| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 81 No. 2 February 1999, pp. 494-497
Copyright ©1999 by the American Physiological Society
1Institute of Neurophysiology, 2Institute of Cardiovascular Physiology, and 3Center for Biological and Medical Research, University of Düsseldorf, D-40001 Dusseldorf, Germany
Impairment of neocortical long-term potentiation in mice deficient of
endothelial nitric oxide synthase. The role of the possible retrograde messenger nitric oxide (NO) in the induction of long-term potentiation (LTP) was studied in supragranular layers of somatosensory cortical slices obtained from adult mice. High-frequency stimulation produced a slowly rising, long-lasting (50 min) and significant (P < 0.001) increase in the extracellular synaptic
response by 23%. The induction of LTP was independent from activation
of N-methyl-D-aspartate (NMDA) receptors, but
prevented by bath application of
NG-nitro-L-arginine methyl ester
(L-NAME), indicating that one or several of the different
NO synthases (NOS) produced NO within the postsynaptic neuron. No LTP
could be induced in knockout mice lacking the endothelial NOS (eNOS)
isoform. These data suggest that eNOS is involved in an NMDA
receptor-independent form of LTP in the rodent cerebral
cortex.
This article has been cited by other articles:
|
|
 |
|
  N. R. Hardingham, G. E. Hardingham, K. D. Fox, and J. J. B. Jack Presynaptic Efficacy Directs Normalization of Synaptic Strength in Layer 2/3 Rat Neocortex After Paired Activity J Neurophysiol, April 1, 2007; 97(4): 2965 - 2975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Haghikia, E. Mergia, A. Friebe, U. T. Eysel, D. Koesling, and T. Mittmann Long-Term Potentiation in the Visual Cortex Requires Both Nitric Oxide Receptor Guanylyl Cyclases J. Neurosci., January 24, 2007; 27(4): 818 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Hopper and J. Garthwaite Tonic and phasic nitric oxide signals in hippocampal long-term potentiation. J. Neurosci., November 8, 2006; 26(45): 11513 - 11521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Garthwaite, K. Bartus, D. Malcolm, D. Goodwin, M. Kollb-Sielecka, C. Dooldeniya, and J. Garthwaite Signaling from blood vessels to CNS axons through nitric oxide. J. Neurosci., July 19, 2006; 26(29): 7730 - 7740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hardingham and K. Fox The role of nitric oxide and GluR1 in presynaptic and postsynaptic components of neocortical potentiation. J. Neurosci., July 12, 2006; 26(28): 7395 - 7404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. LYNCH Long-Term Potentiation and Memory Physiol Rev, January 1, 2004; 84(1): 87 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Eder, W. Zieglgansberger, and H.-U. Dodt Neocortical Long-Term Potentiation and Long-Term Depression: Site of Expression Investigated by Infrared-Guided Laser Stimulation J. Neurosci., September 1, 2002; 22(17): 7558 - 7568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gelperin, J. P. Y. Kao, and I. R. C. Cooke Gaseous Oxides and Olfactory Computation Integr. Comp. Biol., April 1, 2001; 41(2): 332 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Frisch, E. Dere, M. A. D. S. Silva, A. Godecke, J. Schrader, and J. P. Huston Superior Water Maze Performance and Increase in Fear-Related Behavior in the Endothelial Nitric Oxide Synthase-Deficient Mouse Together with Monoamine Changes in Cerebellum and Ventral Striatum J. Neurosci., September 1, 2000; 20(17): 6694 - 6700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Rickard, M. E. Gibbs, and K. T. Ng Inhibition of the Endothelial Isoform of Nitric Oxide Synthase Impairs Long-Term Memory Formation in the Chick Learn. Mem., September 1, 1999; 6(5): 458 - 466. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
