JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 81: 702-711, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (28)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhu, J. J.
Right arrow Articles by Uhlrich, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhu, J. J.
Right arrow Articles by Uhlrich, D. J.

The Journal of Neurophysiology Vol. 81 No. 2 February 1999, pp. 702-711
Copyright ©1999 by the American Physiological Society

An Intrinsic Oscillation in Interneurons of the Rat Lateral Geniculate Nucleus

J. Julius Zhu,1 William W. Lytton,2 Jin-Tang Xue,1 and Daniel J. Uhlrich1

 1Department of Anatomy and  2Department of Neurology, Neuroscience Training Program, Wm. S. Middleton VA Hospital, University of Wisconsin, Madison, Wisconsin 53706

Intrinsic oscillation in interneurons of the rat lateral geniculate nucleus. By using the whole cell patch recording technique in vitro, we examined the voltage-dependent firing patterns of 69 interneurons in the rat dorsal lateral geniculate nucleus (LGN). When held at a hyperpolarized membrane potential, all interneurons responded with a burst of action potentials. In 48 interneurons, larger current pulses produced a bursting oscillation. When relatively depolarized, some interneurons produced a tonic train of action potentials in response to a depolarizing current pulse. However, most interneurons produced only oscillations, regardless of polarization level. The oscillation was insensitive to the bath application of a combination of blockers to excitatory and inhibitory synaptic transmission, including 30 µM 6,7-dinitroquinoxaline-2,3-dione, 100 µM (±)-2-amino-5-phosphonopentanoic acid, 20 µM bicuculline, and 2 mM saclofen, suggesting an intrinsic event. The frequency of the oscillation in interneurons was dependent on the intensity of the injection current. Increasing current intensity increased the oscillation frequency. The maximal frequency of the oscillation was 5-15 Hz for most cells, with some ambiguity caused by the difficulty of precisely defining a transition from oscillatory to regular firing behavior. In contrast, the interneuron oscillation was little affected by preceding depolarizing and hyperpolarizing pulses. In addition to being elicited by depolarizing current injections, the oscillation could also be initiated by electrical stimulation of the optic tract when the interneurons were held at a depolarized membrane potential. This suggests that interneurons may be recruited into thalamic oscillations by synaptic inputs. These results indicate that interneurons may play a larger role in thalamic oscillations than was previously thought.

0022-3077/99 $5.00 Copyright © 1999 The American Physiological Society



This article has been cited by other articles:


Home page
 J. Physiol.Home page
S. Augustinaite and P. Heggelund
Changes in firing pattern of lateral geniculate neurons caused by membrane potential dependent modulation of retinal input through NMDA receptors
J. Physiol., July 1, 2007; 582(1): 297 - 315.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. R. Llinas and M. Steriade
Bursting of Thalamic Neurons and States of Vigilance
J Neurophysiol, June 1, 2006; 95(6): 3297 - 3308.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
S. W. Hughes and V. Crunelli
Thalamic Mechanisms of EEG Alpha Rhythms and Their Pathological Implications
Neuroscientist, August 1, 2005; 11(4): 357 - 372.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
M.-C. Perreault, Y. Qin, P. Heggelund, and J J. Zhu
Postnatal development of GABAergic signalling in the rat lateral geniculate nucleus: presynaptic dendritic mechanisms
J. Physiol., January 1, 2003; 546(1): 137 - 148.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. S. Cymbalyuk, Q. Gaudry, M. A. Masino, and R. L. Calabrese
Bursting in Leech Heart Interneurons: Cell-Autonomous and Network-Based Mechanisms
J. Neurosci., December 15, 2002; 22(24): 10580 - 10592.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. E. Cain, B. S. Kapp, and C. B. Puryear
The Contribution of the Amygdala to Conditioned Thalamic Arousal
J. Neurosci., December 15, 2002; 22(24): 11026 - 11034.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
M. L. Hines and N. T. Carnevale
Neuron: A Tool for Neuroscientists
Neuroscientist, April 1, 2001; 7(2): 123 - 135.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
J. J. Zhu and P. Heggelund
Muscarinic Regulation of Dendritic and Axonal Outputs of Rat Thalamic Interneurons: A New Cellular Mechanism for Uncoupling Distal Dendrites
J. Neurosci., February 15, 2001; 21(4): 1148 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Bazhenov, I. Timofeev, M. Steriade, and T. Sejnowski
Spiking-Bursting Activity in the Thalamic Reticular Nucleus Initiates Sequences of Spindle Oscillations in Thalamic Networks
J Neurophysiol, August 1, 2000; 84(2): 1076 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. J. Zhu and F.-S. Lo
Three GABA Receptor-Mediated Postsynaptic Potentials in Interneurons in the Rat Lateral Geniculate Nucleus
J. Neurosci., July 15, 1999; 19(14): 5721 - 5730.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online