JN Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 79: 1070-1080, 1998;
0022-3077/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow A corrigendum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (144)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boecker, H.
Right arrow Articles by Brooks, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boecker, H.
Right arrow Articles by Brooks, D. J.

The Journal of Neurophysiology Vol. 79 No. 2 February 1998, pp. 1070-1080
Copyright ©1998 The American Physiological Society

Role of the Human Rostral Supplementary Motor Area and the Basal Ganglia in Motor Sequence Control: Investigations With H2 15O PET

H. Boecker1, 2, A. Dagher1, A. O. Ceballos-Baumann1, 2, R. E. Passingham3, M. Samuel1, K. J. Friston1, J.-B. Poline1, C. Dettmers1, B. Conrad2, and D. J. Brooks1

1 Medical Research Council Cyclotron Unit, Hammersmith Hospitals, London W12 OHS; 2 Department of Neurology, Technical University of Munich, D-81675 Munich, Germany; and 3 Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom

Boecker, H., A. Dagher, A. O. Ceballos-Baumann, R. E. Passingham, M. Samuel, K. J. Friston, J.-B. Poline, C. Dettmers, B. Conrad, and D. J. Brooks. Role of the human rostral supplementary motor area and the basal ganglia in motor sequence control: investigations with H2 15O PET. J. Neurophysiol. 79: 1070-1080, 1998. The aim of this study was to investigate the functional anatomy of distributed cortical and subcortical motor areas in the human brain that participate in the central control of overlearned complex sequential unimanual finger movements. On the basis of previous research in nonhuman primates, a principal involvement of basal ganglia (medial premotor loops) was predicted for central control of finger sequences performed automatically. In pertinent areas, a correlation of activation levels with the complexity of a motor sequence was hypothesized. H2 15O positron emission tomography (PET) was used in a group of seven healthy male volunteers [mean age 32.0 ± 10.4 yr] to determine brain regions where levels of regional cerebral blood flow (rCBF) correlated with graded complexity levels of five different key-press sequences. All sequences were overlearned before PET and involved key-presses of fingers II-V of the right hand. Movements of individual fingers were kept constant throughout all five conditions by external pacing at 1-Hz intervals. Positive correlations of rCBF with increasing sequence complexity were identified in the contralateral rostral supplementary motor area (pre-SMA) and the associated pallido-thalamic loop, as well as in right parietal area 7 and ipsilateral primary motor cortex (M1). In contrast, while rCBF in contralateral M1 and and extensive parts of caudal SMA was increased compared with rest during task performance, significant correlated increases of rCBF with sequence complexity were not observed. Inverse correlations of rCBF with increasing sequence complexity were identified in mesial prefrontal-, medial temporal-, and anterior cingulate areas. The findings provide further evidence in humans supporting the notion of a segregation of SMA into functionally distinct subcomponents: although pre-SMA was differentially activated depending on the complexity of a sequence of learned finger movements, such modulation was not detectable in caudal SMA (except the most antero-superior part), implicating a motor executive role. Our observations of complexity-correlated rCBF increases in anterior globus palllidus suggest a specific role for the basal ganglia in the process of sequence facilitation and control. They may act to filter and focus input from motor cortical areas as patterns of action become increasingly complex.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
J.-R. Duann, J. S. Ide, X. Luo, and C.-s. R. Li
Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition
J. Neurosci., August 12, 2009; 29(32): 10171 - 10179.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
B.F.L. van Nuenen, M. M. Weiss, B. R. Bloem, K. Reetz, T. van Eimeren, K. Lohmann, J. Hagenah, P. P. Pramstaller, F. Binkofski, C. Klein, et al.
Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
Neurology, March 24, 2009; 72(12): 1041 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Desmurget and R. S. Turner
Testing Basal Ganglia Motor Functions Through Reversible Inactivations in the Posterior Internal Globus Pallidus
J Neurophysiol, March 1, 2008; 99(3): 1057 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Garraux, P. Peigneux, R. E. Carson, and M. Hallett
Task-Related Interaction between Basal Ganglia and Cortical Dopamine Release
J. Neurosci., December 26, 2007; 27(52): 14434 - 14441.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
L. A Boyd, E. D Vidoni, and J. J Daly
