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J Neurophysiol 81: 1365-1378, 1999;
0022-3077/99 $5.00
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The Journal of Neurophysiology Vol. 81 No. 3 March 1999, pp. 1365-1378
Copyright ©1999 by the American Physiological Society

Electrophysiological Properties of Rat Phrenic Motoneurons During Perinatal Development

Miguel Martin-Caraballo and John J. Greer

Department of Physiology, Division of Neuroscience, University of Alberta, Edmonton, Alberta T6G 2S2 Canada

Martin-Caraballo, Miguel and John J. Greer. Electrophysiological properties of rat phrenic motoneurons during perinatal development. Past studies determined that there is a critical period at approximately embryonic day (E)17 during which phrenic motoneurons (PMNs) undergo a number of pivotal developmental events, including the inception of functional recruitment via synaptic drive from medullary respiratory centers, contact with spinal afferent terminals, the completion of diaphragm innervation, and a major transformation of PMN morphology. The objective of this study was to test the hypothesis that there would be a marked maturation of motoneuron electrophysiological properties occurring in conjunction with these developmental processes. PMN properties were measured via whole cell patch recordings with a cervical slice-phrenic nerve preparation isolated from perinatal rats. From E16 to postnatal day 1, there was a considerable transformation in a number of motoneuron properties, including 1) 10-mV increase in the hyperpolarization of the resting membrane potential, 2) threefold reduction in the input resistance, 3) 12-mV increase in amplitude and 50% decrease duration of action potential, 4) major changes in the shapes of potassium- and calcium-mediated afterpotentials, 5) decline in the prominence of calcium-dependent rebound depolarizations, and 6) increases in rheobase current and steady-state firing rates. Electrical coupling among PMNs was detected in 15-25% of recordings at all ages studied. Collectively, these data and those from parallel studies of PMN-diaphragm ontogeny describe how a multitude of regulatory mechanisms operate in concert during the embryonic development of a single mammalian neuromuscular system.




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