| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 81 No. 2 February 1999, pp. 712-721
Copyright ©1999 by the American Physiological Society
1Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305-5410; and 2Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523
In vivo intracellular analysis of granule cell axon reorganization in
epileptic rats. In vivo intracellular recording and labeling in
kainate-induced epileptic rats was used to address questions about
granule cell axon reorganization in temporal lobe epilepsy.
Individually labeled granule cells were reconstructed three
dimensionally and in their entirety. Compared with controls, granule
cells in epileptic rats had longer average axon length per cell; the
difference was significant in all strata of the dentate gyrus including
the hilus. In epileptic rats, at least one-third of the granule cells
extended an aberrant axon collateral into the molecular layer. Axon
projections into the molecular layer had an average summed length of 1 mm per cell and spanned 600 µm of the septotemporal axis of the
hippocampus
a distance within the normal span of granule cell axon
collaterals. These findings in vivo confirm results from previous in
vitro studies. Surprisingly, 12% of the granule cells in epileptic
rats, and none in controls, extended a basal dendrite into the hilus,
providing another route for recurrent excitation. Consistent with
recurrent excitation, many granule cells (56%) in epileptic rats
displayed a long-latency depolarization superimposed on a normal
inhibitory postsynaptic potential. These findings demonstrate changes,
occurring at the single-cell level after an epileptogenic hippocampal
injury, that could result in novel, local, recurrent circuits.
This article has been cited by other articles:
|
|
 |
|
  R. J. Morgan and I. Soltesz From the Cover: Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures PNAS, April 22, 2008; 105(16): 6179 - 6184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Epsztein, Y. Ben-Ari, A. Represa, and V. Crepel Late-Onset Epileptogenesis and Seizure Genesis: Lessons From Models of Cerebral Ischemia Neuroscientist, February 1, 2008; 14(1): 78 - 90. [Abstract] [PDF]
|
|
|
|
 |
|
 P. A. Williams, P. Larimer, Y. Gao, and B. W. Strowbridge Semilunar Granule Cells: Glutamatergic Neurons in the Rat Dentate Gyrus with Axon Collaterals in the Inner Molecular Layer J. Neurosci., December 12, 2007; 27(50): 13756 - 13761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Walter, B. L. Murphy, R. Y. K. Pun, A. L. Spieles-Engemann, and S. C. Danzer Pilocarpine-Induced Seizures Cause Selective Time-Dependent Changes to Adult-Generated Hippocampal Dentate Granule Cells J. Neurosci., July 11, 2007; 27(28): 7541 - 7552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jessberger, K. Nakashima, G. D. Clemenson Jr, E. Mejia, E. Mathews, K. Ure, S. Ogawa, C. M. Sinton, F. H. Gage, and J. Hsieh Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline J. Neurosci., May 30, 2007; 27(22): 5967 - 5975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Dyhrfjeld-Johnsen, V. Santhakumar, R. J. Morgan, R. Huerta, L. Tsimring, and I. Soltesz Topological Determinants of Epileptogenesis in Large-Scale Structural and Functional Models of the Dentate Gyrus Derived From Experimental Data J Neurophysiol, February 1, 2007; 97(2): 1566 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Epsztein, M. Milh, R. Id Bihi, I. Jorquera, Y. Ben-Ari, A. Represa, and V. Crepel Ongoing epileptiform activity in the post-ischemic hippocampus is associated with a permanent shift of the excitatory-inhibitory synaptic balance in CA3 pyramidal neurons. J. Neurosci., June 28, 2006; 26(26): 7082 - 7092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Epsztein, A. Represa, I. Jorquera, Y. Ben-Ari, and V. Crepel Recurrent Mossy Fibers Establish Aberrant Kainate Receptor-Operated Synapses on Granule Cells from Epileptic Rats J. Neurosci., September 7, 2005; 25(36): 8229 - 8239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Staley, J. L. Hellier, and F. E. Dudek Do Interictal Spikes Drive Epileptogenesis? Neuroscientist, August 1, 2005; 11(4): 272 - 276. [Abstract] [PDF]
|
|
|
|
|
|
