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J Neurophysiol 80: 3383-3386, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 80 No. 6 December 1998, pp. 3383-3386
Copyright ©1998 The American Physiological Society

RAPID COMMUNICATION


Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus

M. Frerking1, R. C. Malenka2, 3, and R. A. Nicoll1, 2

1 Departments of Cellular and Molecular Pharmacology, 2 Physiology, and 3 Psychiatry, University of California, San Francisco, California 94143

Frerking, M., R. C. Malenka, and R. A. Nicoll. Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. J. Neurophysiol. 80: 3383-3386, 1998. Brain-derived neurotrophic factor (BDNF) has been reported to have rapid effects on synaptic transmission in the hippocampus. We report here that bath application of BDNF causes a small but significant decrease in stimulus-evoked inhibitory postsynaptic currents (IPSCs) on CA1 pyramidal cells, which is prevented by the tyrosine kinase inhibitor lavendustin A. BDNF causes a decrease in the 1/CV2 of the IPSC, and also reduces paired-pulse depression of the IPSC, suggesting a presynaptic site of action. In contrast, BDNF did not have a detectable effect on field excitatory postsynaptic potentials measured in stratum radiatum. We conclude that BDNF has a selective depressant action on inhibitory transmission in the hippocampus, due at least in part to a presynaptic mechanism.




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