JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 78: 2280-2286, 1997;
0022-3077/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, S. J.
Right arrow Articles by Prince, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, S. J.
Right arrow Articles by Prince, D. A.

The Journal of Neurophysiology Vol. 78 No. 5 November 1997, pp. 2280-2286
Copyright ©1997 The American Physiological Society

GABAA Receptor-Mediated Clminus Currents in Rat Thalamic Reticular and Relay Neurons

Shuanglin J. Zhang, John R. Huguenard, and David A. Prince

Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305

Zhang, Shuanglin J., John R. Huguenard, and David A. Prince. GABAA receptor-mediated Cl- currents in rat thalamic reticular and relay neurons. J. Neurophysiol. 78: 2280-2286, 1997. Spontaneous and evoked inhibitory postsynaptic currents (sIPSCs and eIPSCs) and responses to exogenously applied gamma -aminobutyric acid (GABA), mediated by GABA type A (GABAA) receptors, were recorded in inhibitory neurons of nucleus reticularis thalami (nRt) and their target relay cells in ventrobasal (VB) nuclei by using patch clamp techniques in rat thalamic slices. The decay of sIPSCs in both nRt and VB neurons was best fitted with two exponential components. The decay time constants of sIPSCs in nRt neurons were much slower (tau 1 = 38 ms; tau 2 = 186 ms) than those previously reported in a variety of preparations and two to three times slower than those in VB neurons (tau 1 = 17 ms; tau 2 = 39 ms). GABAA receptor-mediated Cl- currents directly evoked by local GABA application also had a much slower decay time constant in nRt (225 ms) than in VB neurons (115 ms). Slow decay of GABA responses enhances the efficacy of recurrent intranuclear inhibition in nRt. The results suggest a functional diversity of GABAA receptors that may relate to the known heterogeneity of GABAA receptor subunits in these two thalamic nuclei.




