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J Neurophysiol 81: 702-711, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 81 No. 2 February 1999, pp. 702-711
Copyright ©1999 by the American Physiological Society

An Intrinsic Oscillation in Interneurons of the Rat Lateral Geniculate Nucleus

J. Julius Zhu,1 William W. Lytton,2 Jin-Tang Xue,1 and Daniel J. Uhlrich1

 1Department of Anatomy and  2Department of Neurology, Neuroscience Training Program, Wm. S. Middleton VA Hospital, University of Wisconsin, Madison, Wisconsin 53706

Intrinsic oscillation in interneurons of the rat lateral geniculate nucleus. By using the whole cell patch recording technique in vitro, we examined the voltage-dependent firing patterns of 69 interneurons in the rat dorsal lateral geniculate nucleus (LGN). When held at a hyperpolarized membrane potential, all interneurons responded with a burst of action potentials. In 48 interneurons, larger current pulses produced a bursting oscillation. When relatively depolarized, some interneurons produced a tonic train of action potentials in response to a depolarizing current pulse. However, most interneurons produced only oscillations, regardless of polarization level. The oscillation was insensitive to the bath application of a combination of blockers to excitatory and inhibitory synaptic transmission, including 30 µM 6,7-dinitroquinoxaline-2,3-dione, 100 µM (±)-2-amino-5-phosphonopentanoic acid, 20 µM bicuculline, and 2 mM saclofen, suggesting an intrinsic event. The frequency of the oscillation in interneurons was dependent on the intensity of the injection current. Increasing current intensity increased the oscillation frequency. The maximal frequency of the oscillation was 5-15 Hz for most cells, with some ambiguity caused by the difficulty of precisely defining a transition from oscillatory to regular firing behavior. In contrast, the interneuron oscillation was little affected by preceding depolarizing and hyperpolarizing pulses. In addition to being elicited by depolarizing current injections, the oscillation could also be initiated by electrical stimulation of the optic tract when the interneurons were held at a depolarized membrane potential. This suggests that interneurons may be recruited into thalamic oscillations by synaptic inputs. These results indicate that interneurons may play a larger role in thalamic oscillations than was previously thought.

0022-3077/99 $5.00 Copyright © 1999 The American Physiological Society



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