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J Neurophysiol 80: 3365-3368, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 80 No. 6 December 1998, pp. 3365-3368
Copyright ©1998 The American Physiological Society

RAPID COMMUNICATION


Neuronal Discriminator Formed by Metabotropic gamma -Aminobutyric Acid Receptors

Jian Zhang, Ning Tian, and Malcolm M. Slaughter

Department of Physiology and Biophysics, School of Medicine, State University of New York, Buffalo, New York 14214

Zhang, Jian, Ning Tian, and Malcolm M. Slaughter. Neuronal discriminator formed by metabotropic gamma -aminobutyric acid receptors. J. Neurophysiol. 80: 3365-3368, 1998. Neurotransmitters function in one of two modes, promoting either inhibition or excitation. However, the metabotropic gamma -aminobutyric acid receptor (GABABR) system can switch between these modes. In the presence of a small excitatory stimulus, the GABABR mediates a shunting inhibition that suppresses excitation. However, in the presence of a strong excitatory stimulus, the GABABR potentiates the response. This bipartite action is accomplished by linking the GABABR to two electrogenic mechanisms; one activates an outward current and another reduces an outward current. As a consequence, the GABABR serves as a discriminator that reduces the influence of weak signals while augmenting responses to strong signals. In retinal ganglion cells, this mechanism acts to promote the communication of phasic information.




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