Answering the Call: The Influence of Neuroimaging and Electrophysiological Evidence on Rehabilitation
Physical Therapy, June 1, 2007; 87(6): 684 - 703.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
R. B. Postuma and A. Dagher
Basal Ganglia Functional Connectivity Based on a Meta-Analysis of 126 Positron Emission Tomography and Functional Magnetic Resonance Imaging Publications
Cereb Cortex, October 1, 2006; 16(10): 1508 - 1521.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
D. Ongur, T. J. Cullen, D. H. Wolf, M. Rohan, P. Barreira, M. Zalesak, and S. Heckers
The neural basis of relational memory deficits in schizophrenia.
Arch Gen Psychiatry, April 1, 2006; 63(4): 356 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Lehericy, E. Bardinet, L. Tremblay, P.-F. Van de Moortele, J.-B. Pochon, D. Dormont, D.-S. Kim, J. Yelnik, and K. Ugurbil
Motor control in basal ganglia circuits using fMRI and brain atlas approaches
Cereb Cortex, February 1, 2006; 16(2): 149 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K. J. Jantzen, B. Anderson, F. L Steinberg, and J. A. S. Kelso
A Prospective Functional MR Imaging Study of Mild Traumatic Brain Injury in College Football Players
AJNR Am. J. Neuroradiol., May 1, 2004; 25(5): 738 - 745.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Wu, K. Kansaku, and M. Hallett
How Self-Initiated Memorized Movements Become Automatic: A Functional MRI Study
J Neurophysiol, April 1, 2004; 91(4): 1690 - 1698.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. Pinto, S. Thobois, N. Costes, D. Le Bars, A.-L. Benabid, E. Broussolle, P. Pollak, and M. Gentil
Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study
Brain, March 1, 2004; 127(3): 602 - 615.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. W. Kennerley, K. Sakai, and M.F.S. Rushworth
Organization of Action Sequences and the Role of the Pre-SMA
J Neurophysiol, February 1, 2004; 91(2): 978 - 993.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Kobayashi, S. Hutchinson, H. Theoret, G. Schlaug, and A. Pascual-Leone
Repetitive TMS of the motor cortex improves ipsilateral sequential simple finger movements
Neurology, January 13, 2004; 62(1): 91 - 98.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
I. Miyai, H. Yagura, M. Hatakenaka, I. Oda, I. Konishi, and K. Kubota
Longitudinal Optical Imaging Study for Locomotor Recovery After Stroke
Stroke, December 1, 2003; 34(12): 2866 - 2870.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
L. A Boyd and C. J Winstein
Impact of Explicit Information on Implicit Motor-Sequence Learning Following Middle Cerebral Artery Stroke
Physical Therapy, November 1, 2003; 83(11): 976 - 989.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. S. Ross, J. Tkach, P. M. Ruggieri, M. Lieber, and E. Lapresto
The Mind's Eye: Functional MR Imaging Evaluation of Golf Motor Imagery
AJNR Am. J. Neuroradiol., June 1, 2003; 24(6): 1036 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Taniwaki, A. Okayama, T. Yoshiura, Y. Nakamura, Y. Goto, J.-i. Kira, and S. Tobimatsu
Reappraisal of the Motor Role of Basal Ganglia: A Functional Magnetic Resonance Image Study
J. Neurosci., April 15, 2003; 23(8): 3432 - 3438.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. J. Mentis, V. Dhawan, T. Nakamura, M. F. Ghilardi, A. Feigin, C. Edwards, C. Ghez, and D. Eidelberg
Enhancement of brain activation during trial-and-error sequence learning in early PD
Neurology, February 25, 2003; 60(4): 612 - 619.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Maquet, S. Schwartz, R. Passingham, and C. Frith
Sleep-Related Consolidation of a Visuomotor Skill: Brain Mechanisms as Assessed by Functional Magnetic Resonance Imaging
J. Neurosci., February 15, 2003; 23(4): 1432 - 1440.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
I. K. Goerendt, C. Messa, A. D. Lawrence, P. M. Grasby, P. Piccini, and D. J. Brooks
Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study
Brain, February 1, 2003; 126(2): 312 - 325.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. Escola, Th. Michelet, F. Macia, D. Guehl, B. Bioulac, and P. Burbaud
Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: A clue to the pathophysiology of akinesia?
Brain, January 1, 2003; 126(1): 95 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
B. D. Acuna, J. C. Eliassen, J. P. Donoghue, and J. N. Sanes
Frontal and Parietal Lobe Activation during Transitive Inference in Humans
Cereb Cortex, December 1, 2002; 12(12): 1312 - 1321.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Sawamoto, M. Honda, T. Hanakawa, H. Fukuyama, and H. Shibasaki
Cognitive Slowing in Parkinson's Disease: A Behavioral Evaluation Independent of Motor Slowing
J. Neurosci., June 15, 2002; 22(12): 5198 - 5203.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K. Yamada, R. G. Gonzalez, L. Ostergaard, S. Komili, R. M. Weisskoff, B. R. Rosen, W. J. Koroshetz, T. Nishimura, and A. G. Sorensen
