| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 79 No. 4 April 1998,
pp. 1790-1796
Copyright ©1998 The American Physiological Society
1 Department of Neurosurgery, 2 Department of Neurobiology, 3 Department of Experimental Psychology, and 4 Department of Psychiatry, Duke University, Durham 27705; and 5 Durham Veterans Affairs Medical Center,Durham, North Carolina 27710
Pyapali, Gowri K., Dennis A. Turner, Christina L. Williams, Warren H. Meck, and H. Scott Swartzwelder. Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats. J. Neurophysiol. 79: 1790-1796, 1998. Choline supplementation during gestation in rats leads to augmentation of spatial memory in adulthood. We hypothesized that prenatal (E12-E17) choline supplementation in the rat would lead to an enhancement of hippocampal synaptic plasticity as assessed by long-term potentiation (LTP) at 3-4 mo of age. LTP was assessed blindly in area CA1 of hippocampal slices with first suprathreshold (above threshold for LTP generation in control slices) theta-burst stimulus trains. The magnitude of potentiation after these stimuli was not different between slices from control and prenatally choline supplemented animals. Next, threshold (reliably leading to LTP generation in control slices) or subthreshold theta-burst stimulus trains were applied to slices from control, prenatally choline-supplemented, and prenatally choline-deprived rats. Threshold level stimulus trains induced LTP in slices from both the control and choline-supplemented rats but not in those from the choline-deficient rats. Subthreshold stimulus trains led to LTP induction in slices from prenatally choline-supplemented rats only. These observations indicate that prenatal dietary manipulation of the amino acid, choline, leads to subsequent significant alterations of LTP induction threshold in adult animals.
This article has been cited by other articles:
|
|
 |
|
  S. H Zeisel Epigenetic mechanisms for nutrition determinants of later health outcomes Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1488S - 1493S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Davison, T. J. Mellott, V. P. Kovacheva, and J. K. Blusztajn Gestational Choline Supply Regulates Methylation of Histone H3, Expression of Histone Methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA Methylation of Their Genes in Rat Fetal Liver and Brain J. Biol. Chem., January 23, 2009; 284(4): 1982 - 1989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Lamoureux, W. H. Meck, and C. L. Williams Prenatal choline availability alters the context sensitivity of Pavlovian conditioning in adult rats Learn. Mem., December 2, 2008; 15(12): 866 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-K. Cheng, C. J. MacDonald, C. L. Williams, and W. H. Meck Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior Learn. Mem., March 5, 2008; 15(3): 153 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Resseguie, J. Song, M. D. Niculescu, K.-A. da Costa, T. A. Randall, and S. H. Zeisel Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes FASEB J, August 1, 2007; 21(10): 2622 - 2632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Mellott, M. T. Follettie, V. Diesl, A. A. Hill, I. Lopez-Coviella, and J. K. Blusztajn Prenatal choline availability modulates hippocampal and cerebral cortical gene expression FASEB J, May 1, 2007; 21(7): 1311 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-A. da Costa, O. G. Kozyreva, J. Song, J. A. Galanko, L. M. Fischer, and S. H. Zeisel Common genetic polymorphisms affect the human requirement for the nutrient choline FASEB J, July 1, 2006; 20(9): 1336 - 1344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Alkondon and E. X. Albuquerque Subtype-Specific Inhibition of Nicotinic Acetylcholine Receptors by Choline: A Regulatory Pathway J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 268 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cho, S. H Zeisel, P. Jacques, J. Selhub, L. Dougherty, G. A Colditz, and W. C Willett Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 905 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-K. Cheng, W. H. Meck, and C. L. Williams {alpha}7 Nicotinic acetylcholine receptors and temporal memory: Synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock Learn. Mem., March 1, 2006; 13(2): 127 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Li, S. Guo-Ross, D. V. Lewis, D. Turner, A. M. White, W. A. Wilson, and H. S. Swartzwelder Dietary Prenatal Choline Supplementation Alters Postnatal Hippocampal Structure and Function J Neurophysiol, April 1, 2004; 91(4): 1545 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-L. E. YEN, M.-H. MAR, R. B. MEEKER, A. FERNANDES, and S. H. ZEISEL Choline deficiency induces apoptosis in primary cultures of fetal neurons FASEB J, August 1, 2001; 15(10): 1704 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Zeisel Choline: Needed for Normal Development of Memory J. Am. Coll. Nutr., October 1, 2000; 19(90005): 528S - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H Zeisel Is there a metabolic basis for dietary supplementation? Am. J. Clinical Nutrition, August 1, 2000; 72(2): 507S - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-l. E. Yen, M.-h. Mar, and S. H. Zeisel Choline deficiency-induced apoptosis in PC12 cells is associated with diminished membrane phosphatidylcholine and sphingomyelin, accumulation of ceramide and diacylglycerol, and activation of a caspase FASEB J, January 1, 1999; 13(1): 135 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yang, Z. Liu, J. M. Cermak, P. Tandon, M. R. Sarkisian, C. E. Stafstrom, J. C. Neill, J. K. Blusztajn, and G. L. Holmes Protective Effects of Prenatal Choline Supplementation on Seizure-Induced Memory Impairment J. Neurosci., November 15, 2000; 20(22): RC109 - RC109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. X. Guo-Ross, S. Clark, D. A. C. Montoya, K. H. Jones, J. Obernier, A. K. Shetty, A. M. White, J. K. Blusztajn, W. A. Wilson, and H. S. Swartzwelder Prenatal Choline Supplementation Protects against Postnatal Neurotoxicity J. Neurosci., January 1, 2002; 22(1): RC195 - RC195. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
