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J Neurophysiol 80: 895-902, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 80 No. 2 August 1998, pp. 895-902
Copyright ©1998 The American Physiological Society

Low-Affinity Kainate Receptors and Long-Lasting Depression of NMDA-Receptor-Mediated Currents in Rat Superficial Dorsal Horn

Sandra Sequeira and Jacques Näsström

Department of Cellular and Molecular Pharmacology, Discovery Division, Astra Pain Control AB, S-141 57 Huddinge, Sweden

Sequeira, Sandra and Jacques Näsström. Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn. J. Neurophysiol. 80: 895-902, 1998. In an in vitro spinal cord slice preparation whole cell electrophysiological recordings of rat superficial dorsal horn neurons responding differentially to glutamate (Glu) and N-methyl-D-aspartate (NMDA) were investigated systematically for the role of kainate (KA) receptors in modulating their activity. In these neurons, coapplication of Glu and NMDA, as well as application of Glu immediately before NMDA, induced long- and short-lasting depressions of NMDA-induced currents as well as depression of NMDA-receptor-mediated excitatory postsynaptic currents. KA applied before NMDA mimicked Glu-induced attenuating effects. Furthermore, the low-affinity KA receptor antagonist 5-nitro-6,7,8,9- tetrahydrobenzo[G]indole-2,3-dione-3-oxime potentiated Glu-induced NMDA-receptor-mediated currents in neurons responding differentially to Glu and NMDA. These results provide evidence for a novel mechanism, which may relate to classical long-term depression, involving low-affinity KA receptors in long-lasting modulation of NMDA-receptor-mediated currents. This implies a physiological role of KA receptors in long-term modulation of sensory transmission in the superficial dorsal horn of rat spinal cord.






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