JN Journal of Neurophysiology
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J Neurophysiol 79: 1102-1107, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 79 No. 2 February 1998, pp. 1102-1107
Copyright ©1998 The American Physiological Society

RAPID COMMUNICATION


Dose-Dependent Reduction of Cerebral Blood Flow During Rapid-Rate Transcranial Magnetic Stimulation of the Human Sensorimotor Cortex

Tomás Paus1, Robert Jech2, Christopher J. Thompson1, Roch Comeau1, Terry Peters1, and Alan C. Evans1

1 Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada; and 2 Department of Neurology, First Medical Faculty, Charles University, 12000 Prague, Czech Republic

Paus, Tomás, Robert Jech, Christopher J. Thompson, Roch Comeau, Terry Peters, and Alan C. Evans. Dose-dependent reduction of cerebral blood flow during rapid-rate transcranial magnetic stimulation of the human sensorimotor cortex. J. Neurophysiol. 79: 1102-1107, 1998. Rapid-rate transcranial magnetic stimulation (rTMS) was used to stimulate the primary sensorimotor cortex in six healthy volunteers while regional changes in cerebral blood flow (CBF) were simultaneously measured by means of positron emission tomography. A figure-eight TMS coil (Cadwell Corticoil) was positioned, using frameless stereotaxy, over the probabilistic location of the left primary sensorimotor cortex, and a series of brief 10-Hz trains of TMS was delivered at subthreshold intensity during each of six 60-s scans. The scans differed in the number of trains delivered, namely 5, 10, 15, 20, 25, and 30 trains/scan, respectively. In the left primary sensorimotor cortex, CBF covaried significantly and negatively with the number of stimulus trains. These CBF decreases may reflect TMS-induced activation of local inhibitory mechanisms known to play a role in TMS-related phenomena, such as the electromyographic silent period.




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