| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 79 No. 3 March 1998,
pp. 1597-1602
Copyright ©1998 The American Physiological Society
RAPID COMMUNICATION
Department of Anatomy, Visual/Motor Neuroscience Division, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0709
Meredith, M. Alex and Ary S. Ramoa. Intrinsic circuitry of the superior colliculus: pharmacophysiological identification of horizontally oriented inhibitory interneurons. J. Neurophysiol. 79: 1597-1602, 1998. Much of what is known about the organization of the superior colliculus is based on the arrangement of its external connections. Consequently, there is little information regarding pathways that remain intrinsic to it, even though recent data suggest that a horizontally oriented local circuit may mediate the functional reciprocity among fixation and saccade-related neurons. Therefore, the present experiments sought physiological evidence for neurons intrinsic to the superior colliculus that might participate in a horizontally oriented local circuit. Parasagittal slices of the ferret superior colliculus were prepared for in vitro recording, and 125 intermediate/deep layer neurons were examined in response to electrical stimulation rostral or caudal to the recording site. A substantial proportion (37%) of neurons responded with a prolonged period (means = 59.3 ± 30 ms) of poststimulus suppression of spontaneous action potential activity. Of the suppressed neurons, most (53%) were disinhibited when the excitatory amino acid receptor antagonists D-2-amino-5-phosphonovaleric acid (D-APV) and 6-nitro-7 sulphamoylbeno[f]-quinoxaline-2,3-dione (NBQX) were administered, indicating that excitatory input to inhibitory interneurons was blocked. Of the neurons that received inputs from inhibitory interneurons, all had their suppressive responses decreased or eliminated by the 
-aminobutyric acid antagonist, bicuculline. Finally, severing the superficial layers from the slice had no effect on intermediate layer responses to intrinsic stimulation. These data provide physiological evidence for the presence of horizontally oriented inhibitory interneurons in the superior colliculus. Furthermore, these findings are consistent with the hypothesis that an intrinsic circuit, routed through interneurons, might account for the reciprocal inhibition observed among fixation and saccade-related neurons.
This article has been cited by other articles:
|
|
 |
|
  S. A. Stevenson, J. K. Elsley, and B. D. Corneil A "Gap Effect" on Stop Signal Reaction Times in a Human Saccadic Countermanding Task J Neurophysiol, February 1, 2009; 101(2): 580 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sooksawate, K. Isa, and T. Isa Cholinergic Responses in Crossed Tecto-Reticular Neurons of Rat Superior Colliculus J Neurophysiol, November 1, 2008; 100(5): 2702 - 2711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Phongphanphanee, K. Kaneda, and T. Isa Spatiotemporal Profiles of Field Potentials in Mouse Superior Colliculus Analyzed by Multichannel Recording J. Neurosci., September 10, 2008; 28(37): 9309 - 9318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McPeek Reversal of a Distractor Effect on Saccade Target Selection After Superior Colliculus Inactivation J Neurophysiol, May 1, 2008; 99(5): 2694 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Dorris, E. Olivier, and D. P. Munoz Competitive Integration of Visual and Preparatory Signals in the Superior Colliculus during Saccadic Programming J. Neurosci., May 9, 2007; 27(19): 5053 - 5062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nakahara, K. Morita, R. H. Wurtz, and L. M. Optican Saccade-Related Spread of Activity Across Superior Colliculus May Arise From Asymmetry of Internal Connections J Neurophysiol, August 1, 2006; 96(2): 765 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lee and W. C. Hall An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. J. Neurosci., May 3, 2006; 26(18): 4763 - 4768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li and M. A. Basso Competitive Stimulus Interactions within Single Response Fields of Superior Colliculus Neurons J. Neurosci., December 7, 2005; 25(49): 11357 - 