JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 81: 447-454, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tredway, T. L.
Right arrow Articles by Chiappinelli, V. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tredway, T. L.
Right arrow Articles by Chiappinelli, V. A.

The Journal of Neurophysiology Vol. 81 No. 2 February 1999, pp. 447-454
Copyright ©1999 by the American Physiological Society

N-Type Voltage-Dependent Calcium Channels Mediate the Nicotinic Enhancement of GABA Release in Chick Brain

Trevor L. Tredway, Jian-Zhong Guo, and Vincent A. Chiappinelli

Department of Pharmacology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037

N-type voltage-dependent calcium channels mediate the nicotinic enhancement of GABA release in chick brain. The role of voltage-dependent calcium channels (VDCCs) in the nicotinic acetylcholine receptor (nAChR)-mediated enhancement of spontaneous GABAergic inhibitory postsynaptic currents (IPSCs) was investigated in chick brain slices. Whole cell recordings of neurons in the lateral spiriform (SpL) and ventral lateral geniculate (LGNv) nuclei showed that cadmium chloride (CdCl2) blocked the carbachol-induced increase of spontaneous GABAergic IPSCs, indicating that VDCCs might be involved. To conclusively show a role for VDCCs, the presynaptic effect of carbachol on SpL and LGNv neurons was examined in the presence of selective blockers of VDCC subtypes. omega -Conotoxin GVIA, a selective antagonist of N-type channels, significantly reduced the nAChR-mediated enhancement of gamma -aminobutyric acid (GABA) release in the SpL by 78% compared with control responses. Nifedipine, an L-type channel blocker, and omega -Agatoxin-TK, a P/Q-type channel blocker, did not inhibit the enhancement of GABAergic IPSCs. In the LGNv, omega -Conotoxin GVIA also significantly reduced the nAChR-mediated enhancement of GABA release by 71% from control values. Although omega -Agatoxin-TK did not block the nicotinic enhancement, L-type channel blockers showed complex effects on the nAChR-mediated enhancement. These results indicate that the nAChR-mediated enhancement of spontaneous GABAergic IPSCs requires activation of N-type channels in both the SpL and LGNv.

0022-3077/99 $5.00 Copyright © 1999 The American Physiological Society



This article has been cited by other articles:


Home page
 J. Neurosci.Home page
P. M. Newton, L. Zeng, V. Wang, J. Connolly, M. J. Wallace, C. Kim, H.-S. Shin, F. Belardetti, T. P. Snutch, and R. O. Messing
A Blocker of N- and T-type Voltage-Gated Calcium Channels Attenuates Ethanol-Induced Intoxication, Place Preference, Self-Administration, and Reinstatement
J. Neurosci., November 5, 2008; 28(45): 11712 - 11719.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
X. Guo and R. A. J. Lester
Regulation of Nicotinic Acetylcholine Receptor Desensitization by Ca2+
J Neurophysiol, January 1, 2007; 97(1): 93 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
X. Hou, L. J. Roberts II, D. F. Taber, J. D. Morrow, K. Kanai, F. Gobeil Jr., M. H. Beauchamp, S. G. Bernier, G. Lepage, D. R. Varma, et al.
2,3-Dinor-5,6-dihydro-15-F2t-isoprostane: a bioactive prostanoid metabolite
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R391 - R400.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Wang, M. Irnaten, and D. Mendelowitz
Agatoxin-IVA-Sensitive Calcium Channels Mediate the Presynaptic and Postsynaptic Nicotinic Activation of Cardiac Vagal Neurons
J Neurophysiol, January 1, 2001; 85(1): 164 - 168.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. A. Schneider, M. Perrone, and J. J. Galligan
Nicotinic Acetylcholine Receptors at Sites of Neurotransmitter Release to the Guinea Pig Intestinal Circular Muscle
J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 363 - 369.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online