JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 79: 2383-2393, 1998;
0022-3077/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koos, B. J.
Right arrow Articles by Kruger, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koos, B. J.
Right arrow Articles by Kruger, L.

The Journal of Neurophysiology Vol. 79 No. 5 May 1998, pp. 2383-2393
Copyright ©1998 The American Physiological Society

Thalamic Locus Mediates Hypoxic Inhibition of Breathing in Fetal Sheep

Brian J. Koos, Andrew Chau, Masahiko Matsuura, Oscar Punla, and Lawrence Kruger

Departments of Obstetrics and Gynecology and Neurobiology, Nicholas S. Assali Perinatal Research Laboratory, Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095-1740

Koos, Brian J., Andrew Chau, Masahiko Matsuura, Oscar Punla, and Lawrence Kruger. Thalamic locus mediates hypoxic inhibition of breathing in fetal sheep. J. Neurophysiol. 79: 2383-2393, 1998. The effects of lesions rostral to the brain stem on breathing responses to hypoxia were determined in chronically catheterized fetal sheep (>0.8 term). These studies were designed to test the hypothesis that the diencephalon is involved in hypoxic inhibition of fetal breathing. As in normal fetuses, hypoxia inhibited breathing with transection rostral to the thalamus or transection resulting in virtual destruction of the thalamus but sparing most of the parafascicular nuclear complex. Neuronal lesions were produced in the fetal diencephalon by injecting ibotenic acid through cannulas implanted in the brain. Hypoxic inhibition of breathing was abolished when the lesions encompassed the parafascicular nuclear complex but was retained when the lesions spared the parafascicular nuclear region or when the vehicle alone was injected. A new locus has been identified immediately rostral to the midbrain, which is crucial to hypoxic inhibition of fetal breathing. This thalamic sector involves the parafascicular nuclear complex and may link central O2-sensing cells to motoneurons that inhibit breathing.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. B. Yan, A. A. Baburamani, A. M. Walker, and D. W. Walker
Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2009; 297(1): R60 - R69.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. L. Powell
Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxia by D'Agostino D, Mazza E, and Neubauer JA
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R100 - R101.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Macey, M. A. Woo, K. E. Macey, T. G. Keens, M. M. Saeed, J. R. Alger, and R. M. Harper
Hypoxia reveals posterior thalamic, cerebellar, midbrain, and limbic deficits in congenital central hypoventilation syndrome
J Appl Physiol, March 1, 2005; 98(3): 958 - 969.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. M. Harper, P. M. Macey, M. A. Woo, K. E. Macey, T. G. Keens, D. Gozal, and J. R. Alger
Hypercapnic Exposure in Congenital Central Hypoventilation Syndrome Reveals CNS Respiratory Control Mechanisms
J Neurophysiol, March 1, 2005; 93(3): 1647 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. J. Koos, Y. Kawasaki, A. Hari, F. Bohorquez, C. Jan, J. Roostaeian, C. L. Wilson, and L. Kruger
Electrical stimulation of the posteromedial thalamus modulates breathing in unanesthetized fetal sheep
J Appl Physiol, January 1, 2004; 96(1): 115 - 123.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Neubauer and J. Sunderram
Oxygen-sensing neurons in the central nervous system
J Appl Physiol, January 1, 2004; 96(1): 367 - 374.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. C. Johnston, V. Singh, H. J. Ralston III, and W. M. Gold
Chronic dyspnea and hyperventilation in an awake patient with small subcortical infarcts
Neurology, December 11, 2001; 57(11): 2131 - 2133.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. J. Koos, T. Maeda, and C. Jan
Adenosine A1 and A2A receptors modulate sleep state and breathing in fetal sheep
J Appl Physiol, July 1, 2001; 91(1): 343 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Bissonnette
Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1391 - R1400.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. Koos, A. Chau, M. Matsuura, O. Punla, and L. Kruger
Thalamic lesions dissociate breathing inhibition by hypoxia and adenosine in fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2000; 278(4): R831 - R837.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Chau and B. J. Koos
Metabolic and cardiorespiratory responses to hypoxia in fetal sheep: adenosine receptor blockade
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1805 - R1811.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online