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J Neurophysiol 79: 1349-1359, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 79 No. 3 March 1998, pp. 1349-1359
Copyright ©1998 The American Physiological Society

Sodium-Gated Cation Channel Implicated in the Activation of Lobster Olfactory Receptor Neurons

Aslbek B. Zhainazarov1, Richard E. Doolin1, 3, and Barry W. Ache1, 2, 3

1 Whitney Laboratory, 2 Department of Zoology, and 3 Department of Neuroscience, University of Florida, St. Augustine, Florida 32086-8623

Zhainazarov, Aslbek B., Richard E. Doolin, and Barry W. Ache. Sodium-gated cation channel implicated in the activation of lobster olfactory receptor neurons. J. Neurophysiol. 79: 1349-1359, 1998. The role of Na+-activated channels in cellular function, if any, is still elusive. We have attempted to implicate a Na+-activated nonselective cation channel in the activation of lobster olfactory receptor neurons. We show that a Na+-activated channel occurs in the odor-detecting outer dendrites. With the use of pharmacological blockers of the channel together with ion substitution, we show that a substantial part of the odor-evoked depolarization in these cells can be ascribed to a Na+-activated conductance. We hypothesize, therefore, that the Na+-activated channel amplifies the receptor current as a result of being secondarily activated by the primary odor transduction pathway.




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