JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 81: 1296-1307, 1999;
0022-3077/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (51)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chapman, C. A.
Right arrow Articles by Lacaille, J.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chapman, C. A.
Right arrow Articles by Lacaille, J.-C.

The Journal of Neurophysiology Vol. 81 No. 3 March 1999, pp. 1296-1307
Copyright ©1999 by the American Physiological Society

Intrinsic Theta-Frequency Membrane Potential Oscillations in Hippocampal CA1 Interneurons of Stratum Lacunosum-Moleculare

C. Andrew Chapman and Jean-Claude Lacaille

Centre de Recherche en Sciences Neurologiques et Département de Physiologie, Université de Montréal, Montreal, Quebec H3C 3J7, Canada

Chapman, C. Andrew and Jean-Claude Lacaille. Intrinsic theta-frequency membrane potential oscillations in hippocampal CA1 interneurons of stratum lacunosum-moleculare. The ionic conductances underlying membrane potential oscillations of hippocampal CA1 interneurons located near the border between stratum lacunosum-moleculare and stratum radiatum (LM) were investigated using whole cell current-clamp recordings in rat hippocampal slices. At 22°C, when LM cells were depolarized near spike threshold by current injection, 91% of cells displayed 2-5 Hz oscillations in membrane potential, which caused rhythmic firing. At 32°C, mean oscillation frequency increased to 7.1 Hz. Oscillations were voltage dependent and were eliminated by hyperpolarizing cells 6-10 mV below spike threshold. Blockade of ionotropic glutamate and GABA synaptic transmission did not affect oscillations, indicating that they were not synaptically driven. Oscillations were eliminated by tetrodotoxin, suggesting that Na+ currents generate the depolarizing phase of oscillations. Oscillations were not affected by blocking Ca2+ currents with Cd2+ or Ca2+-free ACSF or by blocking the hyperpolarization-activated current (Ih) with Cs+. Both Ba2+ and a low concentration of 4-aminopyridine (4-AP) reduced oscillations but TEA did not. Theta-frequency oscillations were much less common in interneurons located in stratum oriens. Intrinsic membrane potential oscillations in LM cells of the CA1 region thus involve an interplay between inward Na+ currents and outward K+ currents sensitive to Ba2+ and 4-AP. These oscillations may participate in rhythmic inhibition and synchronization of pyramidal neurons during theta activity in vivo.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
S. D. Glasgow and C. A. Chapman
Conductances Mediating Intrinsic Theta-Frequency Membrane Potential Oscillations in Layer II Parasubicular Neurons
J Neurophysiol, November 1, 2008; 100(5): 2746 - 2756.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. D. Glasgow and C. A. Chapman
Local Generation of Theta-Frequency EEG Activity in the Parasubiculum
J Neurophysiol, June 1, 2007; 97(6): 3868 - 3879.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. L. Bourdeau, F. Morin, C. E. Laurent, M. Azzi, and J.-C. Lacaille
Kv4.3-Mediated A-Type K+ Currents Underlie Rhythmic Activity in Hippocampal Interneurons
J. Neurosci., February 21, 2007; 27(8): 1942 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. Orban, T. Kiss, and P. Erdi
Intrinsic and Synaptic Mechanisms Determining the Timing of Neuron Population Activity During Hippocampal Theta Oscillation
J Neurophysiol, December 1, 2006; 96(6): 2889 - 2904.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. G. Rotstein, D. D. Pervouchine, C. D. Acker, M. J. Gillies, J. A. White, E. H. Buhl, M. A. Whittington, and N. Kopell
Slow and Fast Inhibition and an H-Current Interact to Create a Theta Rhythm in a Model of CA1 Interneuron Network
J Neurophysiol, August 1, 2005; 94(2): 1509 - 1518.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. J. Price, B. Cauli, E. R. Kovacs, A. Kulik, B. Lambolez, R. Shigemoto, and M. Capogna
Neurogliaform Neurons Form a Novel Inhibitory Network in the Hippocampal CA1 Area
J. Neurosci., July 20, 2005; 25(29): 6775 - 6786.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. L Garner, M. A Whittington, and Z. Henderson
Induction by kainate of theta frequency rhythmic activity in the rat medial septum-diagonal band complex in vitro
J. Physiol., April 1, 2005; 564(1): 83 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. A Jacobson, K. Diba, A. Yaron-Jakoubovitch, Y. Oz, C. Koch, I. Segev, and Y. Yarom
Subthreshold voltage noise of rat neocortical pyramidal neurones
J. Physiol., April 1, 2005; 564(1): 145 - 160.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. A. Otmakhova and J. E. Lisman
Contribution of Ih and GABAB to Synaptically Induced Afterhyperpolarizations in CA1: A Brake on the NMDA Response
J Neurophysiol, October 1, 2004; 92(4): 2027 - 2039.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y. Fujiwara-Tsukamoto, Y. Isomura, K. Kaneda, and M. Takada
Synaptic interactions between pyramidal cells and interneurone subtypes during seizure-like activity in the rat hippocampus
J. Physiol., June 15, 2004; 557(3): 961 - 979.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Patenaude, C A. Chapman, S. Bertrand, P. Congar, and J.-C. Lacaille
GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission
J. Physiol., November 15, 2003; 553(1): 155 - 167.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. H. Bland, J. Konopacki, and R. H. Dyck
Relationship Between Membrane Potential Oscillations and Rhythmic Discharges in Identified Hippocampal Theta-Related Cells
J Neurophysiol, December 1, 2002; 88(6): 3046 - 3066.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. C. Magee
Dendritic Mechanisms of Phase Precession in Hippocampal CA1 Pyramidal Neurons
J Neurophysiol, July 1, 2001; 86(1): 528 - 532.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Savic, P. Pedarzani, and M. Sciancalepore
Medium Afterhyperpolarization and Firing Pattern Modulation in Interneurons of Stratum Radiatum in the CA3 Hippocampal Region
J Neurophysiol, May 1, 2001; 85(5): 1986 - 1997.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. G Pike, R. S Goddard, J. M Suckling, P. Ganter, N. Kasthuri, and O. Paulsen
Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents
J. Physiol., November 15, 2000; 529(1): 205 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. White, M. I. Banks, R. A. Pearce, and N. J. Kopell
Networks of interneurons with fast and slow gamma -aminobutyric acid type A (GABAA) kinetics provide substrate for mixed gamma-theta rhythm
PNAS, June 23, 2000; (2000) 100124097.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
D. Ji and J. A. Dani
Inhibition and Disinhibition of Pyramidal Neurons by Activation of Nicotinic Receptors on Hippocampal Interneurons
J Neurophysiol, May 1, 2000; 83(5): 2682 - 2690.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. A. Chapman and J.-C. Lacaille
Cholinergic Induction of Theta-Frequency Oscillations in Hippocampal Inhibitory Interneurons and Pacing of Pyramidal Cell Firing
J. Neurosci., October 1, 1999; 19(19): 8637 - 8645.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. White, M. I. Banks, R. A. Pearce, and N. J. Kopell
Networks of interneurons with fast and slow gamma -aminobutyric acid type A (GABAA) kinetics provide substrate for mixed gamma-theta rhythm
PNAS, July 5, 2000; 97(14): 8128 - 8133.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online