JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 79: 322-333, 1998;
0022-3077/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hasegawa, R.
Right arrow Articles by Kubota, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hasegawa, R.
Right arrow Articles by Kubota, K.

The Journal of Neurophysiology Vol. 79 No. 1 January 1998, pp. 322-333
Copyright ©1998 The American Physiological Society

Monkey Prefrontal Neuronal Activity Coding the Forthcoming Saccade in an Oculomotor Delayed Matching-to-Sample Task

Ryohei Hasegawa, Toshiyuki Sawaguchi, and Kisou Kubota

Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto University, Kanrin, Inuyama, Aichi 484, Japan

Hasegawa, Ryohei, Toshiyuki Sawaguchi, and Kisou Kubota. Monkey prefrontal neuronal activity coding the forthcoming saccade in an oculomotor delayed matching-to-sample task. J. Neurophysiol. 79: 322-333, 1998. To determine the role of the dorsolateral prefrontal cortex (PFC) in the selection of memory-guided saccadic eye movements, we recorded the activities of PFC neurons while macaque monkeys performed an oculomotor delayed matching-to-sample task. The task was designed to dissociate motor factors from visual factors in the selection and retention of the direction of the forthcoming saccade during delay periods after the visual cue but before the GO signal was presented. While the monkey fixated on a central fixation spot (FX period, 1 s), a sample cue (1 of 4 geometric figures) and a matching cue composed of two geometric figures were presented in succession (SC and MC periods, respectively, 0.5 s) with a brief delay (D1 period, 1 or 1.5 s). After another delay (D2 period, 1.5 s), the monkey made a saccade (GO period, <0.5 s) toward one of four locations (the goal) that had been indicated by the combination of the sample and matching cues in the MC period. We recorded the activities of 224 neurons in the periprincipal sulcal area of 3 hemispheres of 2 monkeys. Sixty-five neurons (29%) showed a significant increase in activity during the D2 period. Some of these also responded during other phases of the task (SC period, n = 32; D1, 22; MC, 53; GO, 47). Some of the activity during the D2(52/65, 80%) and GO (40/47, 85%) periods was associated with the direction of the forthcoming saccade ("direction selective"). Although most MC-period activities of D2 neurons were direction selective (38/53, 73%), a fraction of them (14/38) was also affected by both saccade direction and matching cue pattern. To compare quantitatively the contribution of motor (saccade direction) and visual (matching-cue pattern) factors to the activity of D2 neurons, we calculated directional and visual dependency indices (DDI and VDI) for each of the three periods (MC, D2, and GO). In both the D2 and GO periods, D2 neurons with high DDI values and low VDI values predominated. In the MC period, however, there was no significant difference between the distributions of DDI and VDI values. These findings suggest that PFC neurons store the direction of memory-guided saccades during a delay period before eye movement and that the same neurons may be involved in the decision-making process that underlies the selection of the saccade direction during the MC period.




This article has been cited by other articles:


