JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 78: 3450-3452, 1997;
0022-3077/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cleland, T. A.
Right arrow Articles by Selverston, A. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cleland, T. A.
Right arrow Articles by Selverston, A. I.

The Journal of Neurophysiology Vol. 78 No. 6 December 1997, pp. 3450-3452
Copyright ©1997 The American Physiological Society

Dopaminergic Modulation of Inhibitory Glutamate Receptors in the Lobster Stomatogastric Ganglion

Thomas A. Cleland and Allen I. Selverston

Department of Biology, University of California, San Diego, La Jolla, California 92093-0357

Cleland, Thomas A. and Allen I. Selverston. Dopaminergic modulation of inhibitory glutamate receptors in the lobster stomatogastric ganglion. J. Neurophysiol. 78: 3450-3452, 1997. The intrinsic rhythmicity of the spiny lobster stomatogastric ganglion (STG) is strongly influenced by the strengths of the graded synapses between identified cells within the neural network. These synaptic strengths can be powerfully influenced by chemical neuromodulators such as dopamine and serotonin. Most of the intraganglionic chemical synapses in the STG are mediated by postsynaptic inhibitory glutamate receptors (IGluRs). To determine whether or not direct effects on these IGluRs contribute to the modulation of synaptic strength, unidentified STG neurons were extracted into primary culture and the effects of these aminergic neuromodulators on the glutamate-evoked membrane current were assessed. Dopamine (100 µM) reliably and significantly reduced the whole cell slope conductance of all IGluRs tested. Serotonin (20 µM) never affected the IGlu response, although it clearly altered other cellular membrane properties. Although all identified STG neurons may not conform to these observations, the data reveal a specific dopamine-activated modulatory pathway within cultured neurons that reduces IGluR slope conductance. The relationship between IGluR modulation and net synaptic modulation in situ contributes to an emerging model in which synaptic strengths can be multiply modulated at different functional sites, yielding a complex, distributed, and state-dependent regulatory structure.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
J. D. Hunter and J. G. Milton
Synaptic Heterogeneity and Stimulus-Induced Modulation of Depression in Central Synapses
J. Neurosci., August 1, 2001; 21(15): 5781 - 5793.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. A. Cleland and A. I. Selverston
Inhibitory Glutamate Receptor Channels in Cultured Lobster Stomatogastric Neurons
J Neurophysiol, June 1, 1998; 79(6): 3189 - 3196.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Ayali, B. R. Johnson, and R. M. Harris-Warrick
Dopamine Modulates Graded and Spike-Evoked Synaptic Inhibition Independently at Single Synapses in Pyloric Network of Lobster
J Neurophysiol, April 1, 1998; 79(4): 2063 - 2069.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online