| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 80 No. 3 September 1998,
pp. 1222-1235
Copyright ©1998 The American Physiological Society
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510
Kim, Uhnoh and David A. McCormick. Functional and ionic properties of a slow afterhyperpolarization in ferret perigeniculate neurons in vitro. J. Neurophysiol. 80: 1222-1235, 1998. Intracellular recordings from spontaneously spindling GABAergic neurons of the ferret perigeniculate nucleus in vitro revealed a fast afterhyperpolarization after each action potential, a medium-duration afterhyperpolarization after each low-threshold Ca2+ spike, and a slow afterhyperpolarization after the cessation of spindle waves. The slow afterhyperpolarization was associated with an increase in membrane conductance, and the reversal potential was sensitive to extracellular [K+]o, indicating that it is mediated at least in part by the activation of a K+ conductance. However, the block of Ca2+ channels did not block the slow afterhyperpolarization, whereas the block of Na+ channels did block this event, even after the generation of repetitive Ca2+ spikes, indicating that it is mediated by a Na+-activated K+ current. Application of apamin reduced the afterhyperpolarization and enhanced a plateau potential after each low-threshold Ca2+ spike. This plateau potential could result in a prolonged depolarization of perigeniculate neurons, even before the application of apamin, resulting in the generation of tonic discharge. The plateau potential was blocked by the local application of tetrodotoxin, indicating that it is mediated by a persistent Na+ current. The activation and interaction of these slowly developing and persistent currents contributes significantly to low-frequency components of spindle wave generation. In particular, we suggest that the activation of the slow afterhyperpolarization may contribute to the generation of the spindle wave refractory period in vitro.
This article has been cited by other articles:
|
|
 |
|
  P. Wallen, B. Robertson, L. Cangiano, P. Low, A. Bhattacharjee, L. K. Kaczmarek, and S. Grillner Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons J. Physiol., November 15, 2007; 585(1): 75 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Kim and L.-y. Chung Dual GABAergic Synaptic Response of Fast Excitation and Slow Inhibition in the Medial Habenula of Rat Epithalamus J Neurophysiol, September 1, 2007; 98(3): 1323 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tazerart, J.-C. Viemari, P. Darbon, L. Vinay, and F. Brocard Contribution of Persistent Sodium Current to Locomotor Pattern Generation in Neonatal Rats J Neurophysiol, August 1, 2007; 98(2): 613 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hess, E. Nanou, and A. El Manira Characterization of Na+-Activated K+ Currents in Larval Lamprey Spinal Cord Neurons J Neurophysiol, May 1, 2007; 97(5): 3484 - 3493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Aracri, E. Colombo, M. Mantegazza, P. Scalmani, G. Curia, G. Avanzini, and S. Franceschetti Layer-Specific Properties of the Persistent Sodium Current in Sensorimotor Cortex J Neurophysiol, June 1, 2006; 95(6): 3460 - 3468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Hains, C. Y. Saab, and S. G. Waxman Alterations in Burst Firing of Thalamic VPL Neurons and Reversal by Nav1.3 Antisense After Spinal Cord Injury J Neurophysiol, June 1, 2006; 95(6): 3343 - 3352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Llinas and M. Steriade Bursting of Thalamic Neurons and States of Vigilance J Neurophysiol, June 1, 2006; 95(6): 3297 - 3308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Blethyn, S. W. Hughes, T. I. Toth, D. W. Cope, and V. Crunelli Neuronal Basis of the Slow (<1 Hz) Oscillation in Neurons of the Nucleus Reticularis Thalami In Vitro J. Neurosci., March 1, 2006; 26(9): 2474 - 2486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Traub, D. Contreras, M. O. Cunningham, H. Murray, F. E. N. LeBeau, A. Roopun, A. Bibbig, W. B. Wilent, M. J. Higley, and M. A. Whittington Single-Column Thalamocortical Network Model Exhibiting Gamma Oscillations, Sleep Spindles, and Epileptogenic Bursts J Neurophysiol, April 1, 2005; 93(4): 2194 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. F. Descalzo, L. G. Nowak, J. C. Brumberg, D. A. McCormick, and M. V. Sanchez-Vives Slow Adaptation in Fast-Spiking Neurons of Visual Cortex J Neurophysiol, February 1, 2005; 93(2): 1111 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fuentealba, I. Timofeev, M. Bazhenov, T. J. Sejnowski, and M. Steriade Membrane Bistability in Thalamic Reticular Neurons During Spindle Oscillations J Neurophysiol, January 1, 2005; 93(1): 294 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Lee, C. Broberger, U. Kim, and D. A. McCormick Histamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons PNAS, April 27, 2004; 101(17): 6716 - 6721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bhattacharjee, W. J. Joiner, M. Wu, Y. Yang, F. J. Sigworth, and L. K. Kaczmarek Slick (Slo2.1), a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP J. Neurosci., December 17, 2003; 23(37): 11681 - 11691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Franceschetti, T. Lavazza, G. Curia, P. Aracri, F. Panzica, G. Sancini, G. Avanzini, and J. Magistretti Na+-Activated K+ Current Contributes to Postexcitatory Hyperpolarization in Neocortical Intrinsically Bursting Neurons J Neurophysiol, April 1, 2003; 89(4): 2101 - 2111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Cooke Reliable, Responsive Pacemaking and Pattern Generation With Minimal Cell Numbers: the Crustacean Cardiac Ganglion Biol. Bull., April 1, 2002; 202(2): 108 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sekirnjak and S. du Lac Intrinsic Firing Dynamics of Vestibular Nucleus Neurons J. Neurosci., March 15, 2002; 22(6): 2083 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Slaght, N. Leresche, J.-M. Deniau, V. Crunelli, and S. Charpier Activity of Thalamic Reticular Neurons during Spontaneous Genetically Determined Spike and Wave Discharges J. Neurosci., March 15, 2002; 22(6): 2323 - 2334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kurtz, V. Durr, and M. Egelhaaf Dendritic Calcium Accumulation Associated With Direction-Selective Adaptation in Visual Motion-Sensitive Neurons In Vivo J Neurophysiol, October 1, 2000; 84(4): 1914 - 1923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bazhenov, I. Timofeev, M. Steriade, and T. Sejnowski Spiking-Bursting Activity in the Thalamic Reticular Nucleus Initiates Sequences of Spindle Oscillations in Thalamic Networks J Neurophysiol, August 1, 2000; 84(2): 1076 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Sanchez-Vives, L. G. Nowak, and D. A. McCormick Cellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro J. Neurosci., June 1, 2000; 20(11): 4286 - 4299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Bevan and C. J. Wilson Mechanisms Underlying Spontaneous Oscillation and Rhythmic Firing in Rat Subthalamic Neurons J. Neurosci., September 1, 1999; 19(17): 7617 - 7628. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
