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J Neurophysiol 80: 2467-2474, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 80 No. 5 November 1998, pp. 2467-2474
Copyright ©1998 The American Physiological Society

Cholinergic Agonist Carbachol Enables Associative Long-Term Potentiation in Piriform Cortex Slices

Madhvi M. Patil, Christiane Linster, Eugene Lubenov, and Michael E. Hasselmo

Department of Psychology, Harvard University, Cambridge, Massachusetts 02138

Patil, Madhvi M., Christiane Linster, Eugene Lubenov, and Michael E. Hasselmo. Cholinergic agonist carbachol enables associative long-term potentiation in piriform cortex slices. J. Neurophysiol. 80: 2467-2474, 1998. Pyramidal cells in piriform (olfactory) cortex receive afferent input from the olfactory bulb as well as intrinsic association input from piriform cortex and other cortical areas. These two functionally distinct inputs terminate on adjacent apical dendritic segments of the pyramidal cells located in layer Ia and layer Ib of piriform cortex. Studies with bath-applied cholinergic agonists have shown suppression of the fast component of the inhibitory postsynaptic potentials (IPSPs) evoked by stimulation of the association fibers. It was previously demonstrated that an associative form of LTP can be induced by coactivation of the two fiber systems after blockade of the fast, gamma -aminobutyric acid-A-mediated IPSP. In this report, we demonstrate that an associative form of long-term potentiation can be induced by coactivation of afferent and intrinsic fibers in the presence of the cholinergic agonist carbachol.




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