L.-R. Shao and F. E. Dudek Changes in mIPSCs and sIPSCs After Kainate Treatment: Evidence for Loss of Inhibitory Input to Dentate Granule Cells and Possible Compensatory Responses J Neurophysiol, August 1, 2005; 94(2): 952 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Santhakumar, I. Aradi, and I. Soltesz Role of Mossy Fiber Sprouting and Mossy Cell Loss in Hyperexcitability: A Network Model of the Dentate Gyrus Incorporating Cell Types and Axonal Topography J Neurophysiol, January 1, 2005; 93(1): 437 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. d. H. Ratzliff, A. L. Howard, V. Santhakumar, I. Osapay, and I. Soltesz Rapid Deletion of Mossy Cells Does Not Result in a Hyperexcitable Dentate Gyrus: Implications for Epileptogenesis J. Neurosci., March 3, 2004; 24(9): 2259 - 2269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Zappone and R. S. Sloviter Translamellar Disinhibition in the Rat Hippocampal Dentate Gyrus after Seizure-Induced Degeneration of Vulnerable Hilar Neurons J. Neurosci., January 28, 2004; 24(4): 853 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Scharfman, A. L. Sollas, R. E. Berger, and J. H. Goodman Electrophysiological Evidence of Monosynaptic Excitatory Transmission Between Granule Cells After Seizure-Induced Mossy Fiber Sprouting J Neurophysiol, October 1, 2003; 90(4): 2536 - 2547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kobayashi and P. S. Buckmaster Reduced Inhibition of Dentate Granule Cells in a Model of Temporal Lobe Epilepsy J. Neurosci., March 15, 2003; 23(6): 2440 - 2452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Danzer, K. R. C. Crooks, D. C. Lo, and J. O. McNamara Increased Expression of Brain-Derived Neurotrophic Factor Induces Formation of Basal Dendrites and Axonal Branching in Dentate Granule Cells in Hippocampal Explant Cultures J. Neurosci., November 15, 2002; 22(22): 9754 - 9763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Williams, J.-P. Wuarin, P. Dou, D. J. Ferraro, and F. E. Dudek Reassessment of the Effects of Cycloheximide on Mossy Fiber Sprouting and Epileptogenesis in the Pilocarpine Model of Temporal Lobe Epilepsy J Neurophysiol, October 1, 2002; 88(4): 2075 - 2087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Jones and D. S. Barth Effects of Bicuculline Methiodide on Fast (>200 Hz) Electrical Oscillations in Rat Somatosensory Cortex J Neurophysiol, August 1, 2002; 88(2): 1016 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Buckmaster, G. F. Zhang, and R. Yamawaki Axon Sprouting in a Model of Temporal Lobe Epilepsy Creates a Predominantly Excitatory Feedback Circuit J. Neurosci., August 1, 2002; 22(15): 6650 - 6658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Parent, V. V. Valentin, and D. H. Lowenstein Prolonged Seizures Increase Proliferating Neuroblasts in the Adult Rat Subventricular Zone-Olfactory Bulb Pathway J. Neurosci., April 15, 2002; 22(8): 3174 - 3188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Wuarin and F. E. Dudek Excitatory Synaptic Input to Granule Cells Increases With Time After Kainate Treatment J Neurophysiol, March 1, 2001; 85(3): 1067 - 1077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Smith and F. E. Dudek Short- and Long-Term Changes in CA1 Network Excitability After Kainate Treatment in Rats J Neurophysiol, January 1, 2001; 85(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Scharfman, J. H. Goodman, and A. L. Sollas Granule-Like Neurons at the Hilar/CA3 Border after Status Epilepticus and Their Synchrony with Area CA3 Pyramidal Cells: Functional Implications of Seizure-Induced Neurogenesis J. Neurosci., August 15, 2000; 20(16): 6144 - 6158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Buckmaster, A. L. Jongen-Relo, S. B. Davari, and E. H. Wong Testing the Disinhibition Hypothesis of Epileptogenesis In Vivo and during Spontaneous Seizures J. Neurosci., August 15, 2000; 20(16): 6232 - 6240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lynch and T. Sutula Recurrent Excitatory Connectivity in the Dentate Gyrus of Kindled and Kainic Acid-Treated Rats J Neurophysiol, February 1, 2000; 83(2): 693 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Molnar and J. V. Nadler Mossy Fiber-Granule Cell Synapses in the Normal and Epileptic Rat Dentate Gyrus Studied With Minimal Laser Photostimulation J Neurophysiol, October 1, 1999; 82(4): 1883 - 1894. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