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
F. Jia, M. Yue, D. Chandra, G. E. Homanics, P. A. Goldstein, and N. L. Harrison
Isoflurane Is a Potent Modulator of Extrasynaptic GABAA Receptors in the Thalamus
J. Pharmacol. Exp. Ther., March 1, 2008; 324(3): 1127 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. R. Peden, C. M. Petitjean, M. B. Herd, M. S. Durakoglugil, T. W. Rosahl, K. Wafford, G. E. Homanics, D. Belelli, J.-M. Fritschy, and J. J. Lambert
Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones
J. Physiol., February 15, 2008; 586(4): 965 - 987.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Jia, M. Yue, D. Chandra, A. Keramidas, P. A. Goldstein, G. E. Homanics, and N. L. Harrison
Taurine Is a Potent Activator of Extrasynaptic GABAA Receptors in the Thalamus
J. Neurosci., January 2, 2008; 28(1): 106 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Rajasekaran, J. Kapur, and E. H. Bertram
Alterations in GABAA Receptor Mediated Inhibition in Adjacent Dorsal Midline Thalamic Nuclei in a Rat Model of Chronic Limbic Epilepsy
J Neurophysiol, November 1, 2007; 98(5): 2501 - 2508.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. M. Schofield and J. R. Huguenard
GABA Affinity Shapes IPSCs in Thalamic Nuclei
J. Neurosci., July 25, 2007; 27(30): 7954 - 7962.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X.-B. Liu, J. Coble, G. van Luijtelaar, and E. G. Jones
Reticular nucleus-specific changes in {alpha}3 subunit protein at GABA synapses in genetically epilepsy-prone rats
PNAS, July 24, 2007; 104(30): 12512 - 12517.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Bessaih, L. Bourgeais, C. I. Badiu, D. A. Carter, T. I. Toth, D. Ruano, B. Lambolez, V. Crunelli, and N. Leresche
Nucleus-Specific Abnormalities of GABAergic Synaptic Transmission in a Genetic Model of Absence Seizures
J Neurophysiol, December 1, 2006; 96(6): 3074 - 3081.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y.-W. Lam, C. S. Nelson, and S. M. Sherman
Mapping of the Functional Interconnections Between Thalamic Reticular Neurons Using Photostimulation
J Neurophysiol, November 1, 2006; 96(5): 2593 - 2600.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. M. Huntsman and J. R. Huguenard
Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor {beta}1 subunit
J. Physiol., April 15, 2006; 572(2): 459 - 475.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. Jia, L. Pignataro, C. M. Schofield, M. Yue, N. L. Harrison, and P. A. Goldstein
An Extrasynaptic GABAA Receptor Mediates Tonic Inhibition in Thalamic VB Neurons
J Neurophysiol, December 1, 2005; 94(6): 4491 - 4501.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. D. Traub, D. Contreras, M. O. Cunningham, H. Murray, F. E. N. LeBeau, A. Roopun, A. Bibbig, W. B. Wilent, M. J. Higley, and M. A. Whittington
Single-Column Thalamocortical Network Model Exhibiting Gamma Oscillations, Sleep Spindles, and Epileptogenic Bursts
J Neurophysiol, April 1, 2005; 93(4): 2194 - 2232.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Fuentealba, I. Timofeev, and M. Steriade
From The Cover: Prolonged hyperpolarizing potentials precede spindle oscillations in the thalamic reticular nucleus
PNAS, June 29, 2004; 101(26): 9816 - 9821.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
A. Rodriguez, J. Whitson, and R. Granger
Derivation and Analysis of Basic Computational Operations of Thalamocortical Circuits
J. Cogn. Neurosci., June 1, 2004; 16(5): 856 - 877.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Zhang and E. G. Jones
Corticothalamic Inhibition in the Thalamic Reticular Nucleus
J Neurophysiol, February 1, 2004; 91(2): 759 - 766.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. A. Hartings, S. Temereanca, and D. J. Simons
Processing of Periodic Whisker Deflections By Neurons in the Ventroposterior Medial and Thalamic Reticular Nuclei
J Neurophysiol, November 1, 2003; 90(5): 3087 - 3094.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Q.-Q. Sun, S. C. Baraban, D. A. Prince, and J. R. Huguenard
Target-Specific Neuropeptide Y-Ergic Synaptic Inhibition and Its Network Consequences within the Mammalian Thalamus
J. Neurosci., October 22, 2003; 23(29): 9639 - 9649.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. DESTEXHE and T. J. SEJNOWSKI
Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations
Physiol Rev, October 1, 2003; 83(4): 1401 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. A. Hartings, S. Temereanca, and D. J. Simons
State-Dependent Processing of Sensory Stimuli by Thalamic Reticular Neurons
J. Neurosci., June 15, 2003; 23(12): 5264 - 5271.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Shu and D. A. McCormick
Inhibitory Interactions Between Ferret Thalamic Reticular Neurons
J Neurophysiol, May 1, 2002; 87(5): 2571 - 2576.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. J. Slaght, N. Leresche, J.-M. Deniau, V. Crunelli, and S. Charpier
Activity of Thalamic Reticular Neurons during Spontaneous Genetically Determined Spike and Wave Discharges
J. Neurosci., March 15, 2002; 22(6): 2323 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. E. Landisman, M. A. Long, M. Beierlein, M. R. Deans, D. L. Paul, and B. W. Connors
Electrical Synapses in the Thalamic Reticular Nucleus
J. Neurosci., February 1, 2002; 22(3): 1002 - 1009.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. D. Traub, N. Kopell, A. Bibbig, E. H. Buhl, F. E. N. LeBeau, and M. A. Whittington
Gap Junctions between Interneuron Dendrites Can Enhance Synchrony of Gamma Oscillations in Distributed Networks
J. Neurosci., December 1, 2001; 21(23): 9478 - 9486.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. H. Browne, J. Kang, G. Akk, L. W. Chiang, H. Schulman, J. R. Huguenard, and D. A. Prince
Kinetic and Pharmacological Properties of GABAA Receptors in Single Thalamic Neurons and GABAA Subunit Expression
J Neurophysiol, November 1, 2001; 86(5): 2312 - 2322.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. S. Sohal, M. M. Huntsman, and J. R. Huguenard
Reciprocal Inhibitory Connections Regulate the Spatiotemporal Properties of Intrathalamic Oscillations
J. Neurosci., March 1, 2000; 20(5): 1735 - 1745.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. M. Huntsman and J. R. Huguenard
Nucleus-Specific Differences in GABAA-Receptor-Mediated Inhibition Are Enhanced During Thalamic Development
J Neurophysiol, January 1, 2000; 83(1): 350 - 358.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. M. Huntsman, D. M. Porcello, G. E. Homanics, T. M. DeLorey, and J. R. Huguenard
Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus
Science, January 22, 1999; 283(5401): 541 - 543.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online