| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
Williams, John H. and Julie A. Kauer. Properties of carbachol-induced oscillatory activity in rat hippocampus. J. Neurophysiol. 78: 2631-2640, 1997. The recent resurgence of interest in carbachol oscillations as an in vitro model of theta rhythm in the hippocampus prompted us to evaluate the circuit mechanisms involved. In extracellular recordings, a regularly spaced bursting pattern of field potentials was observed in both CA3 and CA1 subfields in the presence of carbachol. Removal of the CA3 region abolished oscillatory activity observed in CA1, suggesting that the oscillatory generator is located in CA3. An 
-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, 6,7-dinitroquinoxaline-2,3-dione (DNQX), blocked carbachol oscillations, indicating that AMPA receptor-mediated synaptic currents are necessary for the population oscillation. Moreover, the spread of oscillatory activity into CA1 required intact N-methyl-D-aspartate receptors. These data are more consistent with epileptiform bursting than with theta rhythm described in vivo. In the presence of carbachol, individual CA3 pyramidal cells exhibited a slow, rhythmic intrinsic oscillation that was not blocked by DNQX and that was enhanced by membrane hyperpolarization. We hypothesize that this slower oscillation is the fundamental oscillator that participates in triggering the population oscillation by exciting multiple synaptically connected CA3 neurons. 
-aminobutyric acid-A (GABAA) receptors are not necessary for carbachol to elicit synchronous CA3 field events but are essential to the bursting pattern observed. Neither GABAB nor metabotropic glutamate receptors appear to be necessary for carbachol oscillations. However, both nicotinic and M1 and M3 muscarinic cholinergic receptors contribute to the generation of this activity. These results establish the local circuit elements and neurotransmitter receptors that contribute to carbachol-induced oscillations and indicate that carbachol-induced oscillations are fundamentally distinct from theta rhythm in vivo.
This article has been cited by other articles:
|
|
 |
|
  R. N. Leao, H. M. Tan, and A. Fisahn Kv7/KCNQ Channels Control Action Potential Phasing of Pyramidal Neurons during Hippocampal Gamma Oscillations In Vitro J. Neurosci., October 21, 2009; 29(42): 13353 - 13364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Manseau, R. Goutagny, M. Danik, and S. Williams The Hippocamposeptal Pathway Generates Rhythmic Firing of GABAergic Neurons in the Medial Septum and Diagonal Bands: An Investigation Using a Complete Septohippocampal Preparation In Vitro J. Neurosci., April 9, 2008; 28(15): 4096 - 4107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weiergraber, M. Henry, K. Radhakrishnan, J. Hescheler, and T. Schneider Hippocampal Seizure Resistance and Reduced Neuronal Excitotoxicity in Mice Lacking the Cav2.3 E/R-Type Voltage-Gated Calcium Channel J Neurophysiol, May 1, 2007; 97(5): 3660 - 3669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Orban, T. Kiss, and P. Erdi Intrinsic and Synaptic Mechanisms Determining the Timing of Neuron Population Activity During Hippocampal Theta Oscillation J Neurophysiol, December 1, 2006; 96(6): 2889 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Garcia-Osta, P. Tsokas, G. Pollonini, E. M. Landau, R. Blitzer, and C. M. Alberini MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation. J. Neurosci., July 26, 2006; 26(30): 7919 - 7932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Fitch, R. N. Sahr, B. J. Eastwood, F. C. Zhou, and C. R. Yang Dopamine D1/5 Receptor Modulation of Firing Rate and Bidirectional Theta Burst Firing in Medial Septal/Vertical Limb of Diagonal Band Neurons In Vivo J Neurophysiol, May 1, 2006; 95(5): 2808 - 2820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Scheiderer, E. McCutchen, E. E. Thacker, K. Kolasa, M. K. Ward, D. Parsons, L. E. Harrell, L. E. Dobrunz, and L. L. McMahon Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses. J. Neurosci., April 5, 2006; 26(14): 3745 - 3756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shin, D. Kim, R. Bianchi, R. K. S. Wong, and H.