| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 79 No. 4 April 1998,
pp. 2063-2069
Copyright ©1998 The American Physiological Society
Section of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853
Ayali, Amir, Bruce R. Johnson, and Ronald M. Harris-Warrick. Dopamine modulates graded and spike-evoked synaptic inhibition independently at single synapses in pyloric network of lobster. J. Neurophysiol. 79: 2063-2069, 1998. Bath application of dopamine (DA) modifies the rhythmic motor pattern generated by the pyloric network in the stomatogastric ganglion of the spiny lobster, Panulirus interruptus. Synaptic transmission between network members is an important target of DA action. All pyloric neurons employ both graded transmitter release and action-potential-mediated synaptic inhibition. DA was previously shown to alter the graded synaptic strength of every pyloric synapse. In this study, we compared DA's effects on action-potential-mediated and graded synaptic inhibition at output synapses of the lateral pyloric (LP) neuron. At each synapse the postsynaptic cell tested was isolated from other descending and pyloric synaptic inputs. DA caused a reduction in the size of the LP spike-evoked inhibitory postsynaptic potentials (IPSPs) in the pyloric dilator (PD) neuron. The change in IPSP size was significantly and linearly correlated with DA-induced reduction in the input resistance of the postsynaptic PD neuron. In contrast, graded inhibition, tested in the same preparations after superfusing the stomatogastric ganglion (STG) with tetrodotoxin (TTX), was consistently enhanced by DA. DA shifted the amplitude of spike-evoked IPSPs in the same direction as the alteration of the postsynaptic cell input resistance at two additional synapses tested: DA weakened the LP spike-mediated inhibition of the ventricular dilator (VD) and reduced the VD input resistance, while strengthening the LP 
pyloric constrictor (PY) synapse and increasing PY input resistance. As previously reported, graded inhibition was enhanced at these two LP output synapses. We conclude that DA can differentially modulate the spike-evoked and graded components of synapses between members of a central pattern generator network. At the synapses we studied, actions on the presynaptic cell predominate in the modulation of graded transmission, whereas effects on postsynaptic cells predominate in the regulation of spike-evoked IPSPs.
This article has been cited by other articles:
|
|
 |
|
  A. I. Ivanov and R. L. Calabrese Spike-Mediated and Graded Inhibitory Synaptic Transmission Between Leech Interneurons: Evidence for Shared Release Sites J Neurophysiol, July 1, 2006; 96(1): 235 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Thirumalai, A. A. Prinz, C. D. Johnson, and E. Marder Red Pigment Concentrating Hormone Strongly Enhances the Strength of the Feedback to the Pyloric Rhythm Oscillator But Has Little Effect on Pyloric Rhythm Period J Neurophysiol, March 1, 2006; 95(3): 1762 - 1770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Johnson, L. R. Schneider, F. Nadim, and R. M. Harris-Warrick Dopamine Modulation of Phasing of Activity in a Rhythmic Motor Network: Contribution of Synaptic and Intrinsic Modulatory Actions J Neurophysiol, November 1, 2005; 94(5): 3101 - 3111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gruhn, J. Guckenheimer, B. Land, and R. M. Harris-Warrick Dopamine Modulation of Two Delayed Rectifier Potassium Currents in a Small Neural Network J Neurophysiol, October 1, 2005; 94(4): 2888 - 2900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bucher, A. A. Prinz, and E. Marder Animal-to-Animal Variability in Motor Pattern Production in Adults and during Growth J. Neurosci., February 16, 2005; 25(7): 1611 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Crisp and K. A. Mesce A cephalic projection neuron involved in locomotion is dye coupled to the dopaminergic neural network in the medicinal leech J. Exp. Biol., December 15, 2004; 207(26): 4535 - 4542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Johnson, P. Kloppenburg, and R. M. Harris-Warrick Dopamine Modulation of Calcium Currents in Pyloric Neurons of the Lobster Stomatogastric Ganglion J Neurophysiol, August 1, 2003; 90(2): 631 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bucher, V. Thirumalai, and E. Marder Axonal Dopamine Receptors Activate Peripheral Spike Initiation in a Stomatogastric Motor Neuron J. Neurosci., July 30, 2003; 23(17): 6866 - 6875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Prinz, V. Thirumalai, and E. Marder The Functional Consequences of Changes in the Strength and Duration of Synaptic Inputs to Oscillatory Neurons J. Neurosci., February 1, 2003; 23(3): 943 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Cymbalyuk, Q. Gaudry, M. A. Masino, and R. L. Calabrese Bursting in Leech Heart Interneurons: Cell-Autonomous and Network-Based Mechanisms J. Neurosci., December 15, 2002; 22(24): 10580 - 10592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Thoby-Brisson and J. Simmers Long-Term Neuromodulatory Regulation of a Motor Pattern-Generating Network: Maintenance of Synaptic Efficacy and Oscillatory Properties J Neurophysiol, December 1, 2002; 88(6): 2942 - 2953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Narusuye and T. Nagahama Cerebral CBM1 Neuron Contributes to Synaptic Modulation Appearing During Rejection of Seaweed in Aplysia kurodai J Neurophysiol, November 1, 2002; 88(5): 2778 - 2795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nagahama, K. Narusuye, and H. Arai Synaptic Modulation Contributes to Firing Pattern Generation in Jaw Motor Neurons During Rejection of Seaweed in Aplysia kurodai J Neurophysiol, November 1, 1999; 82(5): 2579 - 2589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Blitz and M. P. Nusbaum Distinct Functions for Cotransmitters Mediating Motor Pattern Selection J. Neurosci., August 15, 1999; 19(16): 6774 - 6783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ayali and R. M. Harris-Warrick Monoamine Control of the Pacemaker Kernel and Cycle Frequency in the Lobster Pyloric Network J. Neurosci., August 1, 1999; 19(15): 6712 - 6722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Blitz, A. E. Christie, M. J. Coleman, B. J. Norris, E. Marder, and M. P. Nusbaum Different Proctolin Neurons Elicit Distinct Motor Patterns from a Multifunctional Neuronal Network J. Neurosci., July 1, 1999; 19(13): 5449 - 5463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kloppenburg, R. M. Levini, and R. M. Harris-Warrick Dopamine Modulates Two Potassium Currents and Inhibits the Intrinsic Firing Properties of an Identified Motor Neuron in a Central Pattern Generator Network J Neurophysiol, January 1, 1999; 81(1): 29 - 38. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
