| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 79 No. 1 January 1998,
pp. 392-409
Copyright ©1998 The American Physiological Society
1 Centre de Recherche en Sciences Neurologiques, Faculté de Médecine, Université de Montréal; and 2 School of Physical and Occupational Therapy, McGill University, Montreal, Quebec H3T 1J4, Canada
Chau, Connie, Hugues Barbeau, and Serge Rossignol. Early locomotor training with clonidine in spinal cats. J. Neurophysiol. 79: 392-409, 1998. Clonidine, a noradrenergic alpha-2 agonist, can initiate locomotion early after spinalization in cats. Because this effect lasts 4-6 h, we have injected clonidine daily, intraperitoneally or intrathecally, and intensively trained five spinal cats to perform hindlimb walking on a treadmill starting at day 3 and continuing until 10 days posttransection. Each day, clonidine was injected to induce locomotor activity and cats were trained to walk with as much weight support as possible and at different speeds during multiple (1-5) locomotor training sessions, each lasting from 10 to 20 min, until the effects of clonidine wore off. Electromyographic (EMG) activity synchronized to video images of the hindlimbs were recorded before and after each clonidine injection. The results showed, first, a day-to-day change of the locomotor pattern induced by clonidine from the 3rd to the 11th day including an increase in the duration of the step cycle, an increase in the duration of extensor EMG activity, and an increase in total angular excursion of the hip, knee, and ankle joints. Second, after 6-11 days of this regimen, there was an emergence of a coordinated locomotor pattern with weight support of the hindquarters that was visible even before that day's clonidine injection. The results suggested that daily injection of clonidine followed by early and daily interactive locomotor training can enhance the recovery of locomotion in spinal cats.
This article has been cited by other articles:
|
|
 |
|
  H. Delivet-Mongrain, H. Leblond, and S. Rossignol Effects of Localized Intraspinal Injections of a Noradrenergic Blocker on Locomotion of High Decerebrate Cats J Neurophysiol, August 1, 2008; 100(2): 907 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rossignol, M. Schwab, M. Schwartz, and M. G. Fehlings Spinal Cord Injury: Time to Move? J. Neurosci., October 31, 2007; 27(44): 11782 - 11792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Barthelemy, H. Leblond, and S. Rossignol Characteristics and Mechanisms of Locomotion Induced by Intraspinal Microstimulation and Dorsal Root Stimulation in Spinal Cats J Neurophysiol, March 1, 2007; 97(3): 1986 - 2000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Barthelemy, H. Leblond, J. Provencher, and S. Rossignol Nonlocomotor and Locomotor Hindlimb Responses Evoked by Electrical Microstimulation of the Lumbar Cord in Spinalized Cats J Neurophysiol, December 1, 2006; 96(6): 3273 - 3292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rossignol Plasticity of connections underlying locomotor recovery after central and/or peripheral lesions in the adult mammals Phil Trans R Soc B, September 29, 2006; 361(1473): 1647 - 1671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Langlet, H. Leblond, and S. Rossignol Mid-Lumbar Segments Are Needed for the Expression of Locomotion in Chronic Spinal Cats J Neurophysiol, May 1, 2005; 93(5): 2474 - 2488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-P. Cote and J.-P. Gossard Step Training-Dependent Plasticity in Spinal Cutaneous Pathways J. Neurosci., December 15, 2004; 24(50): 11317 - 11327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Dietz and S. J. Harkema Locomotor activity in spinal cord-injured persons J Appl Physiol, May 1, 2004; 96(5): 1954 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rossignol and L. Bouyer Adaptive Mechanisms of Spinal Locomotion in Cats Integr. Comp. Biol., February 1, 2004; 44(1): 71 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-P. Cote, A. Menard, and J.-P. Gossard Spinal Cats on the Treadmill: Changes in Load Pathways J. Neurosci., April 1, 2003; 23(7): 2789 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Barbeau Locomotor Training in Neurorehabilitation: Emerging Rehabilitation Concepts Neurorehabil Neural Repair, March 1, 2003; 17(1): 3 - 11. [PDF]