-S. Shin Genetic dissection of theta rhythm heterogeneity in mice PNAS, December 13, 2005; 102(50): 18165 - 18170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Reich, M. A. Karson, S. V. Karnup, L. M. Jones, and B. E. Alger Regulation of IPSP Theta Rhythm by Muscarinic Receptors and Endocannabinoids in Hippocampus J Neurophysiol, December 1, 2005; 94(6): 4290 - 4299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Rotstein, D. D. Pervouchine, C. D. Acker, M. J. Gillies, J. A. White, E. H. Buhl, M. A. Whittington, and N. Kopell Slow and Fast Inhibition and an H-Current Interact to Create a Theta Rhythm in a Model of CA1 Interneuron Network J Neurophysiol, August 1, 2005; 94(2): 1509 - 1518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Cobb and C. H. Davies Cholinergic modulation of hippocampal cells and circuits J. Physiol., January 1, 2005; 562(1): 81 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kubota, L. L. Colgin, M. Casale, F. A. Brucher, and G. Lynch Endogenous Waves in Hippocampal Slices J Neurophysiol, January 1, 2003; 89(1): 81 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M J Gillies, R D Traub, F E N LeBeau, C H Davies, T Gloveli, E H Buhl, and M A Whittington A model of atropine-resistant theta oscillations in rat hippocampal area CA1 J. Physiol., September 15, 2002; 543(3): 779 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wu, H. Shen, W. P. Luk, and L. Zhang A fundamental oscillatory state of isolated rodent hippocampus J. Physiol., April 15, 2002; 540(2): 509 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fischer, L. Wittner, T. F Freund, and B. H Gahwiler Simultaneous activation of gamma and theta network oscillations in rat hippocampal slice cultures J. Physiol., March 15, 2002; 539(3): 857 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-J. Wang Pacemaker Neurons for the Theta Rhythm and Their Synchronization in the Septohippocampal Reciprocal Loop J Neurophysiol, February 1, 2002; 87(2): 889 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D'Antuono, H. Kawasaki, C. Palmieri, and M. Avoli Network and Intrinsic Contributions to Carbachol-Induced Oscillations in the Rat Subiculum J Neurophysiol, September 1, 2001; 86(3): 1164 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Stenkamp, J. M. Palva, M. Uusisaari, S. Schuchmann, D. Schmitz, U. Heinemann, and K. Kaila Enhanced Temporal Stability of Cholinergic Hippocampal Gamma Oscillations Following Respiratory Alkalosis In Vitro J Neurophysiol, May 1, 2001; 85(5): 2063 - 2069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-K. Sun, W.-Q. Zhao, T. J. Nelson, and D. L. Alkon Theta Rhythm of Hippocampal CA1 Neuron Activity: Gating by GABAergic Synaptic Depolarization J Neurophysiol, January 1, 2001; 85(1): 269 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shimono, F. Brucher, R. Granger, G. Lynch, and M. Taketani Origins and Distribution of Cholinergically Induced beta Rhythms in Hippocampal Slices J. Neurosci., November 15, 2000; 20(22): 8462 - 8473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Sanchez, C. Wang, G. Gardner, L. Orlando, D. L. Tauck, P. A. Rosenberg, E. Aizenman, and F. E. Jensen Novel Role for the NMDA Receptor Redox Modulatory Site in the Pathophysiology of Seizures J. Neurosci., March 15, 2000; 20(6): 2409 - 2417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Hochman and P. A. Schwartzkroin Chloride-Cotransport Blockade Desynchronizes Neuronal Discharge in the "Epileptic" Hippocampal Slice J Neurophysiol, January 1, 2000; 83(1): 406 - 417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. van der Linden, F. Panzica, and M. de Curtis Carbachol Induces Fast Oscillations in the Medial but not in the Lateral Entorhinal Cortex of the Isolated Guinea Pig Brain J Neurophysiol, November 1, 1999; 82(5): 2441 - 2450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Chapman and J.-C. Lacaille Cholinergic Induction of Theta-Frequency Oscillations in Hippocampal Inhibitory Interneurons and Pacing of Pyramidal Cell Firing J. Neurosci., October 1, 1999; 19(19): 8637 - 8645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fischer, B. H Gahwiler, and S. M Thompson Activation of intrinsic hippocampal theta oscillations by acetylcholine in rat septo-hippocampal cocultures J. Physiol., September 1, 1999; 519(2): 405 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kocsis, A. Bragin, and G. Buzsaki Interdependence of Multiple Theta Generators in the Hippocampus: a Partial Coherence Analysis J. Neurosci., July 15, 1999; 19(14): 6200 - 6212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Avignone and E. Cherubini Muscarinic receptor modulation of GABA-mediated giant depolarizing potentials in the neonatal rat hippocampus J. Physiol., July 1, 1999; 518(1): 97 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. McMahon, J. H. Williams, and J. A. Kauer Functionally Distinct Groups of Interneurons Identified During Rhythmic Carbachol Oscillations in Hippocampus In Vitro J. Neurosci., August 1, 1998; 18(15): 5640 - 5651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fischer, L. Wittner, T. F Freund, and B. H Gahwiler Simultaneous activation of gamma and theta network oscillations in rat hippocampal slice cultures J. Physiol., March 15, 2002; 539(3): 857 - 868. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
