| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 80 No. 4 October 1998,
pp. 2046-2062
Copyright ©1998 The American Physiological Society
1 Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland 20892-4435; and 2 Salk Institute for Biological Studies, La Jolla, California 92037
Krauzlis, R. J. and F. A. Miles. Role of the oculomotor vermis in generating pursuit and saccades: effects of microstimulation. J. Neurophysiol. 80: 2046-2062, 1998. We studied the eye movements evoked by applying small amounts of current (2-50 µA) within the oculomotor vermis of two monkeys. We first compared the eye movements evoked by microstimulation applied either during maintained pursuit or during fixation. Smooth, pursuitlike changes in eye velocity caused by the microstimulation were directed toward the ipsilateral side and occurred at short latencies (10-20 ms). The amplitudes of these pursuitlike changes were larger during visually guided pursuit toward the contralateral side than during either fixation or visually guided pursuit toward the ipsilateral side. At these same sites, microstimulation also often produced abrupt, saccadelike changes in eye velocity. In contrast to the smooth changes in eye velocity, these saccadelike effects were more prevalent during fixation and during pursuit toward the ipsilateral side. The amplitude and type of evoked eye movements could also be manipulated at single sites by changing the frequency of microstimulation. Increasing the frequency of microstimulation produced increases in the amplitude of pursuitlike changes, but only up to a certain point. Beyond this point, the value of which depended on the site and whether the monkey was fixating or pursuing, further increases in stimulation frequency produced saccadelike changes of increasing amplitude. To quantify these effects, we introduced a novel method for classifying eye movements as pursuitlike or saccadelike. The results of this analysis showed that the eye movements evoked by microstimulation exhibit a distinct transition point between pursuit and saccadelike effects and that the amplitude of eye movement that corresponds to this transition point depends on the eye movement behavior of the monkey. These results are consistent with accumulating evidence that the oculomotor vermis and its associated deep cerebellar nucleus, the caudal fastigial, are involved in the control of both pursuit and saccadic eye movements. We suggest that the oculomotor vermis might accomplish this role by altering the amplitude of a motor error signal that is common to both saccades and pursuit.
This article has been cited by other articles:
|
|
 |
|
  K. Miura, Y. Kobayashi, and K. Kawano Ocular Responses to Brief Motion of Textured Backgrounds During Smooth Pursuit in Humans J Neurophysiol, September 1, 2009; 102(3): 1736 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Cerminara, R. Apps, and D. E. Marple-Horvat An internal model of a moving visual target in the lateral cerebellum J. Physiol., January 15, 2009; 587(2): 429 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sander, A. Sprenger, G. Neumann, B. Machner, S. Gottschalk, H. Rambold, and C. Helmchen Vergence deficits in patients with cerebellar lesions Brain, January 1, 2009; 132(1): 103 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Catz, P. W. Dicke, and P. Thier Cerebellar-dependent motor learning is based on pruning a Purkinje cell population response PNAS, May 20, 2008; 105(20): 7309 - 7314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nitta, T. Akao, S. Kurkin, and K. Fukushima Involvement of the Cerebellar Dorsal Vermis in Vergence Eye Movements in Monkeys Cereb Cortex, May 1, 2008; 18(5): 1042 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Orban de Xivry and P. Lefevre Saccades and pursuit: two outcomes of a single sensorimotor process J. Physiol., October 1, 2007; 584(1): 11 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hufner, T. Stephan, R. Kalla, A. Deutschlander, J. Wagner, M. Holtmannspotter, G. Schulte-Altedorneburg, M. Strupp, T. Brandt, and S. Glasauer Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmus Neurology, September 11, 2007; 69(11): 1128 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hubner, A. Sprenger, C. Klein, J. Hagenah, H. Rambold, C. Zuhlke, D. Kompf, A. Rolfs, H. Kimmig, and C. Helmchen Eye movement abnormalities in spinocerebellar ataxia type 17 (SCA17) Neurology, September 11, 2007; 69(11): 1160 