| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 80 No. 3 September 1998,
pp. 1480-1494
Copyright ©1998 The American Physiological Society
Laboratoire de Neurophysiologie, Faculté de Médecine, Université Laval, Quebec, Quebec G1K 7P4, Canada
Neckelmann, Dag, Florin Amzica, and Mircea Steriade. Spike-wave complexes and fast components of cortically generated seizures. III. Synchronizing mechanisms. J. Neurophysiol. 80: 1480-1494, 1998. The intracortical and thalamocortical synchronization of spontaneously occurring or bicuculline-induced seizures, consisting of spike-wave (SW) or polyspike-wave (PSW) complexes at 2-3 Hz and fast runs at 10-15 Hz, was investigated in cats under ketamine-xylazine anesthesia. We used single and dual simultaneous intracellular recordings from cortical areas 5 and 7, and extracellular recordings of unit firing and field potentials from neocortical areas 5, 7, 17, 18, as well as related thalamic nuclei. The evolution of time delays between paroxysmal depolarizing events in single neurons or neuronal pools recorded from adjacent and distant sites was analyzed by using 1) sequential cross-correlations between field potentials, 2) averaged activities triggered by the spiky component of cortical SW/PSW complexes, and 3) time histograms between neuronal discharges. In all instances, the paroxysmal activities recorded from the dorsal thalamus lagged the onset of seizures in neocortex. The time lags between simultaneously impaled cortical neurons were significantly smaller during SW complexes than during the prior epochs of slow oscillation. During seizures, as during the slow oscillation, the intracortical synchrony was reduced with increased distance between different cortical sites. Dual intracellular recordings showed that, during the same seizure, time lags were not constant and, instead, reflected alternating precession of the recorded foci. After transection between areas 5 and 7, the intracortical synchrony was lost, but corticothalamocortical volleys could partially restore seizure synchrony. These data show that the neocortex leads the thalamus during SW/PSW seizures, that time lags between cortical foci are not static, and that thalamus may assist synchronization of SW/PSW seizures after disconnection of intracortical synaptic linkages.
This article has been cited by other articles:
|
|
 |
|
  P.-O. Polack, I. Guillemain, E. Hu, C. Deransart, A. Depaulis, and S. Charpier Deep Layer Somatosensory Cortical Neurons Initiate Spike-and-Wave Discharges in a Genetic Model of Absence Seizures J. Neurosci., June 13, 2007; 27(24): 6590 - 6599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schindler, H. Leung, C. E. Elger, and K. Lehnertz Assessing seizure dynamics by analysing the correlation structure of multichannel intracranial EEG Brain, January 1, 2007; 130(1): 65 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Nita, Y. Cisse, I. Timofeev, and M. Steriade Increased Propensity to Seizures After Chronic Cortical Deafferentation In Vivo J Neurophysiol, February 1, 2006; 95(2): 902 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski Potassium Model for Slow (2-3 Hz) In Vivo Neocortical Paroxysmal Oscillations J Neurophysiol, August 1, 2004; 92(2): 1116 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Timofeev, F. Grenier, and M. Steriade Contribution of Intrinsic Neuronal Factors in the Generation of Cortically Driven Electrographic Seizures J Neurophysiol, August 1, 2004; 92(2): 1133 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Hurtado, L. L. Rubchinsky, and K. A. Sigvardt Statistical Method for Detection of Phase-Locking Episodes in Neural Oscillations J Neurophysiol, April 1, 2004; 91(4): 1883 - 1898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Topolnik, M. Steriade, and I. Timofeev Partial Cortical Deafferentation Promotes Development of Paroxysmal Activity Cereb Cortex, August 1, 2003; 13(8): 883 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kirchner, H. Stefan, M. Schmelz, K. M. Haslbeck, and F. Birklein Influence of vagus nerve stimulation on histamine-induced itching Neurology, July 9, 2002; 59(1): 108 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Slaght, N. Leresche, J.-M. Deniau, V. Crunelli, and S. Charpier Activity of Thalamic Reticular Neurons during Spontaneous Genetically Determined Spike and Wave Discharges J. Neurosci., March 15, 2002; 22(6): 2323 - 2334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. M. Meeren, J. P. M. Pijn, E. L. J. M. Van Luijtelaar, A. M. L. Coenen, and F. H. Lopes da Silva Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats J. Neurosci., February 15, 2002; 22(4): 1480 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Amzica, M. Massimini, and A. Manfridi Spatial Buffering during Slow and Paroxysmal Sleep Oscillations in Cortical Networks of Glial Cells In Vivo J. Neurosci., February 1, 2002; 22(3): 1042 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Steriade Impact of Network Activities on Neuronal Properties in Corticothalamic Systems J Neurophysiol, July 1, 2001; 86(1): 1 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Steriade The GABAergic reticular nucleus: A preferential target of corticothalamic projections PNAS, March 16, 2001; (2001) 71051998. [Full Text]
|
|
|
|
|
|
M. A. Castro-Alamancos Origin of Synchronized Oscillations Induced by Neocortical Disinhibition In Vivo J. Neurosci., December 15, 2000; 20(24): 9195 - 9206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Amzica and M. Steriade Neuronal and Glial Membrane Potentials during Sleep and Paroxysmal Oscillations in the Neocortex J. Neurosci., September 1, 2000; 20(17): 6648 - 6665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Blumenfeld and D. A. McCormick Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks J. Neurosci., July 1, 2000; 20(13): 5153 - 5162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Finnerty and J.G.R. Jefferys 9-16 Hz Oscillation Precedes Secondary Generalization of Seizures in the Rat Tetanus Toxin Model of Epilepsy J Neurophysiol, April 1, 2000; 83(4): 2217 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Steriade and F. Amzica Intracellular Study of Excitability in the Seizure-Prone Neocortex In Vivo J Neurophysiol, December 1, 1999; 82(6): 3108 - 3122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Amzica and M. Steriade Spontaneous and Artificial Activation of Neocortical Seizures J Neurophysiol, December 1, 1999; 82(6): 3123 - 3138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Golshani and E. G. Jones Synchronized Paroxysmal Activity in the Developing Thalamocortical Network Mediated by Corticothalamic Projections and "Silent" Synapses J. Neurosci., April 15, 1999; 19(8): 2865 - 2875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Steriade and D. Contreras Spike-Wave Complexes and Fast Components of Cortically Generated Seizures. I. Role of Neocortex and Thalamus J Neurophysiol, September 1, 1998; 80(3): 1439 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Steriade, F. Amzica, D. Neckelmann, and I. Timofeev Spike-Wave Complexes and Fast Components of Cortically Generated Seizures. II. Extra- and Intracellular Patterns J Neurophysiol, September 1, 1998; 80(3): 1456 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Timofeev, F. Grenier, and M. Steriade Spike-Wave Complexes and Fast Components of Cortically Generated Seizures. IV. Paroxysmal Fast Runs in Cortical and Thalamic Neurons J Neurophysiol, September 1, 1998; 80(3): 1495 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Steriade The GABAergic reticular nucleus: A preferential target of corticothalamic projections PNAS, March 27, 2001; 98(7): 3625 - 3627. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
