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The Journal of Neurophysiology Vol. 80 No. 3 September 1998,
pp. 1567-1570
Copyright ©1998 The American Physiological Society
RAPID COMMUNICATION
1 Department of Pharmacology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536; and 2 Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037
Norris, Christopher M., Shelley Halpain, and Thomas C. Foster. Alterations in the balance of protein kinase/phosphatase activities parallel reduced synaptic strength during aging. J. Neurophysiol. 80: 1567-1570, 1998. The current research examined the regulation of synaptic strength by protein phosphorylation during aging. Bath application of the protein phosphatase 1 and 2A (PP1 and PP2A) inhibitor calyculin A (1 µM) enhanced CA3-CA1 synaptic strength in hippocampal slices from aged male (20-24 mo) but not from young adult male (4-6 mo) Fischer 344 rats. Similarly, injection of the PP1 and PP2A inhibitor microcystin-L,R (5 µM) into CA1 cells caused an increase in the intracellular synaptic response only in slices from aged rats. In contrast, bath application of the serine/threonine kinase inhibitor H-7 (10 µM) induced a decrease in synaptic strength only in slices from the young adult group. These results demonstrate that phosphorylation-dependent regulation of intrinsic synaptic efficacy changes during aging.
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