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schreiber, M. Missal, and P. Lefevre Asynchrony Between Position and Motion Signals in the Saccadic System J Neurophysiol, February 1, 2006; 95(2): 960 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Blohm, M. Missal, and P. Lefevre Direct Evidence for a Position Input to the Smooth Pursuit System J Neurophysiol, July 1, 2005; 94(1): 712 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takarae, N. J. Minshew, B. Luna, C. M. Krisky, and J. A. Sweeney Pursuit eye movement deficits in autism Brain, December 1, 2004; 127(12): 2584 - 2594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Krauzlis Recasting the Smooth Pursuit Eye Movement System J Neurophysiol, February 1, 2004; 91(2): 591 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Helmchen, A. Hagenow, J. Miesner, A. Sprenger, H. Rambold, R. Wenzelburger, W. Heide, and G. Deuschl Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction Brain, June 1, 2003; 126(6): 1319 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-M. Cui, Y.-J. Yan, and J. C. Lynch Pursuit Subregion of the Frontal Eye Field Projects to the Caudate Nucleus in Monkeys J Neurophysiol, May 1, 2003; 89(5): 2678 - 2684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Blohm, M. Missal, and P. Lefevre Interaction Between Smooth Anticipation and Saccades During Ocular Orientation in Darkness J Neurophysiol, March 1, 2003; 89(3): 1423 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Anderson, P. S. Christova, T.-d. Xie, K. S. Schott, K. Ward, and C. M. Gomez Spinocerebellar Ataxia in Monozygotic Twins Arch Neurol, December 1, 2002; 59(12): 1945 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-H. Zhou, M. Wei, and D. E. Angelaki Motor Scaling By Viewing Distance of Early Visual Motion Signals During Smooth Pursuit J Neurophysiol, November 1, 2002; 88(5): 2880 - 2885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Missal and E. L. Keller Common Inhibitory Mechanism for Saccades and Smooth-Pursuit Eye Movements J Neurophysiol, October 1, 2002; 88(4): 1880 - 1892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. de Brouwer, M. Missal, G. Barnes, and P. Lefevre Quantitative Analysis of Catch-Up Saccades During Sustained Pursuit J Neurophysiol, April 1, 2002; 87(4): 1772 - 1780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shinmei, T. Yamanobe, J. Fukushima, and K. Fukushima Purkinje Cells of the Cerebellar Dorsal Vermis: Simple-Spike Activity During Pursuit and Passive Whole-Body Rotation J Neurophysiol, April 1, 2002; 87(4): 1836 - 1849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. de Brouwer, D. Yuksel, G. Blohm, M. Missal, and P. Lefevre What Triggers Catch-Up Saccades During Visual Tracking? J Neurophysiol, March 1, 2002; 87(3): 1646 - 1650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka and S. G. Lisberger Enhancement of Multiple Components of Pursuit Eye Movement by Microstimulation in the Arcuate Frontal Pursuit Area in Monkeys J Neurophysiol, February 1, 2002; 87(2): 802 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Yan, D.-M. Cui, and J. C. Lynch Overlap of Saccadic and Pursuit Eye Movement Systems in the Brain Stem Reticular Formation J Neurophysiol, December 1, 2001; 86(6): 3056 - 3060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Krauzlis, M. A. Basso, and R. H. Wurtz Discharge Properties of Neurons in the Rostral Superior Colliculus of the Monkey During Smooth-Pursuit Eye Movements J Neurophysiol, August 1, 2000; 84(2): 876 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takagi, D. S. Zee, and R. J. Tamargo Effects of Lesions of the Oculomotor Cerebellar Vermis on Eye Movements in Primate: Smooth Pursuit J Neurophysiol, April 1, 2000; 83(4): 2047 - 2062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Missal, S. de Brouwer, P. Lefevre, and E. Olivier Activity of Mesencephalic Vertical Burst Neurons During Saccades and Smooth Pursuit J Neurophysiol, April 1, 2000; 83(4): 2080 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.F.W. Neggers and H. Bekkering Ocular Gaze is Anchored to the Target of an Ongoing Pointing Movement J Neurophysiol, February 1, 2000; 83(2): 639 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Moschner, T. J. Crawford, W. Heide, P. Trillenberg, D. Kompf, and C. Kennard Deficits of smooth pursuit initiation in patients with degenerative cerebellar lesions Brain, November 1, 1999; 122(11): 2147 - 2158. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