Home page
 Cereb CortexHome page
S. Tsujimoto, A. Genovesio, and S. P. Wise
Transient Neuronal Correlations Underlying Goal Selection and Maintenance in Prefrontal Cortex
Cereb Cortex, March 20, 2008; (2008) bhn033v1.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
K. Watanabe and S. Funahashi
Prefrontal Delay-Period Activity Reflects the Decision Process of a Saccade Direction during a Free-Choice ODR Task
Cereb Cortex, September 1, 2007; 17(suppl_1): i88 - i100.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
K.-i. Amemori and T. Sawaguchi
Contrasting Effects of Reward Expectation on Sensory and Motor Memories in Primate Prefrontal Neurons
Cereb Cortex, July 1, 2006; 16(7): 1002 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Hoshi and J. Tanji
Differential Involvement of Neurons in the Dorsal and Ventral Premotor Cortex During Processing of Visual Signals for Action Planning
J Neurophysiol, June 1, 2006; 95(6): 3596 - 3616.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Inoue and A. Mikami
Prefrontal Activity During Serial Probe Reproduction Task: Encoding, Mnemonic, and Retrieval Processes
J Neurophysiol, February 1, 2006; 95(2): 1008 - 1041.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
N. Saito, H. Mushiake, K. Sakamoto, Y. Itoyama, and J. Tanji
Representation of Immediate and Final Behavioral Goals in the Monkey Prefrontal Cortex during an Instructed Delay Period
Cereb Cortex, October 1, 2005; 15(10): 1535 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Tsujimoto and T. Sawaguchi
Context-dependent Representation of Response-outcome in Monkey Prefrontal Neurons
Cereb Cortex, July 1, 2005; 15(7): 888 - 898.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
E. Volle, J.B. Pochon, S. Lehericy, B. Pillon, B. Dubois, and R. Levy
Specific Cerebral Networks for Maintenance and Response Organization within Working Memory as Evidenced by the 'Double Delay/Double Response' Paradigm
Cereb Cortex, July 1, 2005; 15(7): 1064 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Tsujimoto and T. Sawaguchi
Neuronal Activity Representing Temporal Prediction of Reward in the Primate Prefrontal Cortex
J Neurophysiol, June 1, 2005; 93(6): 3687 - 3692.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. P. Hasegawa, A. M. Blitz, and M. E. Goldberg
Neurons in Monkey Prefrontal Cortex Whose Activity Tracks the Progress of a Three-Step Self-Ordered Task
J Neurophysiol, September 1, 2004; 92(3): 1524 - 1535.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Watanabe and S. Funahashi
Neuronal Activity Throughout the Primate Mediodorsal Nucleus of the Thalamus During Oculomotor Delayed-Responses. II. Activity Encoding Visual Versus Motor Signal
J Neurophysiol, September 1, 2004; 92(3): 1756 - 1769.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Hoshi and J. Tanji
Area-Selective Neuronal Activity in the Dorsolateral Prefrontal Cortex for Information Retrieval and Action Planning
J Neurophysiol, June 1, 2004; 91(6): 2707 - 2722.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Fukushima, I. Hasegawa, and Y. Miyashita
Prefrontal Neuronal Activity Encodes Spatial Target Representations Sequentially Updated After Nonspatial Target-Shift Cues
J Neurophysiol, March 1, 2004; 91(3): 1367 - 1380.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Takeda and S. Funahashi
Prefrontal Task-Related Activity Representing Visual Cue Location or Saccade Direction in Spatial Working Memory Tasks
J Neurophysiol, January 1, 2002; 87(1): 567 - 588.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. D. Horwitz and W. T. Newsome
Target Selection for Saccadic Eye Movements: Direction-Selective Visual Responses in the Superior Colliculus
J Neurophysiol, November 1, 2001; 86(5): 2527 - 2542.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. N. Shadlen and W. T. Newsome
Neural Basis of a Perceptual Decision in the Parietal Cortex (Area LIP) of the Rhesus Monkey
J Neurophysiol, October 1, 2001; 86(4): 1916 - 1936.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. L. LeVasseur, J. R. Flanagan, R. J. Riopelle, and D. P. Munoz
Control of volitional and reflexive saccades in Tourette's syndrome
Brain, October 1, 2001; 124(10): 2045 - 2058.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Lebedev, D. K. Douglass, S. L. Moody, and S. P. Wise
Prefrontal Cortex Neurons Reflecting Reports of a Visual Illusion
J Neurophysiol, April 1, 2001; 85(4): 1395 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J.-B. Pochon, R. Levy, J.-B. Poline, S. Crozier, S. Lehericy, B. Pillon, B. Deweer, D. Le Bihan, and B. Dubois
The Role of Dorsolateral Prefrontal Cortex in the Preparation of Forthcoming Actions: an fMRI Study
Cereb Cortex, March 1, 2001; 11(3): 260 - 266.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. R. Olson, S. N. Gettner, V. Ventura, R. Carta, and R. E. Kass
Neuronal Activity in Macaque Supplementary Eye Field During Planning of Saccades in Response to Pattern and Spatial Cues
J Neurophysiol, September 1, 2000; 84(3): 1369 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. P. Hasegawa, M. Matsumoto, and A. Mikami
Search Target Selection in Monkey Prefrontal Cortex
J Neurophysiol, September 1, 2000; 84(3): 1692 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Hoshi, K. Shima, and J. Tanji
Neuronal Activity in the Primate Prefrontal Cortex in the Process of Motor Selection Based on Two Behavioral Rules
J Neurophysiol, April 1, 2000; 83(4): 2355 - 2373.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Sawaguchi and I. Yamane
Properties of Delay-Period Neuronal Activity in the Monkey Dorsolateral Prefrontal Cortex During a Spatial Delayed Matching-to-Sample Task
J Neurophysiol, November 1, 1999; 82(5): 2070 - 2080.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online