The Journal of Neurophysiology Vol. 79 No. 5 May 1998, pp. 2522-2534
Copyright ©1998 The American Physiological Society

Specificity in the Interaction of HVA Ca²⁺ Channel Types With Ca²⁺-Dependent AHPs and Firing Behavior in Neocortical Pyramidal Neurons

Juan Carlos Pineda, Robert S. Waters, and Robert C. Foehring

Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163

Pineda, Juan Carlos, Roberts S. Waters, and Robert C. Foehring. Specificity in the interaction of HVA Ca²⁺ channel types with Ca²⁺-dependent AHPs and firing behavior in neocortical pyramidal neurons. J. Neurophysiol. 79: 2522-2534, 1998. Intracellular recordings and organic and inorganic Ca²⁺ channel blockers were used in a neocortical brain slice preparation to test whether high-voltage-activated (HVA) Ca²⁺ channels are differentially coupled to Ca²⁺-dependent afterhyperpolarizations (AHPs) in sensorimotor neocortical pyramidal neurons. For the most part, spike repolarization was not Ca²⁺ dependent in these cells, although the final phase of repolarization (after the fast AHP) was sensitive to block of N-type current. Between 30 and 60% of the medium afterhyperpolarization (mAHP) and between ~80 and 90% of the slow AHP (sAHP) were Ca²⁺ dependent. Based on the effects of specific organic Ca²⁺ channel blockers (dihydropyridines, -conotoxin GVIA, -agatoxin IVA, and -conotoxin MVIIC), the sAHP is coupled to N-, P-, and Q-type currents. P-type currents were coupled to the mAHP. L-type current was not involved in the generation of either AHP but (with other HVA currents) contributes to the inward currents that regulate interspike intervals during repetitive firing. These data suggest different functional consequences for modulation of Ca²⁺ current subtypes.

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