JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 79: 688-694, 1998;
0022-3077/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moore, K. A.
Right arrow Articles by Weinreich, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moore, K. A.
Right arrow Articles by Weinreich, D.

The Journal of Neurophysiology Vol. 79 No. 2 February 1998, pp. 688-694
Copyright ©1998 The American Physiological Society

Ca2+-Induced Ca2+ Release Mediates a Slow Post-Spike Hyperpolarization in Rabbit Vagal Afferent Neurons

Kimberly A. Moore1, Akiva S. Cohen1, Joseph P. Y. Kao2, and Daniel Weinreich1

1 Department of Pharmacology and Experimental Therapeutics; and 2 Medical Biotechnology Center and Department of Physiology, University of Maryland, School of Medicine, Baltimore, Maryland 21201-1559

Moore, Kimberly A., Akiva S. Cohen, Joseph P. Y. Kao, and Daniel Weinreich. Ca2+-induced Ca2+ release mediates a slow post-spike hyperpolarization in rabbit vagal afferent neurons. J. Neurophysiol. 79: 688-694, 1998. The relation between Ca2+-induced Ca2+ release (CICR) elicited by action potentials (APs) and a Ca2+-dependent slow post-spike hyperpolarization (AHPslow) in acutely dissociated adult rabbit nodose neurons was studied using microfluorimetric calcium measurements in conjunction with standard intracellular current- and voltage-clamp recording techniques. The magnitude of the AP-induced transient increase in [Ca2+]i (Delta Cat) was used to monitor CICR. There was a close correlation between the magnitude of the Delta Cat and the AHPslow current over the range of 1-16 APs (r = 0.985). Functional CICR blockers, ryanodine (10 µM), thapsigargin (100 nM), 2,5-di(t-butyl)hydroquinone (10 µM) or cyclopiazonic acid (10 µM), selectively reduced the peak amplitude of the AHPslow >= 91%. In five neurons, simultaneous recordings of the Delta Cat and the AHPslow revealed that both responses were blocked in parallel. These findings indicate that CICR is necessary for the generation of the AHPslow in rabbit nodose neurons. The Delta Cat rises and decays significantly faster than the AHPslow. This temporal disparity suggests that activation of the AHPslow by Ca2+ may require additional signal transduction steps.




This article has been cited by other articles:


Home page
 Learn. Mem.Home page
N. Galeotti, A. Quattrone, E. Vivoli, M. Norcini, A. Bartolini, and C. Ghelardini
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes
Learn. Mem., April 25, 2008; 15(5): 315 - 323.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. D. Gover, T. H. V. Moreira, J. P. Y. Kao, and D. Weinreich
Calcium regulation in individual peripheral sensory nerve terminals of the rat
J. Physiol., January 15, 2007; 578(2): 481 - 490.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. G. Jackson and S. A. Thayer
Mitochondrial Modulation of Ca2+-Induced Ca2+-Release in Rat Sensory Neurons
J Neurophysiol, September 1, 2006; 96(3): 1093 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Verkhratsky
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Physiol Rev, January 1, 2005; 85(1): 201 - 279.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. E. Hoesch, D. Weinreich, and J. P. Y. Kao
Localized IP3-Evoked Ca2+ Release Activates a K+ Current in Primary Vagal Sensory Neurons
J Neurophysiol, May 1, 2004; 91(5): 2344 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. A. Locknar, K. L. Barstow, J. D. Tompkins, L. A. Merriam, and R. L. Parsons
Calcium-induced calcium release regulates action potential generation in guinea-pig sympathetic neurones
J. Physiol., March 15, 2004; 555(3): 627 - 635.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. L. Parsons, K. L. Barstow, and F. S. Scornik
Spontaneous Miniature Hyperpolarizations Affect Threshold for Action Potential Generation in Mudpuppy Cardiac Neurons
J Neurophysiol, September 1, 2002; 88(3): 1119 - 1127.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. E. Hoesch, K. Yienger, D. Weinreich, and J. P. Y. Kao
Coexistence of Functional IP3 and Ryanodine Receptors in Vagal Sensory Neurons and Their Activation by ATP
J Neurophysiol, September 1, 2002; 88(3): 1212 - 1219.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Vanden Berghe, J. L. Kenyon, and T. K. Smith
Mitochondrial Ca2+ Uptake Regulates the Excitability of Myenteric Neurons
J. Neurosci., August 15, 2002; 22(16): 6962 - 6971.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. E. Hoesch, D. Weinreich, and J. P. Y. Kao
A Novel Ca2+ Influx Pathway in Mammalian Primary Sensory Neurons Is Activated by Caffeine
J Neurophysiol, July 1, 2001; 86(1): 190 - 196.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. A. Abdulla and P. A. Smith
Axotomy- and Autotomy-Induced Changes in the Excitability of Rat Dorsal Root Ganglion Neurons
J Neurophysiol, February 1, 2001; 85(2): 630 - 643.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Hillsley, J. L. Kenyon, and T. K. Smith
Ryanodine-Sensitive Stores Regulate the Excitability of AH Neurons in the Myenteric Plexus of Guinea-Pig Ileum
J Neurophysiol, December 1, 2000; 84(6): 2777 - 2785.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Martinez-Pinna, P. J. Davies, and E. M. McLachlan
Diversity of Channels Involved in Ca2+ Activation of K+ Channels During the Prolonged AHP in Guinea-Pig Sympathetic Neurons
J Neurophysiol, September 1, 2000; 84(3): 1346 - 1354.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. A. Merriam, F. S. Scornik, and R. L. Parsons
Ca2+-Induced Ca2+ Release Activates Spontaneous Miniature Outward Currents (SMOCs) in Parasympathetic Cardiac Neurons
J Neurophysiol, August 1, 1999; 82(2): 540 - 550.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Cordoba-Rodriguez, K. A. Moore, J. P. Y. Kao, and D. Weinreich
Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons
PNAS, July 6, 1999; 96(14): 7650 - 7657.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. M. Sandler and J.-G. Barbara
Calcium-Induced Calcium Release Contributes to Action Potential-Evoked Calcium Transients in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., June 1, 1999; 19(11): 4325 - 4336.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Sah and J. D. Clements
Photolytic Manipulation of [Ca2+]i Reveals Slow Kinetics of Potassium Channels Underlying the Afterhyperpolarization in Hipppocampal Pyramidal Neurons
J. Neurosci., May 15, 1999; 19(10): 3657 - 3664.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online