JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 81: 371-382, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Woodhall, G.
Right arrow Articles by Lacaille, J.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Woodhall, G.
Right arrow Articles by Lacaille, J.-C.

The Journal of Neurophysiology Vol. 81 No. 1 January 1999, pp. 371-382
Copyright ©1999 The American Physiological Society

Membrane Potential and Intracellular Ca2+ Oscillations Activated by mGluRs in Hippocampal Stratum Oriens/Alveus Interneurons

Gavin Woodhall, Christine E. Gee, Richard Robitaille, and Jean-Claude Lacaille

Département de Physiologie and Centre de Recherche en Sciences Neurologiques, Université de Montréal, Montreal, Quebec H3C 3J7, Canada

Woodhall, Gavin, Christine E. Gee, Richard Robitaille, and Jean-Claude Lacaille. Membrane potential and intracellular Ca2+ oscillations activated by mGluRs in hippocampal stratum oriens/alveus interneurons. J. Neurophysiol. 81: 371-382, 1999. Metabotropic glutamate receptors (mGluRs) are expressed heterogeneously in hippocampal interneurons, and their signal transduction cascades remain largely unclear. We characterized an oscillatory response activated by the mGluR agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in hippocampal interneurons of stratum oriens-alveus (OA) with simultaneous whole cell current-clamp recordings and intracellular Ca2+ imaging with confocal microscopy. 1S,3R-ACPD induced oscillatory membrane depolarizations and rises in intracellular Ca2+ that persisted in tetrodotoxin and were blocked by the antagonist of group I and II mGluRs (S)-alpha -methyl-4-carboxyphenylglycine. Membrane depolarizations and intracellular Ca2+ rises were blocked by extracellular Cd2+ and in Ca2+-free medium. mGluR responses therefore required Ca2+ influx via voltage-gated Ca2+ channels. 1S,3R-ACPD responses were also antagonized by depleting intracellular stores with thapsigargin and ryanodine, indicating that Ca2+ release from intracellular stores was also necessary. These data suggest that oscillatory responses generated by group I/II mGluRs involve a coupling of Ca2+ entry through voltage-gated Ca2+ channels and Ca2+ release from internal stores. In contrast, 1S,3R-ACPD evoked only smaller depolarizations and intracellular Ca2+ rises, with no oscillations, in other hippocampal interneurons located in or near stratum lacunosum-moleculare. Thus mGluR-mediated oscillatory responses are specifically expressed in certain interneuron subtypes. This heterogeneous expression of glutamate and Ca2+ signaling pathways in specific interneurons may be relevant to their selective vulnerability to excitotoxicity.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
R. Levi and A. I. Selverston
Mechanisms Underlying Type I mGluR-Induced Activation of Lobster Gastric Mill Neurons
J Neurophysiol, December 1, 2006; 96(6): 3378 - 3388.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Topolnik, M. Azzi, F. Morin, A. Kougioumoutzakis, and J.-C. Lacaille
mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones
J. Physiol., August 15, 2006; 575(1): 115 - 131.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Serrano, N. Haddjeri, J.-C. Lacaille, and R. Robitaille
GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression.
J. Neurosci., May 17, 2006; 26(20): 5370 - 5382.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
R. Zur Nieden and J. W. Deitmer
The Role of Metabotropic Glutamate Receptors for the Generation of Calcium Oscillations in Rat Hippocampal Astrocytes In Situ
Cereb Cortex, May 1, 2006; 16(5): 676 - 687.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Wyart, S. Cocco, L. Bourdieu, J.-F. Leger, C. Herr, and D. Chatenay
Dynamics of Excitatory Synaptic Components in Sustained Firing at Low Rates
J Neurophysiol, June 1, 2005; 93(6): 3370 - 3380.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Topolnik, P. Congar, and J.-C. Lacaille
Differential Regulation of Metabotropic Glutamate Receptor- and AMPA Receptor-Mediated Dendritic Ca2+ Signals by Presynaptic and Postsynaptic Activity in Hippocampal Interneurons
J. Neurosci., January 26, 2005; 25(4): 990 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. Maccaferri
Stratum oriens horizontal interneurone diversity and hippocampal network dynamics
J. Physiol., January 1, 2005; 562(1): 73 - 80.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Kawamura, C. Gachet, K. Inoue, and F. Kato
Direct Excitation of Inhibitory Interneurons by Extracellular ATP Mediated by P2Y1 Receptors in the Hippocampal Slice
J. Neurosci., December 1, 2004; 24(48): 10835 - 10845.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. Lapointe, F. Morin, S. Ratte, A. Croce, F. Conquet, and J.-C. Lacaille
Synapse-specific mGluR1-dependent long-term potentiation in interneurones regulates mouse hippocampal inhibition
J. Physiol., February 15, 2004; 555(1): 125 - 135.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. Jin and R. D. Hawkins
Presynaptic and Postsynaptic Mechanisms of a Novel Form of Homosynaptic Potentiation at Aplysia Sensory-Motor Neuron Synapses
J. Neurosci., August 13, 2003; 23(19): 7288 - 7297.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Liu, L. Geng, R. Li, X. He, J. Q. Zheng, and Z. Xie
Frequency Modulation of Synchronized Ca2+ Spikes in Cultured Hippocampal Networks through G-Protein-Coupled Receptors
J. Neurosci., May 15, 2003; 23(10): 4156 - 4163.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Perez, F. Morin, and J.-C. Lacaille
A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons
PNAS, July 5, 2001; (2001) 161493498.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. L. Schomberg, G. Su, R. A. Haworth, and D. Sun
Stimulation of Na-K-2Cl Cotransporter in Neurons by Activation of Non-NMDA Ionotropic Receptor and Group-I mGluRs
J Neurophysiol, June 1, 2001; 85(6): 2563 - 2575.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. E. Gee, G. Woodhall, and J.-C. Lacaille
Synaptically Activated Calcium Responses in Dendrites of Hippocampal Oriens-Alveus Interneurons
J Neurophysiol, April 1, 2001; 85(4): 1603 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. G. Rae, D. J. Martin, G. L. Collingridge, and A. J. Irving
Role of Ca2+ Stores in Metabotropic L-Glutamate Receptor-Mediated Supralinear Ca2+ Signaling in Rat Hippocampal Neurons
J. Neurosci., December 1, 2000; 20(23): 8628 - 8636.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. A. van Hooft, R. Giuffrida, M. Blatow, and H. Monyer
Differential Expression of Group I Metabotropic Glutamate Receptors in Functionally Distinct Hippocampal Interneurons
J. Neurosci., May 15, 2000; 20(10): 3544 - 3551.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. C. Flint, R. S. Dammerman, and A. R. Kriegstein
Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations
PNAS, October 12, 1999; 96(21): 12144 - 12149.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Perez, F. Morin, and J.-C. Lacaille
A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons
PNAS, July 31, 2001; 98(16): 9401 - 9406.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online