanism. There were also "trough-type" units that discharged minimally at a particular ITD. These units were consistent with an LSO-type mechanism. There was a general trend for peak-type units to be located in the vicinity of the MSO and for trough-type units to be located in the vicinity of the LSO. Units of both types appeared to encode ITDs within the estimated free-field range of the rabbit (±300 µs). Many units had varying degrees of irregularities in their responses, which manifested themselves in one of two ways. First, for some units there was no ITD at which the response was consistently maximal or minimal across frequencies. Instead there was an ITD at which the unit consistently responded at some intermediate level. Second, a unit could display considerable jitter from frequency to frequency in the ITD at which it responded maximally or minimally. Units with irregular responses had properties that were continuous with those of other units. They therefore appeared to be variants of peak- and trough-type units. The irregular responses could be modeled by assuming additional phase-locked inputs to a neuron in the MSO or LSO. The function of irregularities may be to shift the ITD sensitivity of a neuron without requiring changes in the anatomic delays of its inputs.




This article has been cited by other articles:


Home page
 Cereb CortexHome page
J. Tillein, P. Hubka, E. Syed, R. Hartmann, A.K. Engel, and A. Kral
Cortical Representation of Interaural Time Difference in Congenital Deafness
Cereb Cortex, November 11, 2009; (2009) bhp222v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. E. Carr, D. Soares, J. Smolders, and J. Z. Simon
Detection of Interaural Time Differences in the Alligator
J. Neurosci., June 24, 2009; 29(25): 7978 - 7990.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. H. Scott, B. J. Malone, and M. N. Semple
Representation of Dynamic Interaural Phase Difference in Auditory Cortex of Awake Rhesus Macaques
J Neurophysiol, April 1, 2009; 101(4): 1781 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
M. Ahissar, M. Nahum, I. Nelken, and S. Hochstein
Reverse hierarchies and sensory learning
Phil Trans R Soc B, February 12, 2009; 364(1515): 285 - 299.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. P. Agapiou and D. McAlpine
Low-Frequency Envelope Sensitivity Produces Asymmetric Binaural Tuning Curves
J Neurophysiol, October 1, 2008; 100(4): 2381 - 2396.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Pecka, A. Brand, O. Behrend, and B. Grothe
Interaural Time Difference Processing in the Mammalian Medial Superior Olive: The Role of Glycinergic Inhibition
J. Neurosci., July 2, 2008; 28(27): 6914 - 6925.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. M. Caspary, L. Ling, J. G. Turner, and L. F. Hughes
Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system
J. Exp. Biol., June 1, 2008; 211(11): 1781 - 1791.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Siveke, C. Leibold, and B. Grothe
Spectral Composition of Concurrent Noise Affects Neuronal Sensitivity to Interaural Time Differences of Tones in the Dorsal Nucleus of the Lateral Lemniscus
J Neurophysiol, November 1, 2007; 98(5): 2705 - 2715.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. V. Seshagiri and B. Delgutte
Response Properties of Neighboring Neurons in the Auditory Midbrain for Pure-Tone Stimulation: A Tetrode Study
J Neurophysiol, October 1, 2007; 98(4): 2058 - 2073.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. A. Davis, O. Lomakin, and M. J. Pesavento
Response Properties of Single Units in the Dorsal Nucleus of the Lateral Lemniscus of Decerebrate Cats
J Neurophysiol, September 1, 2007; 98(3): 1475 - 1488.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Siveke, M. Pecka, A. H. Seidl, S. Baudoux, and B. Grothe
Binaural Response Properties of Low-Frequency Neurons in the Gerbil Dorsal Nucleus of the Lateral Lemniscus
J Neurophysiol, September 1, 2006; 96(3): 1425 - 1440.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Kuwada, D. C. Fitzpatrick, R. Batra, and E.-M. Ostapoff
Sensitivity to Interaural Time Differences in the Dorsal Nucleus of the Lateral Lemniscus of the Unanesthetized Rabbit: Comparison With Other Structures
J Neurophysiol, March 1, 2006; 95(3): 1309 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. X. Joris, B. van de Sande, A. Recio-Spinoso, and M. van der Heijden
Auditory Midbrain and Nerve Responses to Sinusoidal Variations in Interaural Correlation
J. Neurosci., January 4, 2006; 26(1): 279 - 289.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. J. Tollin and T. C. T. Yin
Interaural Phase and Level Difference Sensitivity in Low-Frequency Neurons in the Lateral Superior Olive
J. Neurosci., November 16, 2005; 25(46): 10648 - 10657.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. R. D'Angelo, S. J. Sterbing, E.-M. Ostapoff, and S. Kuwada
Role of GABAergic Inhibition in the Coding of Interaural Time Differences of Low-Frequency Sounds in the Inferior Colliculus
J Neurophysiol, June 1, 2005; 93(6): 3390 - 3400.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. J. Griffin, L. R. Bernstein, N. J. Ingham, and D. McAlpine
Neural Sensitivity to Interaural Envelope Delays in the Inferior Colliculus of the Guinea Pig
J Neurophysiol, June 1, 2005; 93(6): 3463 - 3478.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. H. G. Louage, M. van der Heijden, and P. X. Joris
Enhanced Temporal Response Properties of Anteroventral Cochlear Nucleus Neurons to Broadband Noise
J. Neurosci., February 9, 2005; 25(6): 1560 - 1570.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. X. JORIS, C. E. SCHREINER, and A. REES
Neural Processing of Amplitude-Modulated Sounds
Physiol Rev, April 1, 2004; 84(2): 541 - 577.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. L. Oliver, G. E. Beckius, D. C. Bishop, W. C. Loftus, and R. Batra
Topography of Interaural Temporal Disparity Coding in Projections of Medial Superior Olive to Inferior Colliculus
J. Neurosci., August 13, 2003; 23(19): 7438 - 7449.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
D. J. Tollin
The Lateral Superior Olive: A Functional Role in Sound Source Localization
Neuroscientist, April 1, 2003; 9(2): 127 - 143.
[Abstract] [PDF]

