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J Neurophysiol 80: 978-982, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 80 No. 2 August 1998, pp. 978-982
Copyright ©1998 The American Physiological Society

RAPID COMMUNICATION


Initiation of Spontaneous Epileptiform Activity in the Neocortical Slice

Yang Tsau, Li Guan, and Jian-Young Wu

Institute for Cognitive and Computational Sciences, Georgetown University Medical Center, Washington, DC 20007

Tsau, Yang, Li Guan, and Jian-Young Wu. Initiation of spontaneous epileptiform activity in the neocortical slice. J. Neurophysiol. 80: 978-982, 1998. Cortical local circuitry is important in epileptogenesis. Voltage-sensitive dyes and fast imaging were used to visualize the initiation of spontaneous paroxysmal events in adult rat neocortical slices. Although spontaneous paroxysmal events could start from anywhere in the preparation, optical imaging revealed that all spontaneous events started at a few confined initiation foci and propagated to the whole preparation. Multielectrode recording over hundreds of spontaneous events revealed that often two or three initiation foci coexisted in each preparation (n = 10). These foci took turns being dominant; the dominant focus initiated the majority of the spontaneous paroxysmal events during that period. The dominant focus and dynamic rearrangement of foci suggest that the initiation of spontaneous epileptiform events involves a local multineuronal process, perhaps with potentiated synapses.




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