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The Journal of Neurophysiology Vol. 81 No. 2 February 1999, pp. 908-920
Copyright ©1999 by the American Physiological Society
Department of Neurobiology, Stanford University, Stanford, California 94305
Correlated firing in rabbit retinal ganglion cells. A ganglion
cell's receptive field is defined as that region on the retinal surface in which a light stimulus will produce a response. While neighboring ganglion cells may respond to the same stimulus in a region
where their receptive fields overlap, it generally has been assumed
that each cell makes an independent decision about whether to fire.
Recent recordings from cat and salamander retina using multiple
electrodes have challenged this view of independent firing by showing
that neighboring ganglion cells have an increased tendency to fire
together within ±5 ms. However, there is still uncertainty about which
types of ganglion cells fire together, the mechanisms that produce
coordinated spikes, and the overall function of coordinated firing. To
address these issues, the responses of up to 80 rabbit retinal ganglion
cells were recorded simultaneously using a multielectrode array. Of the
11 classes of rabbit ganglion cells previously identified, coordinated
firing was observed in five. Plots of the spike train cross-correlation
function suggested that coordinated firing occurred through two
mechanisms. In the first mechanism, a spike in an interneuron diverged
to produce simultaneous spikes in two ganglion cells. This mechanism
predominated in four of the five classes including the ON
brisk transient cells. In the second mechanism, ganglion cells appeared
to activate each other reciprocally. This was the predominant pattern
of correlated firing in OFF brisk transient cells. By
comparing the receptive field profiles of ON and
OFF brisk transient cells, a peripheral extension of the
OFF brisk transient cell receptive field was identified
that might be produced by lateral spike spread. Thus an individual
OFF brisk transient cell can respond both to a light stimulus directed at the center of its receptive field and to stimuli
that activate neighboring OFF brisk transient cells through their receptive field centers.
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