Home page
 J. Neurophysiol.Home page
R. Ramachandran and B. J. May
Functional Segregation of ITD Sensitivity in the Inferior Colliculus of Decerebrate Cats
J Neurophysiol, November 1, 2002; 88(5): 2251 - 2261.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. P. Walton, H. Simon, and R. D. Frisina
Age-Related Alterations in the Neural Coding of Envelope Periodicities
J Neurophysiol, August 1, 2002; 88(2): 565 - 578.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Batra and D. C. Fitzpatrick
Processing of Interaural Temporal Disparities in the Medial Division of the Ventral Nucleus of the Lateral Lemniscus
J Neurophysiol, August 1, 2002; 88(2): 666 - 675.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
O. Behrend, A. Brand, C. Kapfer, and B. Grothe
Auditory Response Properties in the Superior Paraolivary Nucleus of the Gerbil
J Neurophysiol, June 1, 2002; 87(6): 2915 - 2928.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. J. Tollin and T. C. T. Yin
The Coding of Spatial Location by Single Units in the Lateral Superior Olive of the Cat. I. Spatial Receptive Fields in Azimuth
J. Neurosci., February 15, 2002; 22(4): 1454 - 1467.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. J. Tollin and T. C. T. Yin
The Coding of Spatial Location by Single Units in the Lateral Superior Olive of the Cat. II. The Determinants of Spatial Receptive Fields in Azimuth
J. Neurosci., February 15, 2002; 22(4): 1468 - 1479.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Grothe, E. Covey, and J. H. Casseday
Medial Superior Olive of the Big Brown Bat: Neuronal Responses to Pure Tones, Amplitude Modulations, and Pulse Trains
J Neurophysiol, November 1, 2001; 86(5): 2219 - 2230.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. R. Palmer, D. Jiang, and D. McAlpine
Neural Responses in the Inferior Colliculus to Binaural Masking Level Differences Created by Inverting the Noise in One Ear
J Neurophysiol, August 1, 2000; 84(2): 844 - 852.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. C. Fitzpatrick, S. Kuwada, and R. Batra
Neural Sensitivity to Interaural Time Differences: Beyond the Jeffress Model
J. Neurosci., February 15, 2000; 20(4): 1605 - 1615.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Batra and D. C. Fitzpatrick
Discharge Patterns of Neurons in the Ventral Nucleus of the Lateral Lemniscus of the Unanesthetized Rabbit
J Neurophysiol, September 1, 1999; 82(3): 1097 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. A. Davis, R. Ramachandran, and B. J. May
Single-Unit Responses in the Inferior Colliculus of Decerebrate Cats II. Sensitivity to Interaural Level Differences
J Neurophysiol, July 1, 1999; 82(1): 164 - 175.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. E. Beckius, R. Batra, and D. L. Oliver
Axons from Anteroventral Cochlear Nucleus that Terminate in Medial Superior Olive of Cat: Observations Related to Delay Lines
J. Neurosci., April 15, 1999; 19(8): 3146 - 3161.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Kuwada and R. Batra
Coding of Sound Envelopes by Inhibitory Rebound in Neurons of the Superior Olivary Complex in the Unanesthetized Rabbit
J. Neurosci., March 15, 1999; 19(6): 2273 - 2287.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Grothe and T. J. Park
Sensitivity to Interaural Time Differences in the Medial Superior Olive of a Small Mammal, the Mexican Free-Tailed Bat
J. Neurosci., August 15, 1998; 18(16): 6608 - 6622.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. X. Joris and T. C. T. Yin
Envelope Coding in the Lateral Superior Olive. III. Comparison With Afferent Pathways
J Neurophysiol, January 1, 1998; 79(1): 253 - 269.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Batra, S. Kuwada, and D. C. Fitzpatrick
Sensitivity to Interaural Temporal Disparities of Low- and High-Frequency Neurons in the Superior Olivary Complex. II. Coincidence Detection
J Neurophysiol, September 1, 1997; 78(3): 1237 - 1247.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online