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RAPID COMMUNICATION
Laboratory of Neurophysiology, Biomedical Research Institute, Kaunas Medical Academy, 3000 Kaunas, Lithuania; and Department of Medical Physiology, The Panum Institute, Copenhagen University, DK-2200 Copenhagen N, Denmark
Svirskis, Gytis and Jørn Hounsgaard. Depolarization-induced facilitation of a plateau-generating current in ventral horn neurons in the turtle spinal cord. J. Neurophysiol. 78: 1740-1742, 1997. Plasticity at the neuronal level commonly involves use-dependent changes in strength of particular synaptic pathways or regulation of postsynaptic properties by modulatory transmitters. Here we analyze a novel form of short-term plasticity mediated by use- dependent facilitation of postsynaptic responsiveness. Using current- and voltage-clamp recordings, we found that all spinal ventral horn neurons able to generate plateau potentials showed depolarization-induced facilitation of the underlying inward current. Facilitation was noticeable when the neurons were depolarized to more than 
50 mV at intervals <4 s. When stimulation with fast triangular voltage ramps was used, the inward current activated at a less depolarized potential during the second ramp. The inward current and facilitation was eliminated by nifedipine, a selective antagonist of L-type calcium channels. Depolarization-induced facilitation of low-voltage-activated L-type calcium channels is suggested to be the underlying mechanism. It is noted that facilitation occurs on a time scale compatible with a role in phasic motor activity.
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R. H. Lee and C. J. Heckman Bistability in Spinal Motoneurons In Vivo: Systematic Variations in Persistent Inward Currents J Neurophysiol, August 1, 1998; 80(2): 583 - 593. [Abstract] [Full Text] [PDF]
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G. Svirskis and J. Hounsgaard Transmitter Regulation of Plateau Properties in Turtle Motoneurons J Neurophysiol, January 1, 1998; 79(1): 45 - 50. [Abstract] [Full Text] [PDF]
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