Iron-Induced Susceptibility Effect at the Globus Pallidus Causes Underestimation of Flow and Volume on Dynamic Susceptibility Contrast-Enhanced MR Perfusion Images
AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 1022 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
S. Sestini, A. Scotto di Luzio, F. Ammannati, M. T. R. De Cristofaro, A. Passeri, S. Martini, and A. Pupi
Changes in Regional Cerebral Blood Flow Caused by Deep-Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
J. Nucl. Med., June 1, 2002; 43(6): 725 - 732.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. R. Siebner, C. Limmer, A. Peinemann, A. Drzezga, B. R. Bloem, M. Schwaiger, and B. Conrad
Long-Term Consequences of Switching Handedness: A Positron Emission Tomography Study on Handwriting in "Converted" Left-Handers
J. Neurosci., April 1, 2002; 22(7): 2816 - 2825.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M.A. Maier, J. Armand, P.A. Kirkwood, H.-W. Yang, J.N. Davis, and R.N. Lemon
Differences in the Corticospinal Projection from Primary Motor Cortex and Supplementary Motor Area to Macaque Upper Limb Motoneurons: An Anatomical and Electrophysiological Study
Cereb Cortex, March 1, 2002; 12(3): 281 - 296.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P Johannsen, L O D Christensen, T Sinkjaer, and J B Nielsen
Cerebral functional anatomy of voluntary contractions of ankle muscles in man
J. Physiol., September 1, 2001; 535(2): 397 - 406.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. Weilke, S. Spiegel, H. Boecker, H. G. von Einsiedel, B. Conrad, M. Schwaiger, and P. Erhard
Time-Resolved fMRI of Activation Patterns in M1 and SMA During Complex Voluntary Movement
J Neurophysiol, May 1, 2001; 85(5): 1858 - 1863.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
B. Haslinger, P. Erhard, N. Kampfe, H. Boecker, E. Rummeny, M. Schwaiger, B. Conrad, and A. O. Ceballos-Baumann
Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa
Brain, March 1, 2001; 124(3): 558 - 570.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Shima and J. Tanji
Neuronal Activity in the Supplementary and Presupplementary Motor Areas for Temporal Organization of Multiple Movements
J Neurophysiol, October 1, 2000; 84(4): 2148 - 2160.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
O. Hikosaka, Y. Takikawa, and R. Kawagoe
Role of the Basal Ganglia in the Control of Purposive Saccadic Eye Movements
Physiol Rev, July 1, 2000; 80(3): 953 - 978.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. van Donkelaar, J. F. Stein, R. E. Passingham, and R. C. Miall
Temporary Inactivation in the Primate Motor Thalamus During Visually Triggered and Internally Generated Limb Movements
J Neurophysiol, May 1, 2000; 83(5): 2780 - 2790.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
U. Sabatini, K. Boulanouar, N. Fabre, F. Martin, C. Carel, C. Colonnese, L. Bozzao, I. Berry, J. L. Montastruc, F. Chollet, et al.
Cortical motor reorganization in akinetic patients with Parkinson's disease: A functional MRI study
Brain, February 1, 2000; 123(2): 394 - 403.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Dagher, A. M. Owen, H. Boecker, and D. J. Brooks
Mapping the network for planning: a correlational PET activation study with the Tower of London task
Brain, October 1, 1999; 122(10): 1973 - 1987.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. van Donkelaar, J. F. Stein, R. E. Passingham, and R. C. Miall
Neuronal Activity in the Primate Motor Thalamus During Visually Triggered and Internally Generated Limb Movements
J Neurophysiol, August 1, 1999; 82(2): 934 - 945.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Matsumoto, T. Hanakawa, S. Maki, A. M. Graybiel, and M. Kimura
Nigrostriatal Dopamine System in Learning to Perform Sequential Motor Tasks in a Predictive Manner
J Neurophysiol, August 1, 1999; 82(2): 978 - 998.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. O. Ceballos-Baumann, H. Boecker, P. Bartenstein, I. von Falkenhayn, H. Riescher, B. Conrad, J. R. Moringlane, and F. Alesch
A Positron Emission Tomographic Study of Subthalamic Nucleus Stimulation in Parkinson Disease: Enhanced Movement-Related Activity of Motor-Association Cortex and Decreased Motor Cortex Resting Activity
Arch Neurol, August 1, 1999; 56(8): 997 - 1003.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Shima and J. Tanji
Both Supplementary and Presupplementary Motor Areas Are Crucial for the Temporal Organization of Multiple Movements
J Neurophysiol, December 1, 1998; 80(6): 3247 - 3260.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. T. Grafton, E. Hazeltine, and R. B. Ivry
Abstract and Effector-Specific Representations of Motor Sequences Identified with PET
J. Neurosci., November 15, 1998; 18(22): 9420 - 9428.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online