| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 80 No. 4 October 1998,
pp. 2102-2112
Copyright ©1998 The American Physiological Society
1 Animal Health and Biomedical Sciences, The University of Wisconsin-Madison, Madison, Wisconsin 53706; and 2 Université Claude Bernard, Faculté de Médecine Alexis Carrel, 69372 Lyon, France
Danilova, Vicktoria, Göran Hellekant, Jean-Marie Tinti, and Claude Nofre. Gustatory responses of the hamster Mesocricetus auratus to various compounds considered sweet by humans. J. Neurophysiol. 80: 2102-2112, 1998. The taste of 30 compounds was studied in the golden hamster with three different methods: single-fiber recordings, two-bottle preference (TBP), and conditioned taste aversion (CTA) tests. On the whole, the results showed that the sense of taste in the hamster differs in many respects from that in humans because, of 26 tested compounds known as sweet to humans, 11 had no taste or tasted differently. The results also supported the notion that activity in S-fibers elicits liking and activity in Q- or H-fibers rejection. Specifically hierarchial cluster analysis of 36 single fibers from the chorda tympani proper nerve separated N-, H-, and S-clusters consisting of 11 sucrose-, 14 NaCl-, and 11 citric-best fibers. Ace-K, cyanosuosan, N-4-cyanophenyl-N'-cyanoguanidineacetate (CCGA), D-tryptophan, N-3,5-dichlorophenyl-N'-(S)-
-methylbenzylguanidineacetate (DMGA), saccharin, SC-45647, and suosan stimulated only the S-fibers, were significantly preferred in TBP tests, and generalized to sucrose in the CTA tests. Ethylene glycol stimulated the N-fibers in addition to the S-fibers. This explains its generalization to sucrose in CTA. Its toxicity may contribute to its rejection in TBP tests. Sodium cyclamate stimulated a few N- but no S-fibers, which may explain the nondiscriminatory TBP and CTA results. Glycine elicited its largest response in the S-fibers, although it also stimulated other fibers. The resulting mixed taste sensation may explain why it was not preferred in TBP, although it generalized to sucrose in the CTA. Alitame, aspartame, N-4-cyanophenylcarbamoyl-L-aspartyl-(R)--methylbenzylamine (CAM), N-4-cyanophenylcarbamoyl-(R, S)-3-amino-3-(3,4-methylenedioxyphenyl) propionic acid (CAMPA), N-(S)-2-methylhexanoyl-L-glutamyl-5-amino-2-pyridinecarbonitrile (MAGAP), N-1-naphthoyl-L-glutamyl-5-amino-2-pyridinecarbonitrile (NAGAP), NHDHC, superaspartame, and thaumatin were among the compounds considered sweet by humans that gave no response, were not discriminated in the TBP test, and gave no generalization in the CTA tests.
This article has been cited by other articles:
|
|
 |
|
  C. H. Lemon and R. F. Margolskee Contribution of the T1r3 Taste Receptor to the Response Properties of Central Gustatory Neurons J Neurophysiol, May 1, 2009; 101(5): 2459 - 2471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Dess, C. D. Chapman, and D. Monroe Consumption of SC45647 and Sucralose by Rats Selectively Bred for High and Low Saccharin Intake Chem Senses, March 1, 2009; 34(3): 211 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Jiang, G. Blonde, M. Garcea, and A. C. Spector Greater Superficial Petrosal Nerve Transection in Rats does not Change Unconditioned Licking Responses to Putatively Sweet Taste Stimuli Chem Senses, October 1, 2008; 33(8): 709 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Gordesky-Gold, N. Rivers, O. M. Ahmed, and P. A.S. Breslin Drosophila melanogaster Prefers Compounds Perceived Sweet by Humans Chem Senses, March 1, 2008; 33(3): 301 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Dotson and A. C. Spector Behavioral Discrimination between Sucrose and Other Natural Sweeteners in Mice: Implications for the Neural Coding of T1R Ligands J. Neurosci., October 17, 2007; 27(42): 11242 - 11253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Palmer The Pharmacology and Signaling of Bitter, Sweet, and Umami Taste Sensing Mol. Interv., April 1, 2007; 7(2): 87 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Manita, A. A. Bachmanov, X. Li, G. K. Beauchamp, and M. Inoue Is Glycine "Sweet" to Mice? Mouse Strain Differences in Perception of Glycine Taste Chem Senses, November 1, 2006; 31(9): 785 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Danilova, S. Damak, R. F. Margolskee, and G. Hellekant Taste Responses to Sweet Stimuli in {alpha}-Gustducin Knockout and Wild-Type Mice Chem Senses, July 1, 2006; 31(6): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Spector and S. P. Travers The representation of taste quality in the Mammalian nervous system. Behav Cogn Neurosci Rev, September 1, 2005; 4(3): 143 - 191. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Jiang, Q. Ji, Z. Liu, L. A. Snyder, L. M. J. Benard, R. F. Margolskee, and M. Max The Cysteine-rich Region of T1R3 Determines Responses to Intensely Sweet Proteins J. Biol. Chem., October 22, 2004; 279(43): 45068 - 45075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Eylam and A. C. Spector Stimulus Processing of Glycine is Dissociable from that of Sucrose and Glucose Based on Behaviorally Measured Taste Signal Detection in Sac 'Taster' and 'Non-taster' Mice Chem Senses, September 1, 2004; 29(7): 639 - 649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Danilova and G. Hellekant Sense of Taste in a New World Monkey, the Common Marmoset. II. Link Between Behavior and Nerve Activity J Neurophysiol, August 1, 2004; 92(2): 1067 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.R. Heyer, C.C. Taylor-Burds, L.H. Tran, and E.R. Delay Monosodium Glutamate and Sweet Taste: Generalization of Conditioned Taste Aversion between Glutamate and Sweet Stimuli in Rats Chem Senses, September 1, 2003; 28(7): 631 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Caicedo, K.-N. Kim, and S. D Roper Individual mouse taste cells respond to multiple chemical stimuli J. Physiol., October 15, 2002; 544(2): 501 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Danilova, Y. Danilov, T. Roberts, J.-M. Tinti, C. Nofre, and G. Hellekant Sense of Taste in a New World Monkey, the Common Marmoset: Recordings From the Chorda Tympani and Glossopharyngeal Nerves J Neurophysiol, August 1, 2002; 88(2): 579 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Bachmanov, M. G. Tordoff, and G. K. Beauchamp Sweetener Preference of C57BL/6ByJ and 129P3/J Mice Chem Senses, September 1, 2001; 26(7): 905 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Danilova, T. Roberts, and G. Hellekant Responses of Single Taste Fibers and Whole Chorda Tympani and Glossopharyngeal Nerve in the Domestic Pig, Sus scrofa Chem Senses, June 1, 1999; 24(3): 301 - 316. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
