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J Neurophysiol 80: 621-627, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 80 No. 2 August 1998, pp. 621-627
Copyright ©1998 The American Physiological Society

Activation of Group I mGluRs Increases Spontaneous IPSC Frequency in Rat Frontal Cortex

Zhiguo Chu1, 2 and John J. Hablitz1

1 Department of Neurobiology and 2 Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0021

Chu, Zhiguo and John J. Hablitz. Activation of group I mGluRs increases spontaneous IPSC frequency in rat frontal cortex. J. Neurophysiol. 80: 621-627, 1998. The effect of metabotropic glutamate receptor (mGluR) activation on inhibitory synaptic transmission was examined by using whole cell patch-clamp recordings. Spontaneous (s) and miniature (m) inhibitory postsynaptic currents (IPSCs) were recorded from visually identified layer II/III pyramidal neurons in rat neocortex in vitro. Excitatory postsynaptic currents (EPSCs) were blocked by using bath application of 20 µM D(-)2-amino-5-phosphonovaleric acid and 10 µM 6-cyano-7-nitroquinoxaline-2,3-dione. In the presence of 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (30-100 µM), L-quisqualate (5 µM), and the group I selective mGluR agonist (S)-3,5-dihydroxyphenylglycine (100 µM), the frequency of sIPSCs was increased. Decay kinetics of sIPSCs were unaffected. No enhancement of mIPSCs was observed. Bath application of group II (2S,3S,4S-alpha -carboxycyclopropyl-glycine; 5 µM) and group III selective mGluR agonists (L-2-amino-4-phosphonobutyric acid; 100 µM) had no detectable effects on the frequency or amplitude of sIPSCs. These findings indicate that activation of group I mGluRs (mGluR1 and/or mGluR5) enhances gamma -aminobutyric acid-mediated synaptic inhibition in layer II/III pyramidal neurons in neocortex. The lack of effect on mIPSCs suggests a presynaptic action via excitation of inhibitory interneurons.




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