|
|
|
|
|
|
C. Chau, N. Giroux, H. Barbeau, L. Jordan, and S. Rossignol Effects of Intrathecal Glutamatergic Drugs on Locomotion I. NMDA in Short-Term Spinal Cats J Neurophysiol, December 1, 2002; 88(6): 3032 - 3045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rossignol Locomotion and its Recovery after Spinal Injury in Animal Models Neurorehabil Neural Repair, June 1, 2002; 16(2): 201 - 206. [PDF]
|
|
|
|
|
|
D. N. Loy, D. S. K. Magnuson, Y. P. Zhang, S. M. Onifer, M. D. Mills, Q.-l. Cao, J. B. Darnall, L. C. Fajardo, D. A. Burke, and S. R. Whittemore Functional Redundancy of Ventral Spinal Locomotor Pathways J. Neurosci., January 1, 2002; 22(1): 315 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. MacKay-Lyons Central Pattern Generation of Locomotion: A Review of the Evidence Physical Therapy, January 1, 2002; 82(1): 69 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D de Leon, R. R Roy, and V R. Edgerton Is the Recovery of Stepping Following Spinal Cord Injury Mediated by Modifying Existing Neural Pathways or by Generating New Pathways? A Perspective Physical Therapy, December 1, 2001; 81(12): 1904 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Giroux, T. A. Reader, and S. Rossignol Comparison of the Effect of Intrathecal Administration of Clonidine and Yohimbine on the Locomotion of Intact and Spinal Cats J Neurophysiol, June 1, 2001; 85(6): 2516 - 2536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Rossignol, N Giroux, C Chau, J Marcoux, E Brustein, and T A Reader Pharmacological aids to locomotor training after spinal injury in the cat J. Physiol., May 15, 2001; 533(1): 65 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Thompson, R. Parmer, P. J. Reier, D. C. Wang, and P. Bose Scientific Basis of Spasticity: Insights from a Laboratory Model J Child Neurol, January 1, 2001; 16(1): 2 - 9. [Abstract] [PDF]
|
|
|
|
|
|
M. G. y Ribotta, J. Provencher, D. Feraboli-Lohnherr, S. Rossignol, A. Privat, and D. Orsal Activation of Locomotion in Adult Chronic Spinal Rats Is Achieved by Transplantation of Embryonic Raphe Cells Reinnervating a Precise Lumbar Level J. Neurosci., July 1, 2000; 20(13): 5144 - 5152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Macpherson and J. Fung Weight Support and Balance During Perturbed Stance in the Chronic Spinal Cat J Neurophysiol, December 1, 1999; 82(6): 3066 - 3081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kim, V. Adipudi, M. Shibayama, S. Giszter, A. Tessler, M. Murray, and K. J. Simansky Direct Agonists for Serotonin Receptors Enhance Locomotor Function in Rats that Received Neural Transplants after Neonatal Spinal Transection J. Neurosci., July 15, 1999; 19(14): 6213 - 6224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. de Leon, H. Tamaki, J. A. Hodgson, R. R. Roy, and V. R. Edgerton Hindlimb Locomotor and Postural Training Modulates Glycinergic Inhibition in the Spinal Cord of the Adult Spinal Cat J Neurophysiol, July 1, 1999; 82(1): 359 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Brustein and S. Rossignol Recovery of Locomotion After Ventral and Ventrolateral Spinal Lesions in the Cat. II. Effects of Noradrenergic and Serotoninergic Drugs J Neurophysiol, April 1, 1999; 81(4): 1513 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chau, H. Barbeau, and S. Rossignol Effects of Intrathecal alpha 1- and alpha 2-Noradrenergic Agonists and Norepinephrine on Locomotion in Chronic Spinal Cats J Neurophysiol, June 1, 1998; 79(6): 2941 - 2963. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