11373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Razak and S. L. Pallas Neural Mechanisms of Stimulus Velocity Tuning in the Superior Colliculus J Neurophysiol, November 1, 2005; 94(5): 3573 - 3589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Perrault Jr., J. W. Vaughan, B. E. Stein, and M. T. Wallace Superior Colliculus Neurons Use Distinct Operational Modes in the Integration of Multisensory Stimuli J Neurophysiol, May 1, 2005; 93(5): 2575 - 2586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Watanabe, Y. Kobayashi, Y. Inoue, and T. Isa Effects of Local Nicotinic Activation of the Superior Colliculus on Saccades in Monkeys J Neurophysiol, January 1, 2005; 93(1): 519 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Skaliora, T. P. Doubell, N. P. Holmes, F. R. Nodal, and A. J. King Functional Topography of Converging Visual and Auditory Inputs to Neurons in the Rat Superior Colliculus J Neurophysiol, November 1, 2004; 92(5): 2933 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Dehner, L. P. Keniston, H. R. Clemo, and M. A. Meredith Cross-modal Circuitry Between Auditory and Somatosensory Areas of the Cat Anterior Ectosylvian Sulcal Cortex: A 'New' Inhibitory Form of Multisensory Convergence Cereb Cortex, April 1, 2004; 14(4): 387 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Port and R. H. Wurtz Sequential Activity of Simultaneously Recorded Neurons in the Superior Colliculus During Curved Saccades J Neurophysiol, September 1, 2003; 90(3): 1887 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Saito and T. Isa Local Excitatory Network and NMDA Receptor Activation Generate a Synchronous and Bursting Command from the Superior Colliculus J. Neurosci., July 2, 2003; 23(13): 5854 - 5864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Corneil, E. Olivier, and D. P. Munoz Neck Muscle Responses to Stimulation of Monkey Superior Colliculus. I. Topography and Manipulation of Stimulation Parameters J Neurophysiol, October 1, 2002; 88(4): 1980 - 1999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Corneil, M. Van Wanrooij, D. P. Munoz, and A. J. Van Opstal Auditory-Visual Interactions Subserving Goal-Directed Saccades in a Complex Scene J Neurophysiol, July 1, 2002; 88(1): 438 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.F.W. Neggers and H. Bekkering Gaze Anchoring to a Pointing Target Is Present During the Entire Pointing Movement and Is Driven by a Non-Visual Signal J Neurophysiol, August 1, 2001; 86(2): 961 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J J. Zhu and F.-S. Lo Recurrent inhibitory circuitry in the deep layers of the rabbit superior colliculus J. Physiol., March 15, 2000; 523(3): 731 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.F.W. Neggers and H. Bekkering Ocular Gaze is Anchored to the Target of an Ongoing Pointing Movement J Neurophysiol, February 1, 2000; 83(2): 639 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Gandhi and E. L. Keller Comparison of Saccades Perturbed by Stimulation of the Rostral Superior Colliculus, the Caudal Superior Colliculus, and the Omnipause Neuron Region J Neurophysiol, December 1, 1999; 82(6): 3236 - 3253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Gandhi and E. L. Keller Activity of the Brain Stem Omnipause Neurons During Saccades Perturbed by Stimulation of the Primate Superior Colliculus J Neurophysiol, December 1, 1999; 82(6): 3254 - 3267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Pettit, M. C. Helms, P. Lee, G. J. Augustine, and W. C. Hall Local Excitatory Circuits in the Intermediate Gray Layer of the Superior Colliculus J Neurophysiol, March 1, 1999; 81(3): 1424 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. King, J. W. H. Schnupp, and I. D. Thompson Signals from the Superficial Layers of the Superior Colliculus Enable the Development of the Auditory Space Map in the Deeper Layers J. Neurosci., November 15, 1998; 18(22): 9394 - 9408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Munoz and P. J. Istvan Lateral Inhibitory Interactions in the Intermediate Layers of the Monkey Superior Colliculus J Neurophysiol, March 1, 1998; 79(3): 1193 - 1209. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
