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J Neurophysiol 79: 2013-2024, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 79 No. 4 April 1998, pp. 2013-2024
Copyright ©1998 The American Physiological Society

Development of Excitatory Circuitry in the Hippocampus

Albert Y. Hsia1, 2, 4, Robert C. Malenka2, 3, and Roger A. Nicoll2, 4

1 Neuroscience Graduate Program, 2 Department of Physiology, 3 Department of Psychiatry, and 4 Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143

Hsia, Albert Y., Robert C. Malenka, and Roger A. Nicoll. Development of excitatory circuitry in the hippocampus. J. Neurophysiol. 79: 2013-2024, 1998. Assessing the development of local circuitry in the hippocampus has relied primarily on anatomic studies. Here we take a physiological approach, to directly evaluate the means by which the mature state of connectivity between CA3 and CA1 hippocampal pyramidal cells is established. Using a technique of comparing miniature excitatory postsynaptic currents (mEPSCs) to EPSCs in response to spontaneously occurring action potentials in CA3 cells, we found that from neonatal to adult ages, functional synapses are created and serve to increase the degree of connectivity between CA3-CA1 cell pairs. Neither the probability of release nor mean quantal size was found to change significantly with age. However, the variability of quantal events decreases substantially as synapses mature. Thus in the hippocampus the developmental strategy for enhancing excitatory synaptic transmission does not appear to involve an increase in the efficacy at individual synapses, but rather an increase in the connectivity between cell pairs.




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