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The Journal of Neurophysiology Vol. 81 No. 2 February 1999, pp. 758-770
Copyright ©1999 by the American Physiological Society
Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
Contribution of sensory feedback to the generation of extensor activity
during walking in the decerebrate cat. In this investigation we
have estimated the afferent contribution to the generation of activity
in the knee and ankle extensor muscles during walking in decerebrate
cats by loading and unloading extensor muscles, and by unilateral
deafferentation of a hind leg. The total contribution of afferent
feedback to extensor burst generation was estimated by allowing one
hind leg to step into a hole in the treadmill belt on which the animal
was walking. In the absence of ground support the level of activity in
knee and ankle extensor muscles was reduced to ~70% of normal.
Activity in the ankle extensors could be restored during the
"foot-in-hole" trials by selectively resisting extension at the
ankle. Thus feedback from proprioceptors in the ankle extensor muscles
probably makes a large contribution to burst generation in these
muscles during weight-bearing steps. Similarly, feedback from
proprioceptors in knee extensor appears to contribute substantially to
the activation of knee extensor muscles because unloading and loading
these muscles, by lifting and dropping the hindquarters, strongly
reduced and increased, respectively, the level of activity in the knee
extensors. This conclusion was supported by the finding that partial
deafferentation of one hind leg by transection of the
L4-L6 dorsal roots reduced the level of
activity in the knee extensors by ~50%, but did not noticeably
influence the activity in ankle extensor muscles. However, extending
the deafferentation to include the L7-S2
dorsal roots decreased the ankle extensor activity. We conclude that
afferent feedback contributes to more than one-half of the input to
knee and ankle extensor motoneurons during the stance phase of walking in decerebrate cats. The continuous contribution of afferent feedback to the generation of extensor activity could function to automatically adjust the intensity of activity to meet